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Adipocyte Size is Associated with NAFLD Independent of Obesity, Fat Distribution, and PNPLA3 Genotype

Petaja, Elina M.; Sevastianova, Ksenia; Hakkarainen, Antti; Orho-Melander, Marju LU ; Lundbom, Nina and Yki-Jarvinen, Hannele (2013) In Obesity 21(6). p.1174-1179
Abstract
Objective: Adipocyte hypertrophy has been suggested to be causally linked with inflammation and systemic insulin resistance. The aim of the study was to determine whether increased adipocyte size is associated with increased liver fat content due to nonalcoholic fatty liver disease (NAFLD) in humans independent of obesity, fat distribution and genetic variation in the patatin-like phospholipase domain-containing 3 gene (PNPLA3; adiponutrin) at rs738409. Design and Methods: One hundred nineteen non-diabetic subjects in a cross-sectional study with a median age of 39 (26-53) years, mean +/- SD BMI of 30.0 +/- 5.7 kg m(-2) were studied. Abdominal subcutaneous (SC) adipocyte size, liver fat [proton magnetic resonance spectroscopy (H-1-MRS)],... (More)
Objective: Adipocyte hypertrophy has been suggested to be causally linked with inflammation and systemic insulin resistance. The aim of the study was to determine whether increased adipocyte size is associated with increased liver fat content due to nonalcoholic fatty liver disease (NAFLD) in humans independent of obesity, fat distribution and genetic variation in the patatin-like phospholipase domain-containing 3 gene (PNPLA3; adiponutrin) at rs738409. Design and Methods: One hundred nineteen non-diabetic subjects in a cross-sectional study with a median age of 39 (26-53) years, mean +/- SD BMI of 30.0 +/- 5.7 kg m(-2) were studied. Abdominal subcutaneous (SC) adipocyte size, liver fat [proton magnetic resonance spectroscopy (H-1-MRS)], intra-abdominal (IA), and abdominal SC adipose tissue volumes [magnetic resonance imaging (MRI)] and the PNPLA3 genotype at rs738409 were determined. Univariate and multiple linear regression analysis were used to identify independent predictors of liver fat content. Results: In multiple linear regression analysis, age, gender, BMI, the IA/SC ratio, and PNPLA3 genotype explained 42% of variation in liver fat content. Addition of adipocyte size (P < 0.0001) to the model increased the percent of explanation to 53%. Thus, 21% of known variation in liver fat could be explained by adipocyte size alone. Conclusions:: Increased adipocyte size highly significantly contributes to liver fat accumulation independent of other causes. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Obesity
volume
21
issue
6
pages
1174 - 1179
publisher
Nature Publishing Group
external identifiers
  • wos:000322487000017
  • scopus:84881351041
ISSN
1930-739X
DOI
10.1002/oby.20114
language
English
LU publication?
yes
id
07e6d6f1-bab6-4cf9-bcc3-c2e3ed42de0a (old id 4050211)
date added to LUP
2013-10-01 15:19:58
date last changed
2019-02-20 01:10:18
@article{07e6d6f1-bab6-4cf9-bcc3-c2e3ed42de0a,
  abstract     = {Objective: Adipocyte hypertrophy has been suggested to be causally linked with inflammation and systemic insulin resistance. The aim of the study was to determine whether increased adipocyte size is associated with increased liver fat content due to nonalcoholic fatty liver disease (NAFLD) in humans independent of obesity, fat distribution and genetic variation in the patatin-like phospholipase domain-containing 3 gene (PNPLA3; adiponutrin) at rs738409. Design and Methods: One hundred nineteen non-diabetic subjects in a cross-sectional study with a median age of 39 (26-53) years, mean +/- SD BMI of 30.0 +/- 5.7 kg m(-2) were studied. Abdominal subcutaneous (SC) adipocyte size, liver fat [proton magnetic resonance spectroscopy (H-1-MRS)], intra-abdominal (IA), and abdominal SC adipose tissue volumes [magnetic resonance imaging (MRI)] and the PNPLA3 genotype at rs738409 were determined. Univariate and multiple linear regression analysis were used to identify independent predictors of liver fat content. Results: In multiple linear regression analysis, age, gender, BMI, the IA/SC ratio, and PNPLA3 genotype explained 42% of variation in liver fat content. Addition of adipocyte size (P &lt; 0.0001) to the model increased the percent of explanation to 53%. Thus, 21% of known variation in liver fat could be explained by adipocyte size alone. Conclusions:: Increased adipocyte size highly significantly contributes to liver fat accumulation independent of other causes.},
  author       = {Petaja, Elina M. and Sevastianova, Ksenia and Hakkarainen, Antti and Orho-Melander, Marju and Lundbom, Nina and Yki-Jarvinen, Hannele},
  issn         = {1930-739X},
  language     = {eng},
  number       = {6},
  pages        = {1174--1179},
  publisher    = {Nature Publishing Group},
  series       = {Obesity},
  title        = {Adipocyte Size is Associated with NAFLD Independent of Obesity, Fat Distribution, and PNPLA3 Genotype},
  url          = {http://dx.doi.org/10.1002/oby.20114},
  volume       = {21},
  year         = {2013},
}