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MicroRNAs as cancer therapeutics : A step closer to clinical application

Catela Ivkovic, Tina LU ; Voss, Gjendine LU ; Cornella, Helena LU and Ceder, Yvonne LU (2017) In Cancer Letters
Abstract

During the last decades, basic and translational research has enabled great improvements in the clinical management of cancer. However, scarcity of complete remission and many drug-induced toxicities are still a major problem in the clinics. Recently, microRNAs (miRNAs) have emerged as promising therapeutic targets due to their involvement in cancer development and progression. Their extraordinary regulatory potential, which enables regulation of entire signalling networks within the cells, makes them an interesting tool for the development of cancer therapeutics. In this review we will focus on miRNAs with experimentally proven therapeutic potential, and discuss recent advances in the technical development and clinical evaluation of... (More)

During the last decades, basic and translational research has enabled great improvements in the clinical management of cancer. However, scarcity of complete remission and many drug-induced toxicities are still a major problem in the clinics. Recently, microRNAs (miRNAs) have emerged as promising therapeutic targets due to their involvement in cancer development and progression. Their extraordinary regulatory potential, which enables regulation of entire signalling networks within the cells, makes them an interesting tool for the development of cancer therapeutics. In this review we will focus on miRNAs with experimentally proven therapeutic potential, and discuss recent advances in the technical development and clinical evaluation of miRNA-based therapeutic agents.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
in press
subject
keywords
Drug delivery, Metastases, MiR-15/16, MiR-155, MiR-34a, Therapy resistance
in
Cancer Letters
publisher
Elsevier
external identifiers
  • scopus:85018738027
ISSN
0304-3835
DOI
10.1016/j.canlet.2017.04.007
language
English
LU publication?
yes
id
0c6388f5-60d9-4418-8df2-371f1e8e06a6
date added to LUP
2017-06-14 15:21:55
date last changed
2017-09-03 05:23:28
@article{0c6388f5-60d9-4418-8df2-371f1e8e06a6,
  abstract     = {<p>During the last decades, basic and translational research has enabled great improvements in the clinical management of cancer. However, scarcity of complete remission and many drug-induced toxicities are still a major problem in the clinics. Recently, microRNAs (miRNAs) have emerged as promising therapeutic targets due to their involvement in cancer development and progression. Their extraordinary regulatory potential, which enables regulation of entire signalling networks within the cells, makes them an interesting tool for the development of cancer therapeutics. In this review we will focus on miRNAs with experimentally proven therapeutic potential, and discuss recent advances in the technical development and clinical evaluation of miRNA-based therapeutic agents.</p>},
  author       = {Catela Ivkovic, Tina and Voss, Gjendine and Cornella, Helena and Ceder, Yvonne},
  issn         = {0304-3835},
  keyword      = {Drug delivery,Metastases,MiR-15/16,MiR-155,MiR-34a,Therapy resistance},
  language     = {eng},
  month        = {02},
  publisher    = {Elsevier},
  series       = {Cancer Letters},
  title        = {MicroRNAs as cancer therapeutics : A step closer to clinical application},
  url          = {http://dx.doi.org/10.1016/j.canlet.2017.04.007},
  year         = {2017},
}