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Plasma Heme Scavengers Alpha-1-Microglobulin and Hemopexin as Biomarkers in High-Risk Pregnancies

Kalapotharakos, Grigorios LU ; Murtoniemi, Katja ; Åkerström, Bo LU ; Hämäläinen, Esa ; Kajantie, Eero ; Räikkönen, Katri ; Villa, Pia ; Laivuori, Hannele and Hansson, Stefan R LU orcid (2019) In Frontiers in Physiology 10.
Abstract

Women with established preeclampsia (PE) have increased plasma concentration of free fetal hemoglobin. We measured two hemoglobin scavenger system proteins, hemopexin (Hpx) and alpha-1-microglobulin (A1M) in maternal plasma using enzyme-linked immunosorbent assay during the late second trimester of pregnancy in women with high and low risk of developing PE. In total 142 women were included in nested case-control study: 42 women diagnosed with PE and 100 controls (49 randomly selected high-risk and 51 low-risk controls). The concentration of plasma A1M in high-risk controls was higher compared to low-risk controls. Women with severe PE had higher plasma A1M levels compared to women with non-severe PE. In conclusion, the concentration of... (More)

Women with established preeclampsia (PE) have increased plasma concentration of free fetal hemoglobin. We measured two hemoglobin scavenger system proteins, hemopexin (Hpx) and alpha-1-microglobulin (A1M) in maternal plasma using enzyme-linked immunosorbent assay during the late second trimester of pregnancy in women with high and low risk of developing PE. In total 142 women were included in nested case-control study: 42 women diagnosed with PE and 100 controls (49 randomly selected high-risk and 51 low-risk controls). The concentration of plasma A1M in high-risk controls was higher compared to low-risk controls. Women with severe PE had higher plasma A1M levels compared to women with non-severe PE. In conclusion, the concentration of plasma A1M is increased in the late second trimester in high-risk controls, suggesting activation of endogenous protective system against oxidative stress.

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; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Frontiers in Physiology
volume
10
article number
300
publisher
Frontiers Media S. A.
external identifiers
  • pmid:31019465
  • scopus:85068258590
ISSN
1664-042X
DOI
10.3389/fphys.2019.00300
language
English
LU publication?
yes
id
08264e45-57e6-420f-af88-596af84e5115
date added to LUP
2019-05-22 09:37:58
date last changed
2024-06-25 14:19:55
@article{08264e45-57e6-420f-af88-596af84e5115,
  abstract     = {{<p>Women with established preeclampsia (PE) have increased plasma concentration of free fetal hemoglobin. We measured two hemoglobin scavenger system proteins, hemopexin (Hpx) and alpha-1-microglobulin (A1M) in maternal plasma using enzyme-linked immunosorbent assay during the late second trimester of pregnancy in women with high and low risk of developing PE. In total 142 women were included in nested case-control study: 42 women diagnosed with PE and 100 controls (49 randomly selected high-risk and 51 low-risk controls). The concentration of plasma A1M in high-risk controls was higher compared to low-risk controls. Women with severe PE had higher plasma A1M levels compared to women with non-severe PE. In conclusion, the concentration of plasma A1M is increased in the late second trimester in high-risk controls, suggesting activation of endogenous protective system against oxidative stress.</p>}},
  author       = {{Kalapotharakos, Grigorios and Murtoniemi, Katja and Åkerström, Bo and Hämäläinen, Esa and Kajantie, Eero and Räikkönen, Katri and Villa, Pia and Laivuori, Hannele and Hansson, Stefan R}},
  issn         = {{1664-042X}},
  language     = {{eng}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in Physiology}},
  title        = {{Plasma Heme Scavengers Alpha-1-Microglobulin and Hemopexin as Biomarkers in High-Risk Pregnancies}},
  url          = {{http://dx.doi.org/10.3389/fphys.2019.00300}},
  doi          = {{10.3389/fphys.2019.00300}},
  volume       = {{10}},
  year         = {{2019}},
}