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Density functional theory of equilibrium random copolymers : Application to surface adsorption of aggregating peptides

Wang, Haiqiang; Forsman, Jan LU and Woodward, Clifford E. (2016) In Journal of Physics: Condensed Matter 28(24).
Abstract

We generalize a recently developed polymer density functional theory (PDFT) for polydisperse polymer fluids to the case of equilibrium random copolymers. We show that the generalization of the PDFT to these systems allows us to obtain a remarkable simplification compared to the monodispersed polymers. The theory is used to treat a model for protein aggregation into linear filaments in the presence of surfaces. Here we show that, for attractive surfaces, there is evidence of significant enhancement of protein aggregation. This behaviour is a consequence of a surface phase transition, which has been shown to occur with ideal equilibrium polymers in the presence of sufficiently attractive surfaces. For excluding monomers, this transition... (More)

We generalize a recently developed polymer density functional theory (PDFT) for polydisperse polymer fluids to the case of equilibrium random copolymers. We show that the generalization of the PDFT to these systems allows us to obtain a remarkable simplification compared to the monodispersed polymers. The theory is used to treat a model for protein aggregation into linear filaments in the presence of surfaces. Here we show that, for attractive surfaces, there is evidence of significant enhancement of protein aggregation. This behaviour is a consequence of a surface phase transition, which has been shown to occur with ideal equilibrium polymers in the presence of sufficiently attractive surfaces. For excluding monomers, this transition is suppressed, though an echo of the underlying ideal transition is present in the sudden change in the excess adsorption.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
adsorption, copolymer, DFT
in
Journal of Physics: Condensed Matter
volume
28
issue
24
publisher
IOP Publishing
external identifiers
  • scopus:84969850820
  • wos:000376693000012
ISSN
0953-8984
DOI
10.1088/0953-8984/28/24/244011
language
English
LU publication?
yes
id
08585c6b-09cf-476a-8746-f65f140b3f84
date added to LUP
2017-02-06 08:54:43
date last changed
2017-09-18 11:36:48
@article{08585c6b-09cf-476a-8746-f65f140b3f84,
  abstract     = {<p>We generalize a recently developed polymer density functional theory (PDFT) for polydisperse polymer fluids to the case of equilibrium random copolymers. We show that the generalization of the PDFT to these systems allows us to obtain a remarkable simplification compared to the monodispersed polymers. The theory is used to treat a model for protein aggregation into linear filaments in the presence of surfaces. Here we show that, for attractive surfaces, there is evidence of significant enhancement of protein aggregation. This behaviour is a consequence of a surface phase transition, which has been shown to occur with ideal equilibrium polymers in the presence of sufficiently attractive surfaces. For excluding monomers, this transition is suppressed, though an echo of the underlying ideal transition is present in the sudden change in the excess adsorption.</p>},
  articleno    = {244011},
  author       = {Wang, Haiqiang and Forsman, Jan and Woodward, Clifford E.},
  issn         = {0953-8984},
  keyword      = {adsorption,copolymer,DFT},
  language     = {eng},
  month        = {04},
  number       = {24},
  publisher    = {IOP Publishing},
  series       = {Journal of Physics: Condensed Matter},
  title        = {Density functional theory of equilibrium random copolymers : Application to surface adsorption of aggregating peptides},
  url          = {http://dx.doi.org/10.1088/0953-8984/28/24/244011},
  volume       = {28},
  year         = {2016},
}