Laminin {alpha}1 chain improves laminin {alpha}2 chain deficient peripheral neuropathy.
(2006) In Human Molecular Genetics 15(18). p.2690-2700- Abstract
- Absence of laminin alpha2 chain leads to a severe form of congenital muscular dystrophy (MDC1A) associated with peripheral neuropathy. Hence, future therapies should be aimed at alleviating both muscle and neurological dysfunctions. Pre-clinical studies in animal models have mainly focused on ameliorating the muscle phenotype. Here we show that transgenic expression of laminin alpha1 chain in muscles and the peripheral nervous system of laminin alpha2 chain deficient mice reduced muscular dystrophy and largely corrected the peripheral nerve defects. The presence of laminin alpha1 chain in the peripheral nervous system resulted in near-normal myelination, restored Schwann cell basement membranes and improved rotarod performance. In summary,... (More)
- Absence of laminin alpha2 chain leads to a severe form of congenital muscular dystrophy (MDC1A) associated with peripheral neuropathy. Hence, future therapies should be aimed at alleviating both muscle and neurological dysfunctions. Pre-clinical studies in animal models have mainly focused on ameliorating the muscle phenotype. Here we show that transgenic expression of laminin alpha1 chain in muscles and the peripheral nervous system of laminin alpha2 chain deficient mice reduced muscular dystrophy and largely corrected the peripheral nerve defects. The presence of laminin alpha1 chain in the peripheral nervous system resulted in near-normal myelination, restored Schwann cell basement membranes and improved rotarod performance. In summary, we postulate that laminin alpha1 chain is an excellent substitute for laminin alpha2 chain in multiple tissues and suggest that treatment with laminin alpha1 chain may be beneficial for MDC1A in humans. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/160231
- author
- Gawlik, Kinga LU ; Li, Jia-Yi LU ; Petersén, Åsa LU and Durbeej-Hjalt, Madeleine LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Human Molecular Genetics
- volume
- 15
- issue
- 18
- pages
- 2690 - 2700
- publisher
- Oxford University Press
- external identifiers
-
- wos:000240590400004
- pmid:16893907
- scopus:33748750613
- pmid:16893907
- ISSN
- 0964-6906
- DOI
- 10.1093/hmg/ddl201
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041), Muscle biology (013212015)
- id
- 088fc5c3-1076-45e7-8dbc-5c13fb5304ba (old id 160231)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16893907&dopt=Abstract
- date added to LUP
- 2016-04-01 12:22:49
- date last changed
- 2022-03-29 00:08:01
@article{088fc5c3-1076-45e7-8dbc-5c13fb5304ba,
abstract = {{Absence of laminin alpha2 chain leads to a severe form of congenital muscular dystrophy (MDC1A) associated with peripheral neuropathy. Hence, future therapies should be aimed at alleviating both muscle and neurological dysfunctions. Pre-clinical studies in animal models have mainly focused on ameliorating the muscle phenotype. Here we show that transgenic expression of laminin alpha1 chain in muscles and the peripheral nervous system of laminin alpha2 chain deficient mice reduced muscular dystrophy and largely corrected the peripheral nerve defects. The presence of laminin alpha1 chain in the peripheral nervous system resulted in near-normal myelination, restored Schwann cell basement membranes and improved rotarod performance. In summary, we postulate that laminin alpha1 chain is an excellent substitute for laminin alpha2 chain in multiple tissues and suggest that treatment with laminin alpha1 chain may be beneficial for MDC1A in humans.}},
author = {{Gawlik, Kinga and Li, Jia-Yi and Petersén, Åsa and Durbeej-Hjalt, Madeleine}},
issn = {{0964-6906}},
language = {{eng}},
number = {{18}},
pages = {{2690--2700}},
publisher = {{Oxford University Press}},
series = {{Human Molecular Genetics}},
title = {{Laminin {alpha}1 chain improves laminin {alpha}2 chain deficient peripheral neuropathy.}},
url = {{http://dx.doi.org/10.1093/hmg/ddl201}},
doi = {{10.1093/hmg/ddl201}},
volume = {{15}},
year = {{2006}},
}