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Double lung, unlike single lung transplantation might provide a protective effect on mortality and bronchiolitis obliterans syndrome

Fakhro, Mohammed LU ; Broberg, Ellen LU ; Algotsson, Lars LU ; Hansson, Lennart LU ; Koul, Bansi LU ; Gustafsson, Ronny LU ; Wierup, Per LU ; Ingemansson, Richard LU and Lindstedt, Sandra LU (2017) In Journal of Cardiothoracic Surgery 12(1).
Abstract

BACKGROUND: Survival after lung transplantation (LTx) is often limited by bronchiolitis obliterans syndrome (BOS).

METHOD: Survey of 278 recipients who underwent LTx. The endpoint used was BOS (BOS grade ≥ 2), death or Re-lung transplantation (Re-LTx) assessed by competing risk regression analyses.

RESULTS: The incidence of BOS grade ≥ 2 among double LTx (DLTx) recipients was 16 ± 3% at 5 years, 30 ± 4% at 10 years, and 37 ± 5% at 20 years, compared to single LTx (SLTx) recipients whose corresponding incidence of BOS grade ≥ 2 was 11 ± 3%, 20 ± 4%, and 24 ± 5% at 5, 10, and 20 years, respectively (p > 0. 05). The incidence of BOS grade ≥ 2 by major indications ranked in descending order: other, PF, CF, COPD, PH and AAT1... (More)

BACKGROUND: Survival after lung transplantation (LTx) is often limited by bronchiolitis obliterans syndrome (BOS).

METHOD: Survey of 278 recipients who underwent LTx. The endpoint used was BOS (BOS grade ≥ 2), death or Re-lung transplantation (Re-LTx) assessed by competing risk regression analyses.

RESULTS: The incidence of BOS grade ≥ 2 among double LTx (DLTx) recipients was 16 ± 3% at 5 years, 30 ± 4% at 10 years, and 37 ± 5% at 20 years, compared to single LTx (SLTx) recipients whose corresponding incidence of BOS grade ≥ 2 was 11 ± 3%, 20 ± 4%, and 24 ± 5% at 5, 10, and 20 years, respectively (p > 0. 05). The incidence of BOS grade ≥ 2 by major indications ranked in descending order: other, PF, CF, COPD, PH and AAT1 (p < 0. 05). The mortality rate by major indication ranked in descending order: COPD, PH, AAT1, PF, Other and CF (p < 0. 05).

CONCLUSION: No differences were seen in the incidence of BOS grade ≥ 2 regarding type of transplant, however, DLTx recipients showed a better chance of survival despite developing BOS compared to SLTx recipients. The highest incidence of BOS was seen among CF, PF, COPD, PH, and AAT1 recipients in descending order, however, CF and PF recipients showed a better chance of survival despite developing BOS compared to COPD, PH, and AAT1 recipients.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Cardiothoracic Surgery
volume
12
issue
1
article number
100
publisher
BioMed Central (BMC)
external identifiers
  • scopus:85034816455
  • wos:000416124100002
  • pmid:29178919
ISSN
1749-8090
DOI
10.1186/s13019-017-0666-5
language
English
LU publication?
yes
id
0bb1d1ba-cd4d-4df8-955a-3b8fb3eaa894
date added to LUP
2017-11-28 20:57:17
date last changed
2025-01-08 01:43:43
@article{0bb1d1ba-cd4d-4df8-955a-3b8fb3eaa894,
  abstract     = {{<p>BACKGROUND: Survival after lung transplantation (LTx) is often limited by bronchiolitis obliterans syndrome (BOS).</p><p>METHOD: Survey of 278 recipients who underwent LTx. The endpoint used was BOS (BOS grade ≥ 2), death or Re-lung transplantation (Re-LTx) assessed by competing risk regression analyses.</p><p>RESULTS: The incidence of BOS grade ≥ 2 among double LTx (DLTx) recipients was 16 ± 3% at 5 years, 30 ± 4% at 10 years, and 37 ± 5% at 20 years, compared to single LTx (SLTx) recipients whose corresponding incidence of BOS grade ≥ 2 was 11 ± 3%, 20 ± 4%, and 24 ± 5% at 5, 10, and 20 years, respectively (p &gt; 0. 05). The incidence of BOS grade ≥ 2 by major indications ranked in descending order: other, PF, CF, COPD, PH and AAT1 (p &lt; 0. 05). The mortality rate by major indication ranked in descending order: COPD, PH, AAT1, PF, Other and CF (p &lt; 0. 05).</p><p>CONCLUSION: No differences were seen in the incidence of BOS grade ≥ 2 regarding type of transplant, however, DLTx recipients showed a better chance of survival despite developing BOS compared to SLTx recipients. The highest incidence of BOS was seen among CF, PF, COPD, PH, and AAT1 recipients in descending order, however, CF and PF recipients showed a better chance of survival despite developing BOS compared to COPD, PH, and AAT1 recipients.</p>}},
  author       = {{Fakhro, Mohammed and Broberg, Ellen and Algotsson, Lars and Hansson, Lennart and Koul, Bansi and Gustafsson, Ronny and Wierup, Per and Ingemansson, Richard and Lindstedt, Sandra}},
  issn         = {{1749-8090}},
  language     = {{eng}},
  month        = {{11}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Journal of Cardiothoracic Surgery}},
  title        = {{Double lung, unlike single lung transplantation might provide a protective effect on mortality and bronchiolitis obliterans syndrome}},
  url          = {{http://dx.doi.org/10.1186/s13019-017-0666-5}},
  doi          = {{10.1186/s13019-017-0666-5}},
  volume       = {{12}},
  year         = {{2017}},
}