Polymorphisms in α- And β-adrenergic receptor genes, hypertension, and obstructive sleep apnea : The skaraborg sleep study
(2010) In International Journal of Hypertension 2010.- Abstract
The sympathetic nervous system and the adrenergic receptors play an important role in regulation of blood pressure. This study explored the associations between functional polymorphisms of the α 2B -, β 1 -, and β 2 -adrenergic receptor genes and obstructive sleep apnea (OSA) in hypertensive patients and hypertension in patients with OSA in a populationbased sample of 157 hypertensive patients and 181 healthy control subjects. Only the Arg389Gly polymorphism of the β 1 -adrenergic receptor gene was associated with increased risk for mild OSA in hypertensive patients (Arg/Arg versus Gly/Arg/Gly/Gly, 2.1, 95% CI, 1.02-4.7). Hypertensive men carrying the Arg389Arg genotype had higher crude and... (More)
The sympathetic nervous system and the adrenergic receptors play an important role in regulation of blood pressure. This study explored the associations between functional polymorphisms of the α 2B -, β 1 -, and β 2 -adrenergic receptor genes and obstructive sleep apnea (OSA) in hypertensive patients and hypertension in patients with OSA in a populationbased sample of 157 hypertensive patients and 181 healthy control subjects. Only the Arg389Gly polymorphism of the β 1 -adrenergic receptor gene was associated with increased risk for mild OSA in hypertensive patients (Arg/Arg versus Gly/Arg/Gly/Gly, 2.1, 95% CI, 1.02-4.7). Hypertensive men carrying the Arg389Arg genotype had higher crude and age-adjusted AHI than carriers of the Arg389Gly/Gly389Gly genotypes. When adjusted also for BMI this difference became borderline significant. This difference was not observed in women. The risk of hypertension in mild OSA was associated with increasing number of Arg-alleles (Arg/Arg OR 5.4, 95 CI 1.4-21.2).
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- author
- Bengtsson Boström, Kristina LU ; Hedner, Jan ; Grote, Ludger ; Melander, Olle LU ; Von Wowern, Fredrik ; Råstam, Lennart LU ; Groop, Leif LU and Lindblad, Ulf LU
- organization
- publishing date
- 2010-12-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- International Journal of Hypertension
- volume
- 2010
- article number
- 458410
- publisher
- Hindawi Limited
- external identifiers
-
- scopus:84868266888
- ISSN
- 2090-0384
- DOI
- 10.4061/2010/458410
- language
- English
- LU publication?
- yes
- id
- 09c680ab-bf94-4284-b612-107787ac9a53
- date added to LUP
- 2018-10-01 13:35:54
- date last changed
- 2024-04-15 12:27:22
@article{09c680ab-bf94-4284-b612-107787ac9a53, abstract = {{<p>The sympathetic nervous system and the adrenergic receptors play an important role in regulation of blood pressure. This study explored the associations between functional polymorphisms of the α <sub>2B</sub> -, β <sub>1</sub> -, and β <sub>2</sub> -adrenergic receptor genes and obstructive sleep apnea (OSA) in hypertensive patients and hypertension in patients with OSA in a populationbased sample of 157 hypertensive patients and 181 healthy control subjects. Only the Arg389Gly polymorphism of the β <sub>1</sub> -adrenergic receptor gene was associated with increased risk for mild OSA in hypertensive patients (Arg/Arg versus Gly/Arg/Gly/Gly, 2.1, 95% CI, 1.02-4.7). Hypertensive men carrying the Arg389Arg genotype had higher crude and age-adjusted AHI than carriers of the Arg389Gly/Gly389Gly genotypes. When adjusted also for BMI this difference became borderline significant. This difference was not observed in women. The risk of hypertension in mild OSA was associated with increasing number of Arg-alleles (Arg/Arg OR 5.4, 95 CI 1.4-21.2).</p>}}, author = {{Bengtsson Boström, Kristina and Hedner, Jan and Grote, Ludger and Melander, Olle and Von Wowern, Fredrik and Råstam, Lennart and Groop, Leif and Lindblad, Ulf}}, issn = {{2090-0384}}, language = {{eng}}, month = {{12}}, publisher = {{Hindawi Limited}}, series = {{International Journal of Hypertension}}, title = {{Polymorphisms in α- And β-adrenergic receptor genes, hypertension, and obstructive sleep apnea : The skaraborg sleep study}}, url = {{http://dx.doi.org/10.4061/2010/458410}}, doi = {{10.4061/2010/458410}}, volume = {{2010}}, year = {{2010}}, }