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Risk of metabolic disorders in childless men : A population-based cohort study

Bungum, Ane Berger LU ; Glazer, Clara Helene; Bonde, Jens Peter; Nilsson, Peter M. LU ; Giwercman, Aleksander LU and Tøttenborg, Sandra Søgaard (2018) In BMJ Open 8(8).
Abstract

Objective To study whether male childlessness is associated with an increased risk of metabolic disorders such as metabolic syndrome (MetS) and diabetes. Design A population-based cohort study. Setting Not applicable. Participants 2572 men from the population-based Malmö Diet and Cancer Cardiovascular Cohort. Interventions None. Main outcome measures From cross-sectional analyses, main outcome measures were ORs and 95% CIs for MetS and diabetes among childless men. In prospective analyses, HRs and 95% CI for diabetes among childless men. Results At baseline, in men with a mean age of 57 years, the prevalence of MetS was 26% and 22% among childless men and fathers, respectively. Similarly, we observed a higher prevalence of diabetes of... (More)

Objective To study whether male childlessness is associated with an increased risk of metabolic disorders such as metabolic syndrome (MetS) and diabetes. Design A population-based cohort study. Setting Not applicable. Participants 2572 men from the population-based Malmö Diet and Cancer Cardiovascular Cohort. Interventions None. Main outcome measures From cross-sectional analyses, main outcome measures were ORs and 95% CIs for MetS and diabetes among childless men. In prospective analyses, HRs and 95% CI for diabetes among childless men. Results At baseline, in men with a mean age of 57 years, the prevalence of MetS was 26% and 22% among childless men and fathers, respectively. Similarly, we observed a higher prevalence of diabetes of 11% among childless men compared with 5% among fathers. In the cross-sectional adjusted analyses, childless men had a higher risk of MetS and diabetes, with ORs of 1.22 (95% CI 0.87 to 1.72) and 2.12 (95% CI 1.34 to 3.36) compared with fathers. In the prospective analysis, during a mean follow-up of 18.3 years, we did not see any increase in diabetes risk among childless men (HR 1.02 (0.76 to 1.37)). Conclusion This study provides evidence of an association between male childlessness and a higher risk of MetS and diabetes. However, as these associations were found in cross-sectional analyses, reverse causation cannot be excluded.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
childlessness, diabetes, infertility, metabolic syndrome, register-based cohort study
in
BMJ Open
volume
8
issue
8
publisher
British Medical Journal Publishing Group
external identifiers
  • scopus:85051981702
ISSN
2044-6055
DOI
10.1136/bmjopen-2017-020293
language
English
LU publication?
yes
id
08d3421b-b3d4-47e5-86b0-9ca0c38f30d8
date added to LUP
2018-10-17 14:19:48
date last changed
2019-03-26 15:46:53
@article{08d3421b-b3d4-47e5-86b0-9ca0c38f30d8,
  abstract     = {<p>Objective To study whether male childlessness is associated with an increased risk of metabolic disorders such as metabolic syndrome (MetS) and diabetes. Design A population-based cohort study. Setting Not applicable. Participants 2572 men from the population-based Malmö Diet and Cancer Cardiovascular Cohort. Interventions None. Main outcome measures From cross-sectional analyses, main outcome measures were ORs and 95% CIs for MetS and diabetes among childless men. In prospective analyses, HRs and 95% CI for diabetes among childless men. Results At baseline, in men with a mean age of 57 years, the prevalence of MetS was 26% and 22% among childless men and fathers, respectively. Similarly, we observed a higher prevalence of diabetes of 11% among childless men compared with 5% among fathers. In the cross-sectional adjusted analyses, childless men had a higher risk of MetS and diabetes, with ORs of 1.22 (95% CI 0.87 to 1.72) and 2.12 (95% CI 1.34 to 3.36) compared with fathers. In the prospective analysis, during a mean follow-up of 18.3 years, we did not see any increase in diabetes risk among childless men (HR 1.02 (0.76 to 1.37)). Conclusion This study provides evidence of an association between male childlessness and a higher risk of MetS and diabetes. However, as these associations were found in cross-sectional analyses, reverse causation cannot be excluded.</p>},
  articleno    = {020293},
  author       = {Bungum, Ane Berger and Glazer, Clara Helene and Bonde, Jens Peter and Nilsson, Peter M. and Giwercman, Aleksander and Tøttenborg, Sandra Søgaard},
  issn         = {2044-6055},
  keyword      = {childlessness,diabetes,infertility,metabolic syndrome,register-based cohort study},
  language     = {eng},
  month        = {08},
  number       = {8},
  publisher    = {British Medical Journal Publishing Group},
  series       = {BMJ Open},
  title        = {Risk of metabolic disorders in childless men : A population-based cohort study},
  url          = {http://dx.doi.org/10.1136/bmjopen-2017-020293},
  volume       = {8},
  year         = {2018},
}