Serum Glycine Levels Are Associated with Cortical Bone Properties and Fracture Risk in Men
(2021) In Journal of Clinical Endocrinology and Metabolism 106(12). p.5021-5029- Abstract
Context: In a recent study a pattern of 27 metabolites, including serum glycine, associated with bone mineral density (BMD). Objective: To investigate associations for serum and urinary glycine levels with BMD, bone microstructure, and fracture risk in men. Methods: In the population-based Osteoporotic Fractures in Men (MrOS) Sweden study (men, 69-81 years) serum glycine and BMD were measured at baseline (n†=†965) and 5-year follow-up (n†=†546). Cortical and trabecular bone parameters of the distal tibia were measured at follow-up using high-resolution peripheral quantitative computed tomography. Urinary (n†=†2682) glycine was analyzed at baseline. X-ray-validated fractures (n†=†594) were ascertained during a median... (More)
Context: In a recent study a pattern of 27 metabolites, including serum glycine, associated with bone mineral density (BMD). Objective: To investigate associations for serum and urinary glycine levels with BMD, bone microstructure, and fracture risk in men. Methods: In the population-based Osteoporotic Fractures in Men (MrOS) Sweden study (men, 69-81 years) serum glycine and BMD were measured at baseline (n†=†965) and 5-year follow-up (n†=†546). Cortical and trabecular bone parameters of the distal tibia were measured at follow-up using high-resolution peripheral quantitative computed tomography. Urinary (n†=†2682) glycine was analyzed at baseline. X-ray-validated fractures (n†=†594) were ascertained during a median follow-up of 9.6 years. Associations were evaluated using linear regression (bone parameters) or Cox regression (fractures). Results: Circulating glycine levels were inversely associated with femoral neck (FN)-BMD. A meta-analysis (n†=†7543) combining MrOS Sweden data with data from 3 other cohorts confirmed a robust inverse association between serum glycine levels and FN-BMD (P†=†7.7†×†10-9). Serum glycine was inversely associated with the bone strength parameter failure load in the distal tibia (P†=†0.002), mainly as a consequence of an inverse association with cortical cross-sectional area and a direct association with cortical porosity. Both serum and urinary glycine levels predicted major osteoporotic fractures (serum: hazard ratio [HR] per SD increase†=†1.22, 95% CI, 1.05-1.43; urine: HR†=†1.13, 95% CI, 1.02-1.24). These fracture associations were only marginally reduced in models adjusted by FRAX with BMD. Conclusions: Serum and urinary glycine are indirectly associated with FN-BMD and cortical bone strength, and directly associated with fracture risk in men.
(Less)
- author
- Eriksson, Anna L. ; Friedrich, Nele ; Karlsson, Magnus K. LU ; Ljunggren, Östen ; Lorentzon, Mattias ; Nethander, Maria ; Wallaschofski, Henri ; Mellström, Dan and Ohlsson, Claes
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- BMD, fracture, glycine, HR-pQCT, men
- in
- Journal of Clinical Endocrinology and Metabolism
- volume
- 106
- issue
- 12
- pages
- 5021 - 5029
- publisher
- Oxford University Press
- external identifiers
-
- scopus:85121235206
- pmid:34297085
- ISSN
- 0021-972X
- DOI
- 10.1210/clinem/dgab544
- language
- English
- LU publication?
- yes
- id
- 0ae7d28b-91a7-4a7e-bc05-d2cc74c83bc9
- date added to LUP
- 2022-01-27 11:58:08
- date last changed
- 2024-12-15 20:15:47
@article{0ae7d28b-91a7-4a7e-bc05-d2cc74c83bc9,
abstract = {{<p>Context: In a recent study a pattern of 27 metabolites, including serum glycine, associated with bone mineral density (BMD). Objective: To investigate associations for serum and urinary glycine levels with BMD, bone microstructure, and fracture risk in men. Methods: In the population-based Osteoporotic Fractures in Men (MrOS) Sweden study (men, 69-81 years) serum glycine and BMD were measured at baseline (n†=†965) and 5-year follow-up (n†=†546). Cortical and trabecular bone parameters of the distal tibia were measured at follow-up using high-resolution peripheral quantitative computed tomography. Urinary (n†=†2682) glycine was analyzed at baseline. X-ray-validated fractures (n†=†594) were ascertained during a median follow-up of 9.6 years. Associations were evaluated using linear regression (bone parameters) or Cox regression (fractures). Results: Circulating glycine levels were inversely associated with femoral neck (FN)-BMD. A meta-analysis (n†=†7543) combining MrOS Sweden data with data from 3 other cohorts confirmed a robust inverse association between serum glycine levels and FN-BMD (P†=†7.7†×†10-9). Serum glycine was inversely associated with the bone strength parameter failure load in the distal tibia (P†=†0.002), mainly as a consequence of an inverse association with cortical cross-sectional area and a direct association with cortical porosity. Both serum and urinary glycine levels predicted major osteoporotic fractures (serum: hazard ratio [HR] per SD increase†=†1.22, 95% CI, 1.05-1.43; urine: HR†=†1.13, 95% CI, 1.02-1.24). These fracture associations were only marginally reduced in models adjusted by FRAX with BMD. Conclusions: Serum and urinary glycine are indirectly associated with FN-BMD and cortical bone strength, and directly associated with fracture risk in men. </p>}},
author = {{Eriksson, Anna L. and Friedrich, Nele and Karlsson, Magnus K. and Ljunggren, Östen and Lorentzon, Mattias and Nethander, Maria and Wallaschofski, Henri and Mellström, Dan and Ohlsson, Claes}},
issn = {{0021-972X}},
keywords = {{BMD; fracture; glycine; HR-pQCT; men}},
language = {{eng}},
number = {{12}},
pages = {{5021--5029}},
publisher = {{Oxford University Press}},
series = {{Journal of Clinical Endocrinology and Metabolism}},
title = {{Serum Glycine Levels Are Associated with Cortical Bone Properties and Fracture Risk in Men}},
url = {{http://dx.doi.org/10.1210/clinem/dgab544}},
doi = {{10.1210/clinem/dgab544}},
volume = {{106}},
year = {{2021}},
}