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Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin's lymphoma

Frampton, Matthew; da Silva Filho, Miguel Inacio; Broderick, Peter; Thomsen, Hauke; Försti, Asta LU ; Vijayakrishnan, Jayaram; Cooke, Rosie; Enciso-Mora, Victor; Hoffmann, Per and Noethen, Markus M., et al. (2013) In Nature Communications 4.
Abstract
In addition to HLA, recent genome-wide association studies (GWASs) of Hodgkin's lymphoma (HL) have identified susceptibility loci for HL at 2p16.1, 8q24.21 and 10p14. In this study, we perform a GWAS meta-analysis with published GWAS (totalling 1,465 cases and 6,417 controls of European background), and follow-up the most significant association signals in 2,024 cases and 1,853 controls. A combined analysis identifies new HL susceptibility loci mapping to 3p24.1 (rs3806624; P = 1.14 x 10(-12), odds ratio (OR) = 1.26) and 6q23.3 (rs7745098; P = 3.42 x 10(-9), OR = 1.21). rs3806624 localizes 5' to the EOMES (eomesodermin) gene within a p53 response element affecting p53 binding. rs7745098 maps intergenic to HBS1L and MYB, a region previously... (More)
In addition to HLA, recent genome-wide association studies (GWASs) of Hodgkin's lymphoma (HL) have identified susceptibility loci for HL at 2p16.1, 8q24.21 and 10p14. In this study, we perform a GWAS meta-analysis with published GWAS (totalling 1,465 cases and 6,417 controls of European background), and follow-up the most significant association signals in 2,024 cases and 1,853 controls. A combined analysis identifies new HL susceptibility loci mapping to 3p24.1 (rs3806624; P = 1.14 x 10(-12), odds ratio (OR) = 1.26) and 6q23.3 (rs7745098; P = 3.42 x 10(-9), OR = 1.21). rs3806624 localizes 5' to the EOMES (eomesodermin) gene within a p53 response element affecting p53 binding. rs7745098 maps intergenic to HBS1L and MYB, a region previously associated with haematopoiesis. These findings provide further insight into the genetic and biological basis of inherited susceptibility to HL. (Less)
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@article{0ae1eff7-29b8-40f8-b79d-3ca715689c99,
  abstract     = {In addition to HLA, recent genome-wide association studies (GWASs) of Hodgkin's lymphoma (HL) have identified susceptibility loci for HL at 2p16.1, 8q24.21 and 10p14. In this study, we perform a GWAS meta-analysis with published GWAS (totalling 1,465 cases and 6,417 controls of European background), and follow-up the most significant association signals in 2,024 cases and 1,853 controls. A combined analysis identifies new HL susceptibility loci mapping to 3p24.1 (rs3806624; P = 1.14 x 10(-12), odds ratio (OR) = 1.26) and 6q23.3 (rs7745098; P = 3.42 x 10(-9), OR = 1.21). rs3806624 localizes 5' to the EOMES (eomesodermin) gene within a p53 response element affecting p53 binding. rs7745098 maps intergenic to HBS1L and MYB, a region previously associated with haematopoiesis. These findings provide further insight into the genetic and biological basis of inherited susceptibility to HL.},
  articleno    = {2549},
  author       = {Frampton, Matthew and da Silva Filho, Miguel Inacio and Broderick, Peter and Thomsen, Hauke and Försti, Asta and Vijayakrishnan, Jayaram and Cooke, Rosie and Enciso-Mora, Victor and Hoffmann, Per and Noethen, Markus M. and Lloyd, Amy and Holroyd, Amy and Eisele, Lewin and Joeckel, Karl-Heinz and Ponader, Sabine and von Strandmann, Elke Pogge and Lightfoot, Tracy and Roman, Eve and Lake, Annette and Montgomery, Dorothy and Jarrett, Ruth F. and Swerdlow, Anthony J. and Engert, Andreas and Hemminki, Kari and Houlston, Richard S.},
  issn         = {2041-1723},
  language     = {eng},
  publisher    = {Nature Publishing Group},
  series       = {Nature Communications},
  title        = {Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin's lymphoma},
  url          = {http://dx.doi.org/10.1038/ncomms3549},
  volume       = {4},
  year         = {2013},
}