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Comparative evaluation of simple insulin sensitivity methods based on the oral glucose tolerance test

Mari, A ; Pacini, G ; Brazzale, A R and Ahrén, Bo LU (2005) In Diabetologia 48(4). p.748-751
Abstract
Aims/hypothesis: We compared five surrogate insulin sensitivity ( IS) methods against the euglycaemic - hyperinsulinaemic clamp. These methods were the homeostasis model assessment (HOMA) and four methods based on the OGTT (OGIS, MCRest, ISIcomp, SIORAL). Methods: We compared these IS methods against the clamp (0.28 nmol center dot min(-1) center dot m(-2) insulin infusion) M value in 147 women ( 58 - 61 years; BMI 19 - 38 kg/m(2); 116 NGT, 25 IFG/IGT, six type 2 diabetic), by evaluating the correlation coefficient with M. We also tested the ability to reproduce the relationships between IS and typical IS correlates ( BMI, fasting insulin, insulin to glucose OGTT area ratio and fasting, 2 h and mean glucose) by means of the "discrepancy... (More)
Aims/hypothesis: We compared five surrogate insulin sensitivity ( IS) methods against the euglycaemic - hyperinsulinaemic clamp. These methods were the homeostasis model assessment (HOMA) and four methods based on the OGTT (OGIS, MCRest, ISIcomp, SIORAL). Methods: We compared these IS methods against the clamp (0.28 nmol center dot min(-1) center dot m(-2) insulin infusion) M value in 147 women ( 58 - 61 years; BMI 19 - 38 kg/m(2); 116 NGT, 25 IFG/IGT, six type 2 diabetic), by evaluating the correlation coefficient with M. We also tested the ability to reproduce the relationships between IS and typical IS correlates ( BMI, fasting insulin, insulin to glucose OGTT area ratio and fasting, 2 h and mean glucose) by means of the "discrepancy index" D, in which ( 1) D=0 if the correlation between IS and the variable of interest is as with the clamp, ( 2) D is smaller than 0 if the correlation is overestimated, and ( 3) D is greater than 0 if underestimated. Results: All IS methods correlated with M ( r=0.57 - 0.83, p< 0.0001); for MCRest the relationship was markedly curvilinear. All IS measures correlated with the considered variables (r= 0.29 - 0.94, p< 0.0005); however, no method had D approximate to 0 for all variables. The best surrogates of M were OGIS ( one D. 0) and MCRest ( two D. 0); the other methods either under- or overestimated the degree of correlation three or more D. 0), in particular with fasting insulin (HOMA: D=- 57%; ISIcomp: D=- 36%) and BMI ( HOMA: D=- 14%; ISIcomp: D=- 14%; SiORAL: D=- 11%). Conclusions/interpretation: AllIS methods were correlated with M. OGIS and MCRest were preferable to the other methods and in particular to HOMA for reproducing relationships with the independent variables. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
insulin sensitivity, glucose clamp, glucose tolerance, OGTT
in
Diabetologia
volume
48
issue
4
pages
748 - 751
publisher
Springer
external identifiers
  • pmid:15744532
  • wos:000228515900021
  • scopus:17844407717
ISSN
1432-0428
DOI
10.1007/s00125-005-1683-9
language
English
LU publication?
yes
id
0bec706f-91d0-4fba-9b01-b252dc6dc8bb (old id 245820)
date added to LUP
2016-04-01 12:13:13
date last changed
2024-01-23 10:27:30
@article{0bec706f-91d0-4fba-9b01-b252dc6dc8bb,
  abstract     = {{Aims/hypothesis: We compared five surrogate insulin sensitivity ( IS) methods against the euglycaemic - hyperinsulinaemic clamp. These methods were the homeostasis model assessment (HOMA) and four methods based on the OGTT (OGIS, MCRest, ISIcomp, SIORAL). Methods: We compared these IS methods against the clamp (0.28 nmol center dot min(-1) center dot m(-2) insulin infusion) M value in 147 women ( 58 - 61 years; BMI 19 - 38 kg/m(2); 116 NGT, 25 IFG/IGT, six type 2 diabetic), by evaluating the correlation coefficient with M. We also tested the ability to reproduce the relationships between IS and typical IS correlates ( BMI, fasting insulin, insulin to glucose OGTT area ratio and fasting, 2 h and mean glucose) by means of the "discrepancy index" D, in which ( 1) D=0 if the correlation between IS and the variable of interest is as with the clamp, ( 2) D is smaller than 0 if the correlation is overestimated, and ( 3) D is greater than 0 if underestimated. Results: All IS methods correlated with M ( r=0.57 - 0.83, p&lt; 0.0001); for MCRest the relationship was markedly curvilinear. All IS measures correlated with the considered variables (r= 0.29 - 0.94, p&lt; 0.0005); however, no method had D approximate to 0 for all variables. The best surrogates of M were OGIS ( one D. 0) and MCRest ( two D. 0); the other methods either under- or overestimated the degree of correlation three or more D. 0), in particular with fasting insulin (HOMA: D=- 57%; ISIcomp: D=- 36%) and BMI ( HOMA: D=- 14%; ISIcomp: D=- 14%; SiORAL: D=- 11%). Conclusions/interpretation: AllIS methods were correlated with M. OGIS and MCRest were preferable to the other methods and in particular to HOMA for reproducing relationships with the independent variables.}},
  author       = {{Mari, A and Pacini, G and Brazzale, A R and Ahrén, Bo}},
  issn         = {{1432-0428}},
  keywords     = {{insulin sensitivity; glucose clamp; glucose tolerance; OGTT}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{748--751}},
  publisher    = {{Springer}},
  series       = {{Diabetologia}},
  title        = {{Comparative evaluation of simple insulin sensitivity methods based on the oral glucose tolerance test}},
  url          = {{http://dx.doi.org/10.1007/s00125-005-1683-9}},
  doi          = {{10.1007/s00125-005-1683-9}},
  volume       = {{48}},
  year         = {{2005}},
}