An experimental study of gastric stump carcinoma in Wistar rats
(1995) In APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 103(12). p.878-884- Abstract
- The risk of gastric stump carcinoma is increased 15-20 years after gastric resection for benign disease. Reflux of duodenal juice, bacterial overgrowth and formation of N-nitroso compounds are possible etiological factors. There is a geographical variation in the incidence of gastric cancer, possibly explained by differences in food intake. Experimentally it is possible to induce gastric stump carcinoma in rats without the addition of exogenous carcinogens. The aim of this study was: 1) to find the incidence of gastric carcinoma in rats subjected to BII resection and followed for 10 months, and 2) to examine if acetic acid, a common dietary factor, could influence the development of gastric carcinoma. Amongst BII-operated male Wistar rats,... (More)
- The risk of gastric stump carcinoma is increased 15-20 years after gastric resection for benign disease. Reflux of duodenal juice, bacterial overgrowth and formation of N-nitroso compounds are possible etiological factors. There is a geographical variation in the incidence of gastric cancer, possibly explained by differences in food intake. Experimentally it is possible to induce gastric stump carcinoma in rats without the addition of exogenous carcinogens. The aim of this study was: 1) to find the incidence of gastric carcinoma in rats subjected to BII resection and followed for 10 months, and 2) to examine if acetic acid, a common dietary factor, could influence the development of gastric carcinoma. Amongst BII-operated male Wistar rats, infiltrating carcinoma was found in 5/20 on a normal diet and in 5/24 exposed to acetic acid (NS). Benign mucosal changes were seen in 12/20 and 16/24 respectively (NS). With the exception of a profound inflammation in one sham-operated animal, no mucosal pathological changes were found in 24 sham-operated and 24 control animals where no operation was performed. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1109767
- author
- Ehrnström, Roy LU ; Lindstrom, C G ; Arvidsson, S ; Sternby, Nils LU ; Nilsson, E and Ehrnstrom, Y M
- organization
- publishing date
- 1995
- type
- Contribution to journal
- publication status
- published
- subject
- in
- APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
- volume
- 103
- issue
- 12
- pages
- 878 - 884
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:8562028
- scopus:0029561504
- ISSN
- 1600-0463
- language
- English
- LU publication?
- yes
- id
- 0ce1fe8c-8a7a-4c45-8637-8fffaf3dd2ab (old id 1109767)
- date added to LUP
- 2016-04-01 11:45:56
- date last changed
- 2021-01-03 04:36:38
@article{0ce1fe8c-8a7a-4c45-8637-8fffaf3dd2ab,
abstract = {{The risk of gastric stump carcinoma is increased 15-20 years after gastric resection for benign disease. Reflux of duodenal juice, bacterial overgrowth and formation of N-nitroso compounds are possible etiological factors. There is a geographical variation in the incidence of gastric cancer, possibly explained by differences in food intake. Experimentally it is possible to induce gastric stump carcinoma in rats without the addition of exogenous carcinogens. The aim of this study was: 1) to find the incidence of gastric carcinoma in rats subjected to BII resection and followed for 10 months, and 2) to examine if acetic acid, a common dietary factor, could influence the development of gastric carcinoma. Amongst BII-operated male Wistar rats, infiltrating carcinoma was found in 5/20 on a normal diet and in 5/24 exposed to acetic acid (NS). Benign mucosal changes were seen in 12/20 and 16/24 respectively (NS). With the exception of a profound inflammation in one sham-operated animal, no mucosal pathological changes were found in 24 sham-operated and 24 control animals where no operation was performed.}},
author = {{Ehrnström, Roy and Lindstrom, C G and Arvidsson, S and Sternby, Nils and Nilsson, E and Ehrnstrom, Y M}},
issn = {{1600-0463}},
language = {{eng}},
number = {{12}},
pages = {{878--884}},
publisher = {{John Wiley & Sons Inc.}},
series = {{APMIS : acta pathologica, microbiologica, et immunologica Scandinavica}},
title = {{An experimental study of gastric stump carcinoma in Wistar rats}},
volume = {{103}},
year = {{1995}},
}