The Multiple Silicone Tube Device, "Tubes within a Tube," for Multiplication in Nerve Reconstruction.
Johansson, Fredrik and Dahlin, Lars LU
(2014)
In BioMed Research International
2014(Apr 17).
- Abstract
- Multiple nerve branches were created during the regeneration procedure after a nerve injury and such multiple branches are suggested to be used to control, for example, prosthesis with many degrees of freedom. Transected rat sciatic nerve stumps were inserted into a nine mm long silicone tube, which contained four, five mm long, smaller tubes, thus leaving a five mm gap for regenerating nerve fibers. Six weeks later, several new nerve structures were formed not only in the four smaller tubes, but also in the spaces in-between. The 7-9 new continuous nerve structures, which were isolated as individual free nerves after removal of the tubes, were delineated by a perineurium and contained both myelinated and unmyelinated nerve fibers as well... (More)
- Multiple nerve branches were created during the regeneration procedure after a nerve injury and such multiple branches are suggested to be used to control, for example, prosthesis with many degrees of freedom. Transected rat sciatic nerve stumps were inserted into a nine mm long silicone tube, which contained four, five mm long, smaller tubes, thus leaving a five mm gap for regenerating nerve fibers. Six weeks later, several new nerve structures were formed not only in the four smaller tubes, but also in the spaces in-between. The 7-9 new continuous nerve structures, which were isolated as individual free nerves after removal of the tubes, were delineated by a perineurium and contained both myelinated and unmyelinated nerve fibers as well as blood vessels. Stimulation of the proximal nerve elicited contractions in distal muscles. Thin metal electrodes, inserted initially into the smaller tubes in some experiments, became embedded in the new nerve structures and when stimulated contractions of the distal muscles were observed. The "tubes within a tube" technique, creating multiple new nerves from a single "mother" nerve, can be used to record multiple signals for prosthetic device control or as sources for supply of multiple denervated targets. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4452518
- author
- Johansson, Fredrik
and Dahlin, Lars
LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- BioMed Research International
- volume
- 2014
- issue
- Apr 17
- article number
- 689127
- publisher
- Hindawi Limited
- external identifiers
-
- pmid:24864255
- wos:000335050300001
- scopus:84900003499
- pmid:24864255
- ISSN
- 2314-6133
- DOI
- 10.1155/2014/689127
- language
- English
- LU publication?
- yes
- id
- 09166a35-149f-4c4b-acb0-be554565940a (old id 4452518)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24864255?dopt=Abstract
- date added to LUP
- 2016-04-01 10:31:22
- date last changed
- 2022-03-27 17:06:09
@article{09166a35-149f-4c4b-acb0-be554565940a,
abstract = {{Multiple nerve branches were created during the regeneration procedure after a nerve injury and such multiple branches are suggested to be used to control, for example, prosthesis with many degrees of freedom. Transected rat sciatic nerve stumps were inserted into a nine mm long silicone tube, which contained four, five mm long, smaller tubes, thus leaving a five mm gap for regenerating nerve fibers. Six weeks later, several new nerve structures were formed not only in the four smaller tubes, but also in the spaces in-between. The 7-9 new continuous nerve structures, which were isolated as individual free nerves after removal of the tubes, were delineated by a perineurium and contained both myelinated and unmyelinated nerve fibers as well as blood vessels. Stimulation of the proximal nerve elicited contractions in distal muscles. Thin metal electrodes, inserted initially into the smaller tubes in some experiments, became embedded in the new nerve structures and when stimulated contractions of the distal muscles were observed. The "tubes within a tube" technique, creating multiple new nerves from a single "mother" nerve, can be used to record multiple signals for prosthetic device control or as sources for supply of multiple denervated targets.}},
author = {{Johansson, Fredrik and Dahlin, Lars}},
issn = {{2314-6133}},
language = {{eng}},
number = {{Apr 17}},
publisher = {{Hindawi Limited}},
series = {{BioMed Research International}},
title = {{The Multiple Silicone Tube Device, "Tubes within a Tube," for Multiplication in Nerve Reconstruction.}},
url = {{https://lup.lub.lu.se/search/files/1913837/5046879.pdf}},
doi = {{10.1155/2014/689127}},
volume = {{2014}},
year = {{2014}},
}