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Extracellular matrix composition defines an ultra-high-risk group of neuroblastoma within the high-risk patient cohort

Tadeo, Irene; Berbegall, Ana P.; Castel, Victoria; García-Miguel, Purificación; Callaghan, Robert; Påhlman, Sven LU ; Navarro, Samuel and Noguera, Rosa (2016) In British Journal of Cancer 115(4). p.480-489
Abstract

Background:Although survival for neuroblastoma patients has dramatically improved in recent years, a substantial number of children in the high-risk subgroup still die.Methods:We aimed to define a subgroup of ultra-high-risk patients from within the high-risk cohort. We used advanced morphometric approaches to quantify and characterise blood vessels, reticulin fibre networks, collagen type I bundles, elastic fibres and glycosaminoglycans in 102 high-risk neuroblastomas specimens. The Kaplan-Meier method was used to correlate the analysed elements with survival.Results:The organisation of blood vessels and reticulin fibres in neuroblastic tumours defined an ultra-high-risk patient subgroup with 5-year survival rate <15%. Specifically,... (More)

Background:Although survival for neuroblastoma patients has dramatically improved in recent years, a substantial number of children in the high-risk subgroup still die.Methods:We aimed to define a subgroup of ultra-high-risk patients from within the high-risk cohort. We used advanced morphometric approaches to quantify and characterise blood vessels, reticulin fibre networks, collagen type I bundles, elastic fibres and glycosaminoglycans in 102 high-risk neuroblastomas specimens. The Kaplan-Meier method was used to correlate the analysed elements with survival.Results:The organisation of blood vessels and reticulin fibres in neuroblastic tumours defined an ultra-high-risk patient subgroup with 5-year survival rate <15%. Specifically, tumours with irregularly shaped blood vessels, large sinusoid-like vessels, smaller and tortuous venules and arterioles and with large areas of reticulin fibres forming large, crosslinking, branching and haphazardly arranged networks were linked to the ultra-high-risk phenotype.Conclusions:We demonstrate that quantification of tumour stroma components by morphometric techniques has the potential to improve risk stratification of neuroblastoma patients.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Cancer
volume
115
issue
4
pages
10 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:84978473807
  • wos:000381302700011
ISSN
0007-0920
DOI
10.1038/bjc.2016.210
language
English
LU publication?
yes
id
0ac2e0c3-ecb0-4d3a-a42a-2656b4c8de69
date added to LUP
2016-12-29 13:12:42
date last changed
2017-09-18 11:34:13
@article{0ac2e0c3-ecb0-4d3a-a42a-2656b4c8de69,
  abstract     = {<p>Background:Although survival for neuroblastoma patients has dramatically improved in recent years, a substantial number of children in the high-risk subgroup still die.Methods:We aimed to define a subgroup of ultra-high-risk patients from within the high-risk cohort. We used advanced morphometric approaches to quantify and characterise blood vessels, reticulin fibre networks, collagen type I bundles, elastic fibres and glycosaminoglycans in 102 high-risk neuroblastomas specimens. The Kaplan-Meier method was used to correlate the analysed elements with survival.Results:The organisation of blood vessels and reticulin fibres in neuroblastic tumours defined an ultra-high-risk patient subgroup with 5-year survival rate &lt;15%. Specifically, tumours with irregularly shaped blood vessels, large sinusoid-like vessels, smaller and tortuous venules and arterioles and with large areas of reticulin fibres forming large, crosslinking, branching and haphazardly arranged networks were linked to the ultra-high-risk phenotype.Conclusions:We demonstrate that quantification of tumour stroma components by morphometric techniques has the potential to improve risk stratification of neuroblastoma patients.</p>},
  author       = {Tadeo, Irene and Berbegall, Ana P. and Castel, Victoria and García-Miguel, Purificación and Callaghan, Robert and Påhlman, Sven and Navarro, Samuel and Noguera, Rosa},
  issn         = {0007-0920},
  language     = {eng},
  month        = {08},
  number       = {4},
  pages        = {480--489},
  publisher    = {Nature Publishing Group},
  series       = {British Journal of Cancer},
  title        = {Extracellular matrix composition defines an ultra-high-risk group of neuroblastoma within the high-risk patient cohort},
  url          = {http://dx.doi.org/10.1038/bjc.2016.210},
  volume       = {115},
  year         = {2016},
}