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Integration of acousto- and dielectrophoresis allows tumor cell separation and enrichment followed by arraying of target cells toward analysis of circulating tumor cells at the single-cell level

Kim, S. H.; Antfolk, M. LU ; Jonsson, L. LU ; Saori, K.; Kaneda, S.; Fujii, T. and Laurell, T. LU (2015) 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 In MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences p.346-348
Abstract

We present an advanced approach for single-cell analysis of circulating tumor cells (CTCs) by integrating an acoustofluidic chip for sample preparation, including simultaneous acoustophoretic separation and enrichment of the separated cells, onto an electroactive microwell array (EMA) for single-cell arraying. The integrated device shows highly efficient cell recovery of target cells (82.5%) and depletion of non-target cells (92.8%).

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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Acoustophoresis, Circulating tumor cells, Dielectrophoresis
in
MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
pages
3 pages
publisher
Chemical and Biological Microsystems Society
conference name
19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
external identifiers
  • scopus:84983365292
ISBN
9780979806483
language
English
LU publication?
yes
id
0bf64039-3127-4988-ae84-ad43aedcacbd
date added to LUP
2016-12-14 09:02:28
date last changed
2017-01-01 08:43:19
@inproceedings{0bf64039-3127-4988-ae84-ad43aedcacbd,
  abstract     = {<p>We present an advanced approach for single-cell analysis of circulating tumor cells (CTCs) by integrating an acoustofluidic chip for sample preparation, including simultaneous acoustophoretic separation and enrichment of the separated cells, onto an electroactive microwell array (EMA) for single-cell arraying. The integrated device shows highly efficient cell recovery of target cells (82.5%) and depletion of non-target cells (92.8%).</p>},
  author       = {Kim, S. H. and Antfolk, M. and Jonsson, L. and Saori, K. and Kaneda, S. and Fujii, T. and Laurell, T.},
  booktitle    = {MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences},
  isbn         = {9780979806483},
  keyword      = {Acoustophoresis,Circulating tumor cells,Dielectrophoresis},
  language     = {eng},
  pages        = {346--348},
  publisher    = {Chemical and Biological Microsystems Society},
  title        = {Integration of acousto- and dielectrophoresis allows tumor cell separation and enrichment followed by arraying of target cells toward analysis of circulating tumor cells at the single-cell level},
  year         = {2015},
}