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Shiga toxin pathogenesis : kidney complications and renal failure

Obrig, Tom G and Karpman, Diana LU (2012) In Current Topics in Microbiology and Immunology 357. p.36-105
Abstract

The kidneys are the major organs affected in diarrhea-associated hemolytic uremic syndrome (D(+)HUS). The pathophysiology of renal disease in D(+)HUS is largely the result of the interaction between bacterial virulence factors such as Shiga toxin and lipopolysaccharide and host cells in the kidney and in the blood circulation. This chapter describes in detail the current knowledge of how these bacterial toxins may lead to kidney disease and renal failure. The toxin receptors expressed by specific blood and resident renal cell types are also discussed as are the actions of the toxins on these cells.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Blood Cells, Fibrinolysis, Glycolipids, Hemolytic-Uremic Syndrome, Humans, Inflammation, Kidney, Lipopolysaccharides, Renal Insufficiency, Shiga Toxin, Sphingolipids, Thrombosis, Virulence Factors
in
Current Topics in Microbiology and Immunology
volume
357
pages
32 pages
publisher
Springer
external identifiers
  • scopus:84857829010
ISSN
0070-217X
DOI
10.1007/82_2011_172
language
English
LU publication?
yes
id
0d0f4341-28d7-418d-a02f-20874e45c9da
date added to LUP
2017-02-08 15:52:56
date last changed
2017-10-22 05:26:15
@article{0d0f4341-28d7-418d-a02f-20874e45c9da,
  abstract     = {<p>The kidneys are the major organs affected in diarrhea-associated hemolytic uremic syndrome (D(+)HUS). The pathophysiology of renal disease in D(+)HUS is largely the result of the interaction between bacterial virulence factors such as Shiga toxin and lipopolysaccharide and host cells in the kidney and in the blood circulation. This chapter describes in detail the current knowledge of how these bacterial toxins may lead to kidney disease and renal failure. The toxin receptors expressed by specific blood and resident renal cell types are also discussed as are the actions of the toxins on these cells.</p>},
  author       = {Obrig, Tom G and Karpman, Diana},
  issn         = {0070-217X},
  keyword      = {Blood Cells,Fibrinolysis,Glycolipids,Hemolytic-Uremic Syndrome,Humans,Inflammation,Kidney,Lipopolysaccharides,Renal Insufficiency,Shiga Toxin,Sphingolipids,Thrombosis,Virulence Factors},
  language     = {eng},
  pages        = {36--105},
  publisher    = {Springer},
  series       = {Current Topics in Microbiology and Immunology},
  title        = {Shiga toxin pathogenesis : kidney complications and renal failure},
  url          = {http://dx.doi.org/10.1007/82_2011_172},
  volume       = {357},
  year         = {2012},
}