Peptide nanotube formation: a crystal growth process
(2012) In Soft Matter 8(28). p.7463-7470- Abstract
- Above its critical aggregation concentration the tfa salt of the peptide A(6)K self-assembles into micron long, hollow nanotubes with uniform diameters of 52 nm and crystalline order. Here we combine the use of SAXS with cryoTEM and cryo-electron tomography (cryoET, 3D cryoTEM) to study the formation process of the 2D crystalline A(6)K nanotubes. This study reveals that the formation of these tubes in fact is a crystal growth process, involving different mechanisms depending on the conditions used. Inorganic crystals have been demonstrated to form not only through ion-by-ion addition but also through non-classical mechanisms including oriented attachment. Here we show an organic crystalline material that can form through... (More)
- Above its critical aggregation concentration the tfa salt of the peptide A(6)K self-assembles into micron long, hollow nanotubes with uniform diameters of 52 nm and crystalline order. Here we combine the use of SAXS with cryoTEM and cryo-electron tomography (cryoET, 3D cryoTEM) to study the formation process of the 2D crystalline A(6)K nanotubes. This study reveals that the formation of these tubes in fact is a crystal growth process, involving different mechanisms depending on the conditions used. Inorganic crystals have been demonstrated to form not only through ion-by-ion addition but also through non-classical mechanisms including oriented attachment. Here we show an organic crystalline material that can form through molecule-by-molecule growth as well as through oriented attachment. We discuss the mechanisms in relation to the supersaturation levels of the peptide solutions and the molecular interactions between the peptide molecules in the tubular assemblies. The proposed mechanisms are supported by semi-empirical molecular orbital calculations and time resolved dissolution experiments. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2883788
- author
- Cenker, Celen LU ; Bomans, Paul H. H. ; Friedrich, Heiner ; Dedeoglu, Burcu ; Aviyente, Viktorya ; Olsson, Ulf LU ; Sommerdijk, Nico A. J. M. and Bucak, Seyda
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Soft Matter
- volume
- 8
- issue
- 28
- pages
- 7463 - 7470
- publisher
- Royal Society of Chemistry
- external identifiers
-
- wos:000305764800019
- scopus:84869596512
- ISSN
- 1744-6848
- DOI
- 10.1039/c2sm25671a
- language
- English
- LU publication?
- yes
- id
- 082c6231-7a8c-4a16-940b-055b076e5f6f (old id 2883788)
- date added to LUP
- 2016-04-01 14:22:42
- date last changed
- 2022-04-22 02:56:47
@article{082c6231-7a8c-4a16-940b-055b076e5f6f, abstract = {{Above its critical aggregation concentration the tfa salt of the peptide A(6)K self-assembles into micron long, hollow nanotubes with uniform diameters of 52 nm and crystalline order. Here we combine the use of SAXS with cryoTEM and cryo-electron tomography (cryoET, 3D cryoTEM) to study the formation process of the 2D crystalline A(6)K nanotubes. This study reveals that the formation of these tubes in fact is a crystal growth process, involving different mechanisms depending on the conditions used. Inorganic crystals have been demonstrated to form not only through ion-by-ion addition but also through non-classical mechanisms including oriented attachment. Here we show an organic crystalline material that can form through molecule-by-molecule growth as well as through oriented attachment. We discuss the mechanisms in relation to the supersaturation levels of the peptide solutions and the molecular interactions between the peptide molecules in the tubular assemblies. The proposed mechanisms are supported by semi-empirical molecular orbital calculations and time resolved dissolution experiments.}}, author = {{Cenker, Celen and Bomans, Paul H. H. and Friedrich, Heiner and Dedeoglu, Burcu and Aviyente, Viktorya and Olsson, Ulf and Sommerdijk, Nico A. J. M. and Bucak, Seyda}}, issn = {{1744-6848}}, language = {{eng}}, number = {{28}}, pages = {{7463--7470}}, publisher = {{Royal Society of Chemistry}}, series = {{Soft Matter}}, title = {{Peptide nanotube formation: a crystal growth process}}, url = {{http://dx.doi.org/10.1039/c2sm25671a}}, doi = {{10.1039/c2sm25671a}}, volume = {{8}}, year = {{2012}}, }