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Polymorphisms in α- And β-adrenergic receptor genes, hypertension, and obstructive sleep apnea : The skaraborg sleep study

Bengtsson Boström, Kristina LU ; Hedner, Jan; Grote, Ludger; Melander, Olle LU ; Von Wowern, Fredrik; Råstam, Lennart LU ; Groop, Leif LU and Lindblad, Ulf LU (2010) In International Journal of Hypertension 2010.
Abstract

The sympathetic nervous system and the adrenergic receptors play an important role in regulation of blood pressure. This study explored the associations between functional polymorphisms of the α 2B -, β 1 -, and β 2 -adrenergic receptor genes and obstructive sleep apnea (OSA) in hypertensive patients and hypertension in patients with OSA in a populationbased sample of 157 hypertensive patients and 181 healthy control subjects. Only the Arg389Gly polymorphism of the β 1 -adrenergic receptor gene was associated with increased risk for mild OSA in hypertensive patients (Arg/Arg versus Gly/Arg/Gly/Gly, 2.1, 95% CI, 1.02-4.7). Hypertensive men carrying the Arg389Arg genotype had higher crude and... (More)

The sympathetic nervous system and the adrenergic receptors play an important role in regulation of blood pressure. This study explored the associations between functional polymorphisms of the α 2B -, β 1 -, and β 2 -adrenergic receptor genes and obstructive sleep apnea (OSA) in hypertensive patients and hypertension in patients with OSA in a populationbased sample of 157 hypertensive patients and 181 healthy control subjects. Only the Arg389Gly polymorphism of the β 1 -adrenergic receptor gene was associated with increased risk for mild OSA in hypertensive patients (Arg/Arg versus Gly/Arg/Gly/Gly, 2.1, 95% CI, 1.02-4.7). Hypertensive men carrying the Arg389Arg genotype had higher crude and age-adjusted AHI than carriers of the Arg389Gly/Gly389Gly genotypes. When adjusted also for BMI this difference became borderline significant. This difference was not observed in women. The risk of hypertension in mild OSA was associated with increasing number of Arg-alleles (Arg/Arg OR 5.4, 95 CI 1.4-21.2).

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Hypertension
volume
2010
publisher
Hindawi Publishing Corporation
external identifiers
  • scopus:84868266888
ISSN
2090-0384
DOI
10.4061/2010/458410
language
English
LU publication?
yes
id
09c680ab-bf94-4284-b612-107787ac9a53
date added to LUP
2018-10-01 13:35:54
date last changed
2019-02-20 11:28:38
@article{09c680ab-bf94-4284-b612-107787ac9a53,
  abstract     = {<p>The sympathetic nervous system and the adrenergic receptors play an important role in regulation of blood pressure. This study explored the associations between functional polymorphisms of the α <sub>2B</sub> -, β <sub>1</sub> -, and β <sub>2</sub> -adrenergic receptor genes and obstructive sleep apnea (OSA) in hypertensive patients and hypertension in patients with OSA in a populationbased sample of 157 hypertensive patients and 181 healthy control subjects. Only the Arg389Gly polymorphism of the β <sub>1</sub> -adrenergic receptor gene was associated with increased risk for mild OSA in hypertensive patients (Arg/Arg versus Gly/Arg/Gly/Gly, 2.1, 95% CI, 1.02-4.7). Hypertensive men carrying the Arg389Arg genotype had higher crude and age-adjusted AHI than carriers of the Arg389Gly/Gly389Gly genotypes. When adjusted also for BMI this difference became borderline significant. This difference was not observed in women. The risk of hypertension in mild OSA was associated with increasing number of Arg-alleles (Arg/Arg OR 5.4, 95 CI 1.4-21.2).</p>},
  articleno    = {458410},
  author       = {Bengtsson Boström, Kristina and Hedner, Jan and Grote, Ludger and Melander, Olle and Von Wowern, Fredrik and Råstam, Lennart and Groop, Leif and Lindblad, Ulf},
  issn         = {2090-0384},
  language     = {eng},
  month        = {12},
  publisher    = {Hindawi Publishing Corporation},
  series       = {International Journal of Hypertension},
  title        = {Polymorphisms in α- And β-adrenergic receptor genes, hypertension, and obstructive sleep apnea : The skaraborg sleep study},
  url          = {http://dx.doi.org/10.4061/2010/458410},
  volume       = {2010},
  year         = {2010},
}