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A meroterpenoid NF-kappa B inhibitor and drimane sesquiterpenoids from asafetida

Appendino, Giovanni ; Maxia, Lucia ; Bascope, Marcelo LU ; Houghton, Peter J. ; Sanchez-Duffhues, Gonzalo ; Munoz, Eduardo and Sterner, Olov LU (2006) In Journal of Natural Products 69(7). p.1101-1104
Abstract
Investigation of an acetone extract from asafetida afforded two drimane sesquiterpene dienones (fetidones A and B, 1a,b) and several known sesquiterpene coumarin ethers, one of which (8-acetoxy-5-hydroxyumbelliprenin, 2a) showed potent and specific NF-kappa B-inhibiting properties. This, coupled to a negligible cytotoxicity, qualifies 2a as a new anti-inflammatory chemotype, and its occurrence in asafetida might rationalize the use of this gum resin to alleviate and prevent colon inflammatory disturbances.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Natural Products
volume
69
issue
7
pages
1101 - 1104
publisher
The American Chemical Society (ACS)
external identifiers
  • pmid:16872156
  • wos:000239336000028
  • scopus:33747421726
  • pmid:16872156
ISSN
0163-3864
DOI
10.1021/np0600954
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
id
0b2c1138-0d7a-42e4-975e-dc60c199adab (old id 399493)
date added to LUP
2016-04-01 16:07:07
date last changed
2020-01-12 19:03:11
@article{0b2c1138-0d7a-42e4-975e-dc60c199adab,
  abstract     = {Investigation of an acetone extract from asafetida afforded two drimane sesquiterpene dienones (fetidones A and B, 1a,b) and several known sesquiterpene coumarin ethers, one of which (8-acetoxy-5-hydroxyumbelliprenin, 2a) showed potent and specific NF-kappa B-inhibiting properties. This, coupled to a negligible cytotoxicity, qualifies 2a as a new anti-inflammatory chemotype, and its occurrence in asafetida might rationalize the use of this gum resin to alleviate and prevent colon inflammatory disturbances.},
  author       = {Appendino, Giovanni and Maxia, Lucia and Bascope, Marcelo and Houghton, Peter J. and Sanchez-Duffhues, Gonzalo and Munoz, Eduardo and Sterner, Olov},
  issn         = {0163-3864},
  language     = {eng},
  number       = {7},
  pages        = {1101--1104},
  publisher    = {The American Chemical Society (ACS)},
  series       = {Journal of Natural Products},
  title        = {A meroterpenoid NF-kappa B inhibitor and drimane sesquiterpenoids from asafetida},
  url          = {http://dx.doi.org/10.1021/np0600954},
  doi          = {10.1021/np0600954},
  volume       = {69},
  year         = {2006},
}