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The Game of Tubulins

Alvarado Kristensson, Maria LU (2021) In Cells 10.
Abstract
Members of the tubulin superfamily are GTPases; the activities of GTPases are necessary for life. The members of the tubulin superfamily are the constituents of the microtubules and the γ-tubulin meshwork. Mutations in members of the tubulin superfamily are involved in developmental brain disorders, and tubulin activities are the target for various chemotherapies. The intricate functions (game) of tubulins depend on the activities of the GTP-binding domain of α-, β-, and γ-tubulin. This review compares the GTP-binding domains of γ-tubulin, α-tubulin, and β-tubulin and, based on their similarities, recapitulates the known functions and the impact of the γ-tubulin GTP-binding domain in the regulation of the γ-tubulin meshwork and cellular... (More)
Members of the tubulin superfamily are GTPases; the activities of GTPases are necessary for life. The members of the tubulin superfamily are the constituents of the microtubules and the γ-tubulin meshwork. Mutations in members of the tubulin superfamily are involved in developmental brain disorders, and tubulin activities are the target for various chemotherapies. The intricate functions (game) of tubulins depend on the activities of the GTP-binding domain of α-, β-, and γ-tubulin. This review compares the GTP-binding domains of γ-tubulin, α-tubulin, and β-tubulin and, based on their similarities, recapitulates the known functions and the impact of the γ-tubulin GTP-binding domain in the regulation of the γ-tubulin meshwork and cellular homeostasis. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cells
volume
10
article number
745
publisher
MDPI AG
external identifiers
  • scopus:85103862830
  • pmid:33800665
ISSN
2073-4409
DOI
10.3390/cells10040745
language
English
LU publication?
yes
id
081b1ee9-3ba5-4ec5-8c34-82cbee255782
date added to LUP
2021-03-28 16:01:49
date last changed
2022-05-12 19:07:01
@article{081b1ee9-3ba5-4ec5-8c34-82cbee255782,
  abstract     = {{Members of the tubulin superfamily are GTPases; the activities of GTPases are necessary for life. The members of the tubulin superfamily are the constituents of the microtubules and the γ-tubulin meshwork. Mutations in members of the tubulin superfamily are involved in developmental brain disorders, and tubulin activities are the target for various chemotherapies. The intricate functions (game) of tubulins depend on the activities of the GTP-binding domain of α-, β-, and γ-tubulin. This review compares the GTP-binding domains of γ-tubulin, α-tubulin, and β-tubulin and, based on their similarities, recapitulates the known functions and the impact of the γ-tubulin GTP-binding domain in the regulation of the γ-tubulin meshwork and cellular homeostasis.}},
  author       = {{Alvarado Kristensson, Maria}},
  issn         = {{2073-4409}},
  language     = {{eng}},
  publisher    = {{MDPI AG}},
  series       = {{Cells}},
  title        = {{The Game of Tubulins}},
  url          = {{http://dx.doi.org/10.3390/cells10040745}},
  doi          = {{10.3390/cells10040745}},
  volume       = {{10}},
  year         = {{2021}},
}