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A meroterpenoid NF-kappa B inhibitor and drimane sesquiterpenoids from asafetida

Appendino, Giovanni ; Maxia, Lucia ; Bascope, Marcelo LU ; Houghton, Peter J. ; Sanchez-Duffhues, Gonzalo ; Munoz, Eduardo and Sterner, Olov LU (2006) In Journal of Natural Products 69(7). p.1101-1104
Abstract
Investigation of an acetone extract from asafetida afforded two drimane sesquiterpene dienones (fetidones A and B, 1a,b) and several known sesquiterpene coumarin ethers, one of which (8-acetoxy-5-hydroxyumbelliprenin, 2a) showed potent and specific NF-kappa B-inhibiting properties. This, coupled to a negligible cytotoxicity, qualifies 2a as a new anti-inflammatory chemotype, and its occurrence in asafetida might rationalize the use of this gum resin to alleviate and prevent colon inflammatory disturbances.
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Natural Products
volume
69
issue
7
pages
1101 - 1104
publisher
The American Chemical Society (ACS)
external identifiers
  • pmid:16872156
  • wos:000239336000028
  • scopus:33747421726
  • pmid:16872156
ISSN
0163-3864
DOI
10.1021/np0600954
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
id
0b2c1138-0d7a-42e4-975e-dc60c199adab (old id 399493)
date added to LUP
2016-04-01 16:07:07
date last changed
2022-02-20 03:23:16
@article{0b2c1138-0d7a-42e4-975e-dc60c199adab,
  abstract     = {{Investigation of an acetone extract from asafetida afforded two drimane sesquiterpene dienones (fetidones A and B, 1a,b) and several known sesquiterpene coumarin ethers, one of which (8-acetoxy-5-hydroxyumbelliprenin, 2a) showed potent and specific NF-kappa B-inhibiting properties. This, coupled to a negligible cytotoxicity, qualifies 2a as a new anti-inflammatory chemotype, and its occurrence in asafetida might rationalize the use of this gum resin to alleviate and prevent colon inflammatory disturbances.}},
  author       = {{Appendino, Giovanni and Maxia, Lucia and Bascope, Marcelo and Houghton, Peter J. and Sanchez-Duffhues, Gonzalo and Munoz, Eduardo and Sterner, Olov}},
  issn         = {{0163-3864}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{1101--1104}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{Journal of Natural Products}},
  title        = {{A meroterpenoid NF-kappa B inhibitor and drimane sesquiterpenoids from asafetida}},
  url          = {{http://dx.doi.org/10.1021/np0600954}},
  doi          = {{10.1021/np0600954}},
  volume       = {{69}},
  year         = {{2006}},
}