Type I interferon signaling in dendritic cells stimulates the development of lymph-node-resident T follicular helper cells.
(2009) In Immunity 31(3). p.491-501- Abstract
- T follicular helper (Tfh) cells represent a recently defined CD4(+) T cell subset characterized by the expression of the chemokine receptor CXCR5 and an enhanced ability to support B cells to mount antibody responses. Here, we demonstrate that lymph-node-resident CXCR5(+) Tfh cells and gut-homing integrin alpha(4)beta(7)-expressing T helper cells are generated as separate subsets in the gut-draining mesenteric lymph nodes. Type I interferon signaling in dendritic cells and in nonhematopoietic cells selectively stimulates Tfh cell development in response to antigen in conjunction with Toll-like receptor (TLR)3 or TLR4 agonists. Consistent with this, the ability of dendritic cells to produce the cytokine IL-6, required for in vivo Tfh... (More)
- T follicular helper (Tfh) cells represent a recently defined CD4(+) T cell subset characterized by the expression of the chemokine receptor CXCR5 and an enhanced ability to support B cells to mount antibody responses. Here, we demonstrate that lymph-node-resident CXCR5(+) Tfh cells and gut-homing integrin alpha(4)beta(7)-expressing T helper cells are generated as separate subsets in the gut-draining mesenteric lymph nodes. Type I interferon signaling in dendritic cells and in nonhematopoietic cells selectively stimulates Tfh cell development in response to antigen in conjunction with Toll-like receptor (TLR)3 or TLR4 agonists. Consistent with this, the ability of dendritic cells to produce the cytokine IL-6, required for in vivo Tfh differentiation, and antibody affinity maturation are both reduced in absence of type I interferon signaling. Thus, our results identify type I interferon as a natural adjuvant that selectively supports the generation of lymph node resident Tfh cells. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1483731
- author
- Cucak, Helena LU ; Yrlid, Ulf ; Reizis, Boris ; Kalinke, Ulrich and Johansson Lindbom, Bengt LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Helper-Inducer: metabolism, T-Lymphocytes, Receptor, Interferon alpha-beta: immunology, Receptors, CXCR5: metabolism, Helper-Inducer: cytology, Helper-Inducer: immunology, Interferon alpha-beta: genetics, Interferon alpha-beta: deficiency, Lymph Nodes: metabolism, Lymph Nodes: immunology, Lymph Nodes: cytology, Interleukin-6: biosynthesis, Interferon Type I: immunology, Integrins: metabolism, CD11c: immunology, Antigens, Dendritic Cells: immunology
- in
- Immunity
- volume
- 31
- issue
- 3
- pages
- 491 - 501
- publisher
- Cell Press
- external identifiers
-
- wos:000270525900016
- pmid:19733096
- scopus:70249131137
- pmid:19733096
- ISSN
- 1074-7613
- DOI
- 10.1016/j.immuni.2009.07.005
- language
- English
- LU publication?
- yes
- id
- 088d5356-6101-4d46-b3b2-399f55bcf0db (old id 1483731)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19733096?dopt=Abstract
- date added to LUP
- 2016-04-04 07:07:14
- date last changed
- 2020-12-16 01:33:50
@article{088d5356-6101-4d46-b3b2-399f55bcf0db, abstract = {T follicular helper (Tfh) cells represent a recently defined CD4(+) T cell subset characterized by the expression of the chemokine receptor CXCR5 and an enhanced ability to support B cells to mount antibody responses. Here, we demonstrate that lymph-node-resident CXCR5(+) Tfh cells and gut-homing integrin alpha(4)beta(7)-expressing T helper cells are generated as separate subsets in the gut-draining mesenteric lymph nodes. Type I interferon signaling in dendritic cells and in nonhematopoietic cells selectively stimulates Tfh cell development in response to antigen in conjunction with Toll-like receptor (TLR)3 or TLR4 agonists. Consistent with this, the ability of dendritic cells to produce the cytokine IL-6, required for in vivo Tfh differentiation, and antibody affinity maturation are both reduced in absence of type I interferon signaling. Thus, our results identify type I interferon as a natural adjuvant that selectively supports the generation of lymph node resident Tfh cells.}, author = {Cucak, Helena and Yrlid, Ulf and Reizis, Boris and Kalinke, Ulrich and Johansson Lindbom, Bengt}, issn = {1074-7613}, language = {eng}, number = {3}, pages = {491--501}, publisher = {Cell Press}, series = {Immunity}, title = {Type I interferon signaling in dendritic cells stimulates the development of lymph-node-resident T follicular helper cells.}, url = {http://dx.doi.org/10.1016/j.immuni.2009.07.005}, doi = {10.1016/j.immuni.2009.07.005}, volume = {31}, year = {2009}, }