Prognostic factors in lung cancer in a defined geographical area over two decades with a special emphasis on gender.
Svensson, Gunnar A LU ; Ewers, Sven-Börje LU ; Ohlsson, Ola LU and Olsson, Håkan LU
(2013)
In Clinical Respiratory Journal
7(1).
p.91-100
- Abstract
- Introduction: Many studies over recent decades report an increasing incidence of lung cancer in female patients. Female gender is often reported as a good prognostic factor.
Objectives: The aim of the present study was to investigate prognostic factors with a special emphasis on gender.
Methods: During 1989-2008, 1497 patients in eastern Scania, a part of southern Sweden with 202 000 inhabitants, were referred to one Central Hospital and prospectively registered. All patients were grouped into four 5-year periods and analysed for occurrence of lung cancer, patient performance status, types and stages of lung cancer and the relation to gender.
Results: The incidence of lung cancer... (More) - Introduction: Many studies over recent decades report an increasing incidence of lung cancer in female patients. Female gender is often reported as a good prognostic factor.
Objectives: The aim of the present study was to investigate prognostic factors with a special emphasis on gender.
Methods: During 1989-2008, 1497 patients in eastern Scania, a part of southern Sweden with 202 000 inhabitants, were referred to one Central Hospital and prospectively registered. All patients were grouped into four 5-year periods and analysed for occurrence of lung cancer, patient performance status, types and stages of lung cancer and the relation to gender.
Results: The incidence of lung cancer more than doubled in women. The proportion of adenocarcinomas increased in females and males to 57 % (p=0.028) and 42 % (p=0.001), respectively, while the frequency of small cell lung carcinomas (SCLCs) decreased in both genders to approximately 14 %. Females had significantly more frequent stage 1 (16.6 %) and higher surgery rate (23.1 %) than males (12 % and 18.2 %, respectively). Females showed a higher 5-year survival rate than males (20.1 % and 11.5 %, respectively; p<0.001). Patients with non-small cell lung carcinoma (NSCLC) had a higher 5-year survival rate than those with SCLC (16.5 % and 7.5 %, respectively; p<0.01); however there was no significant survival difference in females between NSCLC and SCLC.
Conclusion: Female patients exhibited longer survival than males for both NSCLC and SCLC, and this was not explained by a higher frequency of stage 1 or surgery in NSCLC. © 2012 Blackwell Publishing Ltd. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2432368
- author
- Svensson, Gunnar A
LU
; Ewers, Sven-Börje
LU
; Ohlsson, Ola
LU
and Olsson, Håkan
LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Clinical Respiratory Journal
- volume
- 7
- issue
- 1
- pages
- 91 - 100
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000316823100014
- pmid:22380488
- scopus:84875667444
- pmid:22380488
- ISSN
- 1752-6981
- DOI
- 10.1111/j.1752-699X.2012.00289.x
- language
- English
- LU publication?
- yes
- id
- 0c686272-250e-4559-ba32-a91492b2ee5c (old id 2432368)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22380488?dopt=Abstract
- date added to LUP
- 2016-04-01 11:00:00
- date last changed
- 2024-01-07 06:20:44
@article{0c686272-250e-4559-ba32-a91492b2ee5c,
abstract = {{Introduction: Many studies over recent decades report an increasing incidence of lung cancer in female patients. Female gender is often reported as a good prognostic factor. <br/><br>
<br/><br>
Objectives: The aim of the present study was to investigate prognostic factors with a special emphasis on gender. <br/><br>
<br/><br>
Methods: During 1989-2008, 1497 patients in eastern Scania, a part of southern Sweden with 202 000 inhabitants, were referred to one Central Hospital and prospectively registered. All patients were grouped into four 5-year periods and analysed for occurrence of lung cancer, patient performance status, types and stages of lung cancer and the relation to gender. <br/><br>
<br/><br>
Results: The incidence of lung cancer more than doubled in women. The proportion of adenocarcinomas increased in females and males to 57 % (p=0.028) and 42 % (p=0.001), respectively, while the frequency of small cell lung carcinomas (SCLCs) decreased in both genders to approximately 14 %. Females had significantly more frequent stage 1 (16.6 %) and higher surgery rate (23.1 %) than males (12 % and 18.2 %, respectively). Females showed a higher 5-year survival rate than males (20.1 % and 11.5 %, respectively; p<0.001). Patients with non-small cell lung carcinoma (NSCLC) had a higher 5-year survival rate than those with SCLC (16.5 % and 7.5 %, respectively; p<0.01); however there was no significant survival difference in females between NSCLC and SCLC. <br/><br>
<br/><br>
Conclusion: Female patients exhibited longer survival than males for both NSCLC and SCLC, and this was not explained by a higher frequency of stage 1 or surgery in NSCLC. © 2012 Blackwell Publishing Ltd.}},
author = {{Svensson, Gunnar A and Ewers, Sven-Börje and Ohlsson, Ola and Olsson, Håkan}},
issn = {{1752-6981}},
language = {{eng}},
number = {{1}},
pages = {{91--100}},
publisher = {{Wiley-Blackwell}},
series = {{Clinical Respiratory Journal}},
title = {{Prognostic factors in lung cancer in a defined geographical area over two decades with a special emphasis on gender.}},
url = {{http://dx.doi.org/10.1111/j.1752-699X.2012.00289.x}},
doi = {{10.1111/j.1752-699X.2012.00289.x}},
volume = {{7}},
year = {{2013}},
}