Impact of tuberculosis exposure at home on mortality in children under 5 years of age in Guinea-Bissau
(2011) In Thorax 66(2). p.163-167- Abstract
- Objective To assess mortality related to exposure to tuberculosis (TB) at home among children in urban areas of Guinea-Bissau. Methods In four suburban areas included in the demographic surveillance system of the Bandim Health Project in Bissau, the mortality of children aged <5 years living with an adult with TB was compared with the mortality of children in the general population. Results Children <5 years of age exposed to an adult with intrathoracic TB had 66% higher mortality than unexposed children (HR 1.66, 95% CI 1.2 to 2.3). The risk was higher for children living in the same family as a TB case (HR 2.15, 95% CI 1.3 to 3.7) than for children living in the same house but not belonging to the same family as the TB case (HR... (More)
- Objective To assess mortality related to exposure to tuberculosis (TB) at home among children in urban areas of Guinea-Bissau. Methods In four suburban areas included in the demographic surveillance system of the Bandim Health Project in Bissau, the mortality of children aged <5 years living with an adult with TB was compared with the mortality of children in the general population. Results Children <5 years of age exposed to an adult with intrathoracic TB had 66% higher mortality than unexposed children (HR 1.66, 95% CI 1.2 to 2.3). The risk was higher for children living in the same family as a TB case (HR 2.15, 95% CI 1.3 to 3.7) than for children living in the same house but not belonging to the same family as the TB case (HR 1.51, 95% CI 1.0 to 2.2). For children whose mother had TB, mortality was increased eightfold (HR 7.82, 95% CI 2.1 to 30). The risk of death was particularly increased from 6 months following exposure (HR 2.16, 95% CI 1.5 to 3.2) and the highest rate of excess mortality was found in children aged 3-4 years. Excess mortality was highest among children with close contact with an adult with sputum-positive pulmonary TB (HR 1.90, 95% CI 1.1 to 3.2), but contact with a sputum-negative case was also associated with increased mortality (HR 1.55, 95% CI 1.0 to 2.3). Adjusting for potential confounding factors did not change these results. The mortality among children living in the same houses 3 years earlier was not increased (HR 0.90, 95% CI 0.6 to 1.3). Conclusion Intimate family contact with a TB case represents a significant risk factor for child mortality in a low-income country. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1876870
- author
- Gomes, Victor F. ; Andersen, Andreas ; Wejse, Christian ; Oliveira, Ines ; Vieira, Fina J. ; Joaquim, Luis Carlos ; Vieira, Cesaltina S. ; Aaby, Peter and Gustafson, Per LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Thorax
- volume
- 66
- issue
- 2
- pages
- 163 - 167
- publisher
- BMJ Publishing Group
- external identifiers
-
- wos:000286459000016
- scopus:79251636433
- ISSN
- 1468-3296
- DOI
- 10.1136/thx.2010.141309
- language
- English
- LU publication?
- yes
- id
- 0d22c7aa-19d0-49fc-9153-e79caa0a62b1 (old id 1876870)
- date added to LUP
- 2016-04-01 14:07:48
- date last changed
- 2022-01-27 22:55:44
@article{0d22c7aa-19d0-49fc-9153-e79caa0a62b1, abstract = {{Objective To assess mortality related to exposure to tuberculosis (TB) at home among children in urban areas of Guinea-Bissau. Methods In four suburban areas included in the demographic surveillance system of the Bandim Health Project in Bissau, the mortality of children aged <5 years living with an adult with TB was compared with the mortality of children in the general population. Results Children <5 years of age exposed to an adult with intrathoracic TB had 66% higher mortality than unexposed children (HR 1.66, 95% CI 1.2 to 2.3). The risk was higher for children living in the same family as a TB case (HR 2.15, 95% CI 1.3 to 3.7) than for children living in the same house but not belonging to the same family as the TB case (HR 1.51, 95% CI 1.0 to 2.2). For children whose mother had TB, mortality was increased eightfold (HR 7.82, 95% CI 2.1 to 30). The risk of death was particularly increased from 6 months following exposure (HR 2.16, 95% CI 1.5 to 3.2) and the highest rate of excess mortality was found in children aged 3-4 years. Excess mortality was highest among children with close contact with an adult with sputum-positive pulmonary TB (HR 1.90, 95% CI 1.1 to 3.2), but contact with a sputum-negative case was also associated with increased mortality (HR 1.55, 95% CI 1.0 to 2.3). Adjusting for potential confounding factors did not change these results. The mortality among children living in the same houses 3 years earlier was not increased (HR 0.90, 95% CI 0.6 to 1.3). Conclusion Intimate family contact with a TB case represents a significant risk factor for child mortality in a low-income country.}}, author = {{Gomes, Victor F. and Andersen, Andreas and Wejse, Christian and Oliveira, Ines and Vieira, Fina J. and Joaquim, Luis Carlos and Vieira, Cesaltina S. and Aaby, Peter and Gustafson, Per}}, issn = {{1468-3296}}, language = {{eng}}, number = {{2}}, pages = {{163--167}}, publisher = {{BMJ Publishing Group}}, series = {{Thorax}}, title = {{Impact of tuberculosis exposure at home on mortality in children under 5 years of age in Guinea-Bissau}}, url = {{http://dx.doi.org/10.1136/thx.2010.141309}}, doi = {{10.1136/thx.2010.141309}}, volume = {{66}}, year = {{2011}}, }