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Cell cycle sibling rivalry Cdc2 vs. Cdk2

Kaldis, Philipp LU orcid and Aleem, Eiman (2005) In Cell Cycle 4(11). p.1491-1494
Abstract

It has been long believed that the cyclin-dependent kinase 2 (Cdk2) binds to cyclin E or cyclin A and exclusively promotes the G1/S phase transition and that Cdc2/cyclin B complexes play a major role in mitosis. We now provide evidence that Cdc2 binds to cyclin E (in addition to cyclin A and B) and is able to promote the G1/S transition. This new concept indicates that both Cdk2 and/or Cdc2 can drive cells through G1/S phase in parallel. In this review we discuss the classic cell cycle model and how results from knockout mice provide new evidence that refute this model. We focus on the roles of Cdc2 and p27 in regulating the mammalian cell cycle and propose a new model for cell cycle regulation that... (More)

It has been long believed that the cyclin-dependent kinase 2 (Cdk2) binds to cyclin E or cyclin A and exclusively promotes the G1/S phase transition and that Cdc2/cyclin B complexes play a major role in mitosis. We now provide evidence that Cdc2 binds to cyclin E (in addition to cyclin A and B) and is able to promote the G1/S transition. This new concept indicates that both Cdk2 and/or Cdc2 can drive cells through G1/S phase in parallel. In this review we discuss the classic cell cycle model and how results from knockout mice provide new evidence that refute this model. We focus on the roles of Cdc2 and p27 in regulating the mammalian cell cycle and propose a new model for cell cycle regulation that accommodates these novel findings.

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Please use this url to cite or link to this publication:
author
and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cdc2, Cdk2, Cyclin E, Cyclin-dependent kinase, Knockout mice, p27
in
Cell Cycle
volume
4
issue
11
pages
1491 - 1494
publisher
Landes Bioscience
external identifiers
  • scopus:27744458480
  • pmid:16258277
ISSN
1538-4101
DOI
10.4161/cc.4.11.2124
language
English
LU publication?
no
id
0dedcdf4-d090-411e-a1de-88b05b7cd3f3
date added to LUP
2019-09-18 14:25:32
date last changed
2024-01-01 20:41:03
@article{0dedcdf4-d090-411e-a1de-88b05b7cd3f3,
  abstract     = {{<p>It has been long believed that the cyclin-dependent kinase 2 (Cdk2) binds to cyclin E or cyclin A and exclusively promotes the G<sub>1</sub>/S phase transition and that Cdc2/cyclin B complexes play a major role in mitosis. We now provide evidence that Cdc2 binds to cyclin E (in addition to cyclin A and B) and is able to promote the G<sub>1</sub>/S transition. This new concept indicates that both Cdk2 and/or Cdc2 can drive cells through G<sub>1</sub>/S phase in parallel. In this review we discuss the classic cell cycle model and how results from knockout mice provide new evidence that refute this model. We focus on the roles of Cdc2 and p27 in regulating the mammalian cell cycle and propose a new model for cell cycle regulation that accommodates these novel findings.</p>}},
  author       = {{Kaldis, Philipp and Aleem, Eiman}},
  issn         = {{1538-4101}},
  keywords     = {{Cdc2; Cdk2; Cyclin E; Cyclin-dependent kinase; Knockout mice; p27}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{11}},
  pages        = {{1491--1494}},
  publisher    = {{Landes Bioscience}},
  series       = {{Cell Cycle}},
  title        = {{Cell cycle sibling rivalry Cdc2 vs. Cdk2}},
  url          = {{http://dx.doi.org/10.4161/cc.4.11.2124}},
  doi          = {{10.4161/cc.4.11.2124}},
  volume       = {{4}},
  year         = {{2005}},
}