A case report of a chronic migraine patient treated with three different anti-CGRP monoclonal antibodies : which parameters better represent the efficacy?
Uzun, Sena LU ; Frejvall, Ulf ; Özkaya-Sahin, Gülsen LU and Sahin, Gürdal LU
(2023)
In Frontiers in Neurology
14.
- Abstract
Objective: To report the efficacy of different anti-calcitonin gene-related peptide (CGRP) monoclonal antibodies (mAbs) on headache frequency, intensity, and duration. Background: Blockade of CGRP receptors or neuropeptide with anti-CGRP mAbs have been successfully used for several years for the prevention of chronic and episodic migraine. The response is usually assessed by improvement seen in the number of days with headache per month. However, clinical praxis indicates that sole reliance on the frequency of headaches might be insufficient to interpret the efficacy of these treatments. Methods: Retrospective review of a case with a meticulous headache diary who has tried three different anti-CGRP mAbs for chronic migraine prevention.... (More)
Objective: To report the efficacy of different anti-calcitonin gene-related peptide (CGRP) monoclonal antibodies (mAbs) on headache frequency, intensity, and duration. Background: Blockade of CGRP receptors or neuropeptide with anti-CGRP mAbs have been successfully used for several years for the prevention of chronic and episodic migraine. The response is usually assessed by improvement seen in the number of days with headache per month. However, clinical praxis indicates that sole reliance on the frequency of headaches might be insufficient to interpret the efficacy of these treatments. Methods: Retrospective review of a case with a meticulous headache diary who has tried three different anti-CGRP mAbs for chronic migraine prevention. Results: The patient has been diagnosed with chronic migraine and was first treated with erenumab, followed by fremanezumab and thereafter galcanezumab due to several reasons. In addition to significant improvement in all three parameters analyzed with anti-CGRP mAb treatment, the most important and valuable effect on the patient's quality of life was decreased duration and frequency of headaches. At present, the patient is receiving fremanezumab treatment with an excellent tolerability. Conclusion: There is a clear need for careful follow-up and detailed daily records of headaches showing the frequency, duration, and severity for the evaluation of anti-CGRP mAbs treatment. This study shows the importance of this information in order for medical professionals to make an informed decision regarding the best course of anti-CGRP mAbs treatment in cases of side effects or lack of efficacy.
(Less)
- author
- Uzun, Sena
LU
; Frejvall, Ulf
; Özkaya-Sahin, Gülsen
LU
and Sahin, Gürdal
LU
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- anti-CGRP monoclonal antibodies, case report, chronic migraine, erenumab, fremanezumab, galcanezumab
- in
- Frontiers in Neurology
- volume
- 14
- article number
- 1176816
- publisher
- Frontiers Media S. A.
- external identifiers
-
- pmid:37213912
- scopus:85159920084
- ISSN
- 1664-2295
- DOI
- 10.3389/fneur.2023.1176816
- language
- English
- LU publication?
- yes
- id
- 0b156669-3ffe-4933-b451-4f3819d7c730
- date added to LUP
- 2023-09-18 12:49:24
- date last changed
- 2024-04-19 01:15:47
@article{0b156669-3ffe-4933-b451-4f3819d7c730,
abstract = {{<p>Objective: To report the efficacy of different anti-calcitonin gene-related peptide (CGRP) monoclonal antibodies (mAbs) on headache frequency, intensity, and duration. Background: Blockade of CGRP receptors or neuropeptide with anti-CGRP mAbs have been successfully used for several years for the prevention of chronic and episodic migraine. The response is usually assessed by improvement seen in the number of days with headache per month. However, clinical praxis indicates that sole reliance on the frequency of headaches might be insufficient to interpret the efficacy of these treatments. Methods: Retrospective review of a case with a meticulous headache diary who has tried three different anti-CGRP mAbs for chronic migraine prevention. Results: The patient has been diagnosed with chronic migraine and was first treated with erenumab, followed by fremanezumab and thereafter galcanezumab due to several reasons. In addition to significant improvement in all three parameters analyzed with anti-CGRP mAb treatment, the most important and valuable effect on the patient's quality of life was decreased duration and frequency of headaches. At present, the patient is receiving fremanezumab treatment with an excellent tolerability. Conclusion: There is a clear need for careful follow-up and detailed daily records of headaches showing the frequency, duration, and severity for the evaluation of anti-CGRP mAbs treatment. This study shows the importance of this information in order for medical professionals to make an informed decision regarding the best course of anti-CGRP mAbs treatment in cases of side effects or lack of efficacy.</p>}},
author = {{Uzun, Sena and Frejvall, Ulf and Özkaya-Sahin, Gülsen and Sahin, Gürdal}},
issn = {{1664-2295}},
keywords = {{anti-CGRP monoclonal antibodies; case report; chronic migraine; erenumab; fremanezumab; galcanezumab}},
language = {{eng}},
publisher = {{Frontiers Media S. A.}},
series = {{Frontiers in Neurology}},
title = {{A case report of a chronic migraine patient treated with three different anti-CGRP monoclonal antibodies : which parameters better represent the efficacy?}},
url = {{http://dx.doi.org/10.3389/fneur.2023.1176816}},
doi = {{10.3389/fneur.2023.1176816}},
volume = {{14}},
year = {{2023}},
}