Glycemic control and outcome after carotid intervention in patients with T2D : A Swedish nationwide cohort study
(2023) In Diabetes & Vascular Disease Research 20(3).- Abstract
AIMS: To investigate the association between glycemic control and outcome in people with type 2 diabetes (T2D) after carotid intervention due to carotid stenosis.
METHODS: Observational nationwide population-based cohort study using inverse probability treatment weighting (IPTW) and Cox regressions with covariates, that is, 4 stepwise models, investigating the relationship between terciles of glycated hemoglobin (HbA1c) levels and stroke or death.
RESULTS: 1115 subjects with T2D undergoing carotid intervention were included during Jan 1st 2009 to Dec 31st 2015. Divided into terciles, with a mean HbA1c level of 44 (tercile 1), 53 (tercile 2), and 72 (tercile 3) mmol/mol. By using IPTW and Cox regression, each model was... (More)
AIMS: To investigate the association between glycemic control and outcome in people with type 2 diabetes (T2D) after carotid intervention due to carotid stenosis.
METHODS: Observational nationwide population-based cohort study using inverse probability treatment weighting (IPTW) and Cox regressions with covariates, that is, 4 stepwise models, investigating the relationship between terciles of glycated hemoglobin (HbA1c) levels and stroke or death.
RESULTS: 1115 subjects with T2D undergoing carotid intervention were included during Jan 1st 2009 to Dec 31st 2015. Divided into terciles, with a mean HbA1c level of 44 (tercile 1), 53 (tercile 2), and 72 (tercile 3) mmol/mol. By using IPTW and Cox regression, each model was stepwise introduced for the investigating of relative risks, that is, hazard ratios (HRs) with associated 95% confidence intervals (CI). There was a significant increased risk for stroke or death, in every model observed for tercile 3, compared to tercile 1: HR for model 4: 1.35 (95% CI 1.02-1.78). No difference for stroke or death within 30 days was observed between the groups.
CONCLUSION: Poor glycemic control in people with T2D after carotid intervention is associated with an increased long-term risk for stroke or death.
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- author
- Zabala, Alexander ; Gottsäter, Anders LU ; Lind, Marcus ; Eliasson, Björn ; Bertilsson, Rebecka ; Ekelund, Jan ; Jonsson, Magnus and Nyström, Thomas
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Humans, Cohort Studies, Endarterectomy, Carotid/adverse effects, Diabetes Mellitus, Type 2/complications, Glycated Hemoglobin, Glycemic Control/adverse effects, Sweden/epidemiology, Treatment Outcome, Carotid Stenosis/diagnostic imaging, Stroke/diagnosis, Risk Factors
- in
- Diabetes & Vascular Disease Research
- volume
- 20
- issue
- 3
- publisher
- SAGE Publications
- external identifiers
-
- scopus:85163922905
- pmid:37340709
- ISSN
- 1752-8984
- DOI
- 10.1177/14791641231176767
- language
- English
- LU publication?
- yes
- id
- 0b5cde9c-78c3-475c-a7a3-ea4e8d5ab57f
- date added to LUP
- 2023-08-31 09:05:38
- date last changed
- 2024-04-20 02:16:49
@article{0b5cde9c-78c3-475c-a7a3-ea4e8d5ab57f,
abstract = {{<p>AIMS: To investigate the association between glycemic control and outcome in people with type 2 diabetes (T2D) after carotid intervention due to carotid stenosis.</p><p>METHODS: Observational nationwide population-based cohort study using inverse probability treatment weighting (IPTW) and Cox regressions with covariates, that is, 4 stepwise models, investigating the relationship between terciles of glycated hemoglobin (HbA1c) levels and stroke or death.</p><p>RESULTS: 1115 subjects with T2D undergoing carotid intervention were included during Jan 1st 2009 to Dec 31st 2015. Divided into terciles, with a mean HbA1c level of 44 (tercile 1), 53 (tercile 2), and 72 (tercile 3) mmol/mol. By using IPTW and Cox regression, each model was stepwise introduced for the investigating of relative risks, that is, hazard ratios (HRs) with associated 95% confidence intervals (CI). There was a significant increased risk for stroke or death, in every model observed for tercile 3, compared to tercile 1: HR for model 4: 1.35 (95% CI 1.02-1.78). No difference for stroke or death within 30 days was observed between the groups.</p><p>CONCLUSION: Poor glycemic control in people with T2D after carotid intervention is associated with an increased long-term risk for stroke or death.</p>}},
author = {{Zabala, Alexander and Gottsäter, Anders and Lind, Marcus and Eliasson, Björn and Bertilsson, Rebecka and Ekelund, Jan and Jonsson, Magnus and Nyström, Thomas}},
issn = {{1752-8984}},
keywords = {{Humans; Cohort Studies; Endarterectomy, Carotid/adverse effects; Diabetes Mellitus, Type 2/complications; Glycated Hemoglobin; Glycemic Control/adverse effects; Sweden/epidemiology; Treatment Outcome; Carotid Stenosis/diagnostic imaging; Stroke/diagnosis; Risk Factors}},
language = {{eng}},
number = {{3}},
publisher = {{SAGE Publications}},
series = {{Diabetes & Vascular Disease Research}},
title = {{Glycemic control and outcome after carotid intervention in patients with T2D : A Swedish nationwide cohort study}},
url = {{http://dx.doi.org/10.1177/14791641231176767}},
doi = {{10.1177/14791641231176767}},
volume = {{20}},
year = {{2023}},
}