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Pancreatic cancer : Disease dynamics, tumor biology and the role of the microenvironment

Ansari, Daniel LU ; Friess, Helmut; Bauden, Monika LU ; Samnegård, Johan and Andersson, Roland LU (2018) In Oncotarget 9(5). p.6644-6651
Abstract

Pancreatic cancer is known for its propensity to metastasize. Recent studies have challenged the commonly held belief that pancreatic cancer is a stepwise process, where tumor cells disseminate late in primary tumor development. Instead it has been suggested that pancreatic tumor cells may disseminate early and develop independently and in parallel to the primary tumor. Circulating tumor cells can be found in most patients with pancreatic cancer, even in those with localized stage. Also, recent phylogenetic analyses have revealed evidence for a branched evolution where metastatic lineages can develop early in tumor development. In this Review, we discuss current models of pancreatic cancer progression and the importance of the tumor... (More)

Pancreatic cancer is known for its propensity to metastasize. Recent studies have challenged the commonly held belief that pancreatic cancer is a stepwise process, where tumor cells disseminate late in primary tumor development. Instead it has been suggested that pancreatic tumor cells may disseminate early and develop independently and in parallel to the primary tumor. Circulating tumor cells can be found in most patients with pancreatic cancer, even in those with localized stage. Also, recent phylogenetic analyses have revealed evidence for a branched evolution where metastatic lineages can develop early in tumor development. In this Review, we discuss current models of pancreatic cancer progression and the importance of the tumor microenvironment, in order to better understand the recalcitrant nature of this disease.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Disease dynamics, Microenvironment, Pancreatic cancer, Tumor biology
in
Oncotarget
volume
9
issue
5
pages
8 pages
publisher
Impact Journals, LLC
external identifiers
  • scopus:85040640894
ISSN
1949-2553
DOI
language
English
LU publication?
yes
id
08b95004-3a41-43ac-af7b-69a92d776c32
date added to LUP
2018-02-23 19:13:11
date last changed
2018-06-10 05:27:11
@article{08b95004-3a41-43ac-af7b-69a92d776c32,
  abstract     = {<p>Pancreatic cancer is known for its propensity to metastasize. Recent studies have challenged the commonly held belief that pancreatic cancer is a stepwise process, where tumor cells disseminate late in primary tumor development. Instead it has been suggested that pancreatic tumor cells may disseminate early and develop independently and in parallel to the primary tumor. Circulating tumor cells can be found in most patients with pancreatic cancer, even in those with localized stage. Also, recent phylogenetic analyses have revealed evidence for a branched evolution where metastatic lineages can develop early in tumor development. In this Review, we discuss current models of pancreatic cancer progression and the importance of the tumor microenvironment, in order to better understand the recalcitrant nature of this disease.</p>},
  author       = {Ansari, Daniel and Friess, Helmut and Bauden, Monika and Samnegård, Johan and Andersson, Roland},
  issn         = {1949-2553},
  keyword      = {Disease dynamics,Microenvironment,Pancreatic cancer,Tumor biology},
  language     = {eng},
  number       = {5},
  pages        = {6644--6651},
  publisher    = {Impact Journals, LLC},
  series       = {Oncotarget},
  title        = {Pancreatic cancer : Disease dynamics, tumor biology and the role of the microenvironment},
  url          = {http://dx.doi.org/},
  volume       = {9},
  year         = {2018},
}