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Coffee is associated with lower breast tumor insulin-like growth factor receptor 1 levels in normal-weight patients and improved prognosis following tamoxifen or radiotherapy treatment

Björner, Sofie LU ; Rosendahl, Ann H. LU ; Tryggvadottir, Helga LU ; Simonsson, Maria LU ; Jirström, Karin LU ; Borgquist, Signe LU ; Rose, Carsten LU ; Ingvar, Christian LU and Jernström, Helena LU (2018) In Frontiers in Endocrinology 9(JUN).
Abstract

Coffee is associated with decreased breast cancer risk, but the impact of body mass index (BMI) in combination with coffee consumption on prognosis is unclear. The suppressive effect of coffee constituents on the insulin-like growth factor receptor 1 (IGF1R) levels in breast cancer cells may play a role. The aim was to investigate the prognostic impact of coffee consumption and possible associations with tumor-specific IGF1R protein expression and BMI in a population-based cohort in Sweden, comprising 1,014 primary breast cancer patients without pretreatment enrolled 2002-2012 and followed for up to 13 years. Patients with higher coffee consumption had lower tumor IGF1R levels (P = 0.025), but only among the normal-weight patients (P =... (More)

Coffee is associated with decreased breast cancer risk, but the impact of body mass index (BMI) in combination with coffee consumption on prognosis is unclear. The suppressive effect of coffee constituents on the insulin-like growth factor receptor 1 (IGF1R) levels in breast cancer cells may play a role. The aim was to investigate the prognostic impact of coffee consumption and possible associations with tumor-specific IGF1R protein expression and BMI in a population-based cohort in Sweden, comprising 1,014 primary breast cancer patients without pretreatment enrolled 2002-2012 and followed for up to 13 years. Patients with higher coffee consumption had lower tumor IGF1R levels (P = 0.025), but only among the normal-weight patients (P = 0.005). Coffee did not impact the recurrence-risk overall. However, tamoxifen-treated patients with ER+ tumors drinking ≥ 2 cups of coffee/day had lower recurrence-risk [adjusted HR (HRadj) 0.57, 95% CI, 0.34-0.97] compared with patients with lower intake, although only among normal-weight patients (HRadj 0.37, 95% CI: 0.17-0.78; Pinteraction = 0.039). Similarly, coffee consumption ≥ 2 cups/day was associated with significantly lower recurrence-risk among the 640 radiotherapy-treated patients irrespective of BMI (HRadj 0.59, 95% CI 0.36-0.98) and in the 296 normal-weight patients (HRadj 0.36, 95% CI 0.17-0.76) but not in the 329 overweight or obese patients (HRadj 0.88, 95% CI 0.42-1.82) although the interaction was not significant (Pinteraction = 0.093). In conclusion, coffee consumption was negatively associated with tumor-specific IGF1R levels only among normal-weight patients. Though, IGF1R did not explain the association between coffee intake and improved prognosis among normal-weight tamoxifen- or radiotherapy-treated patients. Studies of IGF1R-targeting therapies may benefit from taking BMI and coffee consumption into account.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Body mass index, Breast cancer, Coffee, Insulin-like growth factor receptor 1, Prognosis
in
Frontiers in Endocrinology
volume
9
issue
JUN
publisher
Frontiers
external identifiers
  • scopus:85048639920
ISSN
1664-2392
DOI
10.3389/fendo.2018.00306
language
English
LU publication?
yes
id
080d3ae7-bb12-47a3-a1c3-06838a8a3427
date added to LUP
2018-06-29 11:37:35
date last changed
2019-01-06 13:58:47
@article{080d3ae7-bb12-47a3-a1c3-06838a8a3427,
  abstract     = {<p>Coffee is associated with decreased breast cancer risk, but the impact of body mass index (BMI) in combination with coffee consumption on prognosis is unclear. The suppressive effect of coffee constituents on the insulin-like growth factor receptor 1 (IGF1R) levels in breast cancer cells may play a role. The aim was to investigate the prognostic impact of coffee consumption and possible associations with tumor-specific IGF1R protein expression and BMI in a population-based cohort in Sweden, comprising 1,014 primary breast cancer patients without pretreatment enrolled 2002-2012 and followed for up to 13 years. Patients with higher coffee consumption had lower tumor IGF1R levels (P = 0.025), but only among the normal-weight patients (P = 0.005). Coffee did not impact the recurrence-risk overall. However, tamoxifen-treated patients with ER<sup>+</sup> tumors drinking ≥ 2 cups of coffee/day had lower recurrence-risk [adjusted HR (HR<sub>adj</sub>) 0.57, 95% CI, 0.34-0.97] compared with patients with lower intake, although only among normal-weight patients (HR<sub>adj</sub> 0.37, 95% CI: 0.17-0.78; P<sub>interaction</sub> = 0.039). Similarly, coffee consumption ≥ 2 cups/day was associated with significantly lower recurrence-risk among the 640 radiotherapy-treated patients irrespective of BMI (HR<sub>adj</sub> 0.59, 95% CI 0.36-0.98) and in the 296 normal-weight patients (HR<sub>adj</sub> 0.36, 95% CI 0.17-0.76) but not in the 329 overweight or obese patients (HR<sub>adj</sub> 0.88, 95% CI 0.42-1.82) although the interaction was not significant (P<sub>interaction</sub> = 0.093). In conclusion, coffee consumption was negatively associated with tumor-specific IGF1R levels only among normal-weight patients. Though, IGF1R did not explain the association between coffee intake and improved prognosis among normal-weight tamoxifen- or radiotherapy-treated patients. Studies of IGF1R-targeting therapies may benefit from taking BMI and coffee consumption into account.</p>},
  articleno    = {306},
  author       = {Björner, Sofie and Rosendahl, Ann H. and Tryggvadottir, Helga and Simonsson, Maria and Jirström, Karin and Borgquist, Signe and Rose, Carsten and Ingvar, Christian and Jernström, Helena},
  issn         = {1664-2392},
  keyword      = {Body mass index,Breast cancer,Coffee,Insulin-like growth factor receptor 1,Prognosis},
  language     = {eng},
  month        = {06},
  number       = {JUN},
  publisher    = {Frontiers},
  series       = {Frontiers in Endocrinology},
  title        = {Coffee is associated with lower breast tumor insulin-like growth factor receptor 1 levels in normal-weight patients and improved prognosis following tamoxifen or radiotherapy treatment},
  url          = {http://dx.doi.org/10.3389/fendo.2018.00306},
  volume       = {9},
  year         = {2018},
}