Plasma Heme Scavengers Alpha-1-Microglobulin and Hemopexin as Biomarkers in High-Risk Pregnancies
(2019) In Frontiers in Physiology 10.- Abstract
Women with established preeclampsia (PE) have increased plasma concentration of free fetal hemoglobin. We measured two hemoglobin scavenger system proteins, hemopexin (Hpx) and alpha-1-microglobulin (A1M) in maternal plasma using enzyme-linked immunosorbent assay during the late second trimester of pregnancy in women with high and low risk of developing PE. In total 142 women were included in nested case-control study: 42 women diagnosed with PE and 100 controls (49 randomly selected high-risk and 51 low-risk controls). The concentration of plasma A1M in high-risk controls was higher compared to low-risk controls. Women with severe PE had higher plasma A1M levels compared to women with non-severe PE. In conclusion, the concentration of... (More)
Women with established preeclampsia (PE) have increased plasma concentration of free fetal hemoglobin. We measured two hemoglobin scavenger system proteins, hemopexin (Hpx) and alpha-1-microglobulin (A1M) in maternal plasma using enzyme-linked immunosorbent assay during the late second trimester of pregnancy in women with high and low risk of developing PE. In total 142 women were included in nested case-control study: 42 women diagnosed with PE and 100 controls (49 randomly selected high-risk and 51 low-risk controls). The concentration of plasma A1M in high-risk controls was higher compared to low-risk controls. Women with severe PE had higher plasma A1M levels compared to women with non-severe PE. In conclusion, the concentration of plasma A1M is increased in the late second trimester in high-risk controls, suggesting activation of endogenous protective system against oxidative stress.
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- author
- Kalapotharakos, Grigorios
LU
; Murtoniemi, Katja
; Åkerström, Bo
LU
; Hämäläinen, Esa
; Kajantie, Eero
; Räikkönen, Katri
; Villa, Pia
; Laivuori, Hannele
and Hansson, Stefan R
LU
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Frontiers in Physiology
- volume
- 10
- article number
- 300
- publisher
- Frontiers Media S. A.
- external identifiers
-
- pmid:31019465
- scopus:85068258590
- ISSN
- 1664-042X
- DOI
- 10.3389/fphys.2019.00300
- language
- English
- LU publication?
- yes
- id
- 08264e45-57e6-420f-af88-596af84e5115
- date added to LUP
- 2019-05-22 09:37:58
- date last changed
- 2024-04-02 05:18:25
@article{08264e45-57e6-420f-af88-596af84e5115, abstract = {{<p>Women with established preeclampsia (PE) have increased plasma concentration of free fetal hemoglobin. We measured two hemoglobin scavenger system proteins, hemopexin (Hpx) and alpha-1-microglobulin (A1M) in maternal plasma using enzyme-linked immunosorbent assay during the late second trimester of pregnancy in women with high and low risk of developing PE. In total 142 women were included in nested case-control study: 42 women diagnosed with PE and 100 controls (49 randomly selected high-risk and 51 low-risk controls). The concentration of plasma A1M in high-risk controls was higher compared to low-risk controls. Women with severe PE had higher plasma A1M levels compared to women with non-severe PE. In conclusion, the concentration of plasma A1M is increased in the late second trimester in high-risk controls, suggesting activation of endogenous protective system against oxidative stress.</p>}}, author = {{Kalapotharakos, Grigorios and Murtoniemi, Katja and Åkerström, Bo and Hämäläinen, Esa and Kajantie, Eero and Räikkönen, Katri and Villa, Pia and Laivuori, Hannele and Hansson, Stefan R}}, issn = {{1664-042X}}, language = {{eng}}, publisher = {{Frontiers Media S. A.}}, series = {{Frontiers in Physiology}}, title = {{Plasma Heme Scavengers Alpha-1-Microglobulin and Hemopexin as Biomarkers in High-Risk Pregnancies}}, url = {{http://dx.doi.org/10.3389/fphys.2019.00300}}, doi = {{10.3389/fphys.2019.00300}}, volume = {{10}}, year = {{2019}}, }