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Combined density and size-based sorting in deterministic lateral displacement devices

Holm, Stefan H. LU ; Beech, Jason P. LU and Tegenfeldt, Jonas O. LU (2013) 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 2. p.1224-1226
Abstract

We present a deterministic-lateral-displacement (DLD) device that extends the capabilities of this traditionally sizebased particle separation technique to also be sensitive to density. By the use of T-shaped posts instead of the normally cylindrical posts the particle trajectory through the device will be a function of its vertical position which in turn is determined by the buoyancy of the particles. The potential lies in fast sorting of complex biological samples together with diagnosis and treatment-monitoring of diseases affecting cell-density, eg. cancer, sickle-cell anemia and malaria. We demonstrate proof-of-principle of combined size-and-density-based sorting, specifically particles of identical size but different density.

Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Density, Deterministic lateral displacement, Fractionation
host publication
17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
volume
2
pages
3 pages
publisher
Chemical and Biological Microsystems Society
conference name
17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
conference location
Freiburg, Germany
conference dates
2013-10-27 - 2013-10-31
external identifiers
  • scopus:84907300362
ISBN
9781632666246
language
English
LU publication?
yes
id
085889a4-5c38-4110-9117-00f2df27749e
date added to LUP
2018-10-20 08:42:32
date last changed
2019-08-06 03:07:33
@inproceedings{085889a4-5c38-4110-9117-00f2df27749e,
  abstract     = {<p>We present a deterministic-lateral-displacement (DLD) device that extends the capabilities of this traditionally sizebased particle separation technique to also be sensitive to density. By the use of T-shaped posts instead of the normally cylindrical posts the particle trajectory through the device will be a function of its vertical position which in turn is determined by the buoyancy of the particles. The potential lies in fast sorting of complex biological samples together with diagnosis and treatment-monitoring of diseases affecting cell-density, eg. cancer, sickle-cell anemia and malaria. We demonstrate proof-of-principle of combined size-and-density-based sorting, specifically particles of identical size but different density.</p>},
  author       = {Holm, Stefan H. and Beech, Jason P. and Tegenfeldt, Jonas O.},
  isbn         = {9781632666246},
  keyword      = {Density,Deterministic lateral displacement,Fractionation},
  language     = {eng},
  location     = {Freiburg, Germany},
  month        = {01},
  pages        = {1224--1226},
  publisher    = {Chemical and Biological Microsystems Society},
  title        = {Combined density and size-based sorting in deterministic lateral displacement devices},
  volume       = {2},
  year         = {2013},
}