Degradation of antiproteinases, complement and fibronectin in chronic leg ulcers
(2000) In Acta Dermato-Venereologica 80(3). p.179-179- Abstract
- It has been proposed that excessive and uncontrolled proteolytic activity is an important pathogenetic factor for chronic wounds. Identification of molecules that either control or reflect proteolysis in wounds may prove to be useful in determining wound healing activity. In this study wound fluid was sampled under a polyurethane dressing or on hydrophilic glass filters. Multiple chronic wound fluid components were identified; viz. the previously described alpha2-macroglobulin, alpha1-antitrypsin and fibronectin, as well as "novel" wound fluid molecules such as complement factor C3, inter-alpha-inhibitor, kininogen, IgG, IgA, C-reactive protein, tetranectin, orosomucoid and ceruloplasmin. There appeared to be a highly variable degradation... (More)
- It has been proposed that excessive and uncontrolled proteolytic activity is an important pathogenetic factor for chronic wounds. Identification of molecules that either control or reflect proteolysis in wounds may prove to be useful in determining wound healing activity. In this study wound fluid was sampled under a polyurethane dressing or on hydrophilic glass filters. Multiple chronic wound fluid components were identified; viz. the previously described alpha2-macroglobulin, alpha1-antitrypsin and fibronectin, as well as "novel" wound fluid molecules such as complement factor C3, inter-alpha-inhibitor, kininogen, IgG, IgA, C-reactive protein, tetranectin, orosomucoid and ceruloplasmin. There appeared to be a highly variable degradation of alpha1-antitrypsin in the wounds; furthermore, the activation of C3 appeared to correlate with the appearance of fibronectin breakdown products. In wound fluid, inter-alpha-inhibitor was degraded. The influence of the sampling procedures was studied. It was shown that contact phase activation must be taken into account in the study of molecules (such as kininogens) activated by hydrophilic charged surfaces. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1118097
- author
- Schmidtchen, Artur LU
- organization
- publishing date
- 2000
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Dermato-Venereologica
- volume
- 80
- issue
- 3
- pages
- 179 - 179
- publisher
- Medical Journals Limited
- external identifiers
-
- pmid:10954207
- scopus:0033816790
- ISSN
- 1651-2057
- DOI
- 10.1080/000155500750042925
- language
- English
- LU publication?
- yes
- id
- 0e09151d-603d-4be4-a0f6-659ced2e08b3 (old id 1118097)
- date added to LUP
- 2016-04-01 16:23:00
- date last changed
- 2022-04-22 21:41:04
@article{0e09151d-603d-4be4-a0f6-659ced2e08b3,
abstract = {{It has been proposed that excessive and uncontrolled proteolytic activity is an important pathogenetic factor for chronic wounds. Identification of molecules that either control or reflect proteolysis in wounds may prove to be useful in determining wound healing activity. In this study wound fluid was sampled under a polyurethane dressing or on hydrophilic glass filters. Multiple chronic wound fluid components were identified; viz. the previously described alpha2-macroglobulin, alpha1-antitrypsin and fibronectin, as well as "novel" wound fluid molecules such as complement factor C3, inter-alpha-inhibitor, kininogen, IgG, IgA, C-reactive protein, tetranectin, orosomucoid and ceruloplasmin. There appeared to be a highly variable degradation of alpha1-antitrypsin in the wounds; furthermore, the activation of C3 appeared to correlate with the appearance of fibronectin breakdown products. In wound fluid, inter-alpha-inhibitor was degraded. The influence of the sampling procedures was studied. It was shown that contact phase activation must be taken into account in the study of molecules (such as kininogens) activated by hydrophilic charged surfaces.}},
author = {{Schmidtchen, Artur}},
issn = {{1651-2057}},
language = {{eng}},
number = {{3}},
pages = {{179--179}},
publisher = {{Medical Journals Limited}},
series = {{Acta Dermato-Venereologica}},
title = {{Degradation of antiproteinases, complement and fibronectin in chronic leg ulcers}},
url = {{http://dx.doi.org/10.1080/000155500750042925}},
doi = {{10.1080/000155500750042925}},
volume = {{80}},
year = {{2000}},
}