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Glucose homeostasis dependency on acini–islet–acinar (AIA) axis communication : a new possible pathophysiological hypothesis regarding diabetes mellitus

Pierzynowski, Stefan G. LU ; Gregory, Peter C.; Filip, Rafał; Woliński, Jarosław and Pierzynowska, Kateryna Goncharova (2018) In Nutrition and Diabetes 8(1).
Abstract

Studies have highlighted the existence of two intra-pancreatic axes of communication: one involved in the regulation of enzyme production by insulin—the insular–acinar axis; and another involved in the regulation of insulin release by pancreatic enzymes—the acini–insular axis. Previous studies by our laboratory show that pancreatic enzymes can affect blood glucose homeostasis and insulin secretion independently of their digestive functions, both from the gut lumen and probably from the blood. As a result we would like to introduce here the concept of acini–islet–acinar (AIA) axis communication (feedback), which could play an important role in the development of obesity and diabetes type 2. The AIA feedback links the endocrine and... (More)

Studies have highlighted the existence of two intra-pancreatic axes of communication: one involved in the regulation of enzyme production by insulin—the insular–acinar axis; and another involved in the regulation of insulin release by pancreatic enzymes—the acini–insular axis. Previous studies by our laboratory show that pancreatic enzymes can affect blood glucose homeostasis and insulin secretion independently of their digestive functions, both from the gut lumen and probably from the blood. As a result we would like to introduce here the concept of acini–islet–acinar (AIA) axis communication (feedback), which could play an important role in the development of obesity and diabetes type 2. The AIA feedback links the endocrine and exocrine parts of the pancreas and emphasizes the essential role that the pancreas plays, as a single organ, in the regulation of glucose homeostasis by amylase most probably in gut epithelium and by insulin and glucagon in peripheral blood.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nutrition and Diabetes
volume
8
issue
1
publisher
Nature Publishing Group
external identifiers
  • scopus:85054465418
ISSN
2044-4052
DOI
10.1038/s41387-018-0062-9
language
English
LU publication?
yes
id
0d8210f1-788d-4195-bf00-e1ea4d6eac3c
date added to LUP
2018-10-29 13:47:50
date last changed
2019-02-20 11:33:39
@article{0d8210f1-788d-4195-bf00-e1ea4d6eac3c,
  abstract     = {<p>Studies have highlighted the existence of two intra-pancreatic axes of communication: one involved in the regulation of enzyme production by insulin—the insular–acinar axis; and another involved in the regulation of insulin release by pancreatic enzymes—the acini–insular axis. Previous studies by our laboratory show that pancreatic enzymes can affect blood glucose homeostasis and insulin secretion independently of their digestive functions, both from the gut lumen and probably from the blood. As a result we would like to introduce here the concept of acini–islet–acinar (AIA) axis communication (feedback), which could play an important role in the development of obesity and diabetes type 2. The AIA feedback links the endocrine and exocrine parts of the pancreas and emphasizes the essential role that the pancreas plays, as a single organ, in the regulation of glucose homeostasis by amylase most probably in gut epithelium and by insulin and glucagon in peripheral blood.</p>},
  articleno    = {55},
  author       = {Pierzynowski, Stefan G. and Gregory, Peter C. and Filip, Rafał and Woliński, Jarosław and Pierzynowska, Kateryna Goncharova},
  issn         = {2044-4052},
  language     = {eng},
  number       = {1},
  publisher    = {Nature Publishing Group},
  series       = {Nutrition and Diabetes},
  title        = {Glucose homeostasis dependency on acini–islet–acinar (AIA) axis communication : a new possible pathophysiological hypothesis regarding diabetes mellitus},
  url          = {http://dx.doi.org/10.1038/s41387-018-0062-9},
  volume       = {8},
  year         = {2018},
}