Predictive biomarkers in radioresistant rectal cancer : A systematic review
(2023) In Critical Reviews in Oncology/Hematology 186.- Abstract
Background and aims: The treatment of locally advanced rectal cancer often consists of neoadjuvant chemoradiotherapy followed by surgery. However, approximately 15% of patients show no response to this neoadjuvant chemoradiotherapy. This systematic review aimed to identify biomarkers of innate radioresistant rectal cancer. Method: Through a systematic literature search, 125 papers were included and analyzed using ROBINS-I, a Cochrane risk of bias tool for non-randomized studies of interventions. Both statistically significant and nonsignificant biomarkers were identified. Biomarkers mentioned more than once in the results or biomarkers with a low or moderate risk of bias were included as the final results. Results: Thirteen unique... (More)
Background and aims: The treatment of locally advanced rectal cancer often consists of neoadjuvant chemoradiotherapy followed by surgery. However, approximately 15% of patients show no response to this neoadjuvant chemoradiotherapy. This systematic review aimed to identify biomarkers of innate radioresistant rectal cancer. Method: Through a systematic literature search, 125 papers were included and analyzed using ROBINS-I, a Cochrane risk of bias tool for non-randomized studies of interventions. Both statistically significant and nonsignificant biomarkers were identified. Biomarkers mentioned more than once in the results or biomarkers with a low or moderate risk of bias were included as the final results. Results: Thirteen unique biomarkers, three genetic signatures, one specific pathway, and two combinations of two or four biomarkers were identified. In particular, the connection between HMGCS2, COASY, and PI3K-pathway seems promising. Future scientific research should focus on further validating these genetic resistance markers.
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- author
- Slipsager, Anna ; Henrichsen, Sofie N. ; Falkmer, Ursula G. ; Dybkær, Karen ; Belting, Mattias LU and Poulsen, Laurids
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Molecular biomarker, Neoadjuvant therapy, Radiotherapy, Rectal Neoplasms, Resistance
- in
- Critical Reviews in Oncology/Hematology
- volume
- 186
- article number
- 103991
- publisher
- Elsevier
- external identifiers
-
- pmid:37059272
- scopus:85152905259
- ISSN
- 1040-8428
- DOI
- 10.1016/j.critrevonc.2023.103991
- language
- English
- LU publication?
- yes
- id
- 095250d0-73d2-4220-afe9-913669d23de4
- date added to LUP
- 2023-06-20 14:42:21
- date last changed
- 2024-04-19 23:01:08
@article{095250d0-73d2-4220-afe9-913669d23de4, abstract = {{<p>Background and aims: The treatment of locally advanced rectal cancer often consists of neoadjuvant chemoradiotherapy followed by surgery. However, approximately 15% of patients show no response to this neoadjuvant chemoradiotherapy. This systematic review aimed to identify biomarkers of innate radioresistant rectal cancer. Method: Through a systematic literature search, 125 papers were included and analyzed using ROBINS-I, a Cochrane risk of bias tool for non-randomized studies of interventions. Both statistically significant and nonsignificant biomarkers were identified. Biomarkers mentioned more than once in the results or biomarkers with a low or moderate risk of bias were included as the final results. Results: Thirteen unique biomarkers, three genetic signatures, one specific pathway, and two combinations of two or four biomarkers were identified. In particular, the connection between HMGCS2, COASY, and PI3K-pathway seems promising. Future scientific research should focus on further validating these genetic resistance markers.</p>}}, author = {{Slipsager, Anna and Henrichsen, Sofie N. and Falkmer, Ursula G. and Dybkær, Karen and Belting, Mattias and Poulsen, Laurids}}, issn = {{1040-8428}}, keywords = {{Molecular biomarker; Neoadjuvant therapy; Radiotherapy; Rectal Neoplasms; Resistance}}, language = {{eng}}, publisher = {{Elsevier}}, series = {{Critical Reviews in Oncology/Hematology}}, title = {{Predictive biomarkers in radioresistant rectal cancer : A systematic review}}, url = {{http://dx.doi.org/10.1016/j.critrevonc.2023.103991}}, doi = {{10.1016/j.critrevonc.2023.103991}}, volume = {{186}}, year = {{2023}}, }