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Markers of proteolysis, fibrinolysis, and coagulation in relation to size and growth rate of abdominal aortic aneurysms.

Flondell-Sité, Despina LU ; Lindblad, Bengt LU ; Kölbel, Tilo LU and Gottsäter, Anders LU (2010) In Vascular and Endovascular Surgery 44(4). p.262-268
Abstract
We evaluated whether matrix metalloproteinases (MMPs) 2 and 9, their inhibitors, markers for fibrinolysis, and thrombin activation are associated with diameter and growth of abdominal aortic aneurysms (AAAs). Material and Methods: Matrix metalloproteinases 2 and 9, tissue inhibitor of MMPs (TIMP-1), serpine-1, tPa-serpine-1, and activated protein C- protein C inhibitor (APC-PCI) complex were analyzed in 353 patients with AAA grouped according to AAA size, and 219 gender- and age-matched healthy individuals. Follow-up of AAA growth for up to 7 years was possible in 178 of 353 patients. Results: At baseline, all groups of patients with AAA showed lower levels of MMP-2 and -9, and higher levels of TIMP-1, serpine-1, and t-Pa-serpine-1 than... (More)
We evaluated whether matrix metalloproteinases (MMPs) 2 and 9, their inhibitors, markers for fibrinolysis, and thrombin activation are associated with diameter and growth of abdominal aortic aneurysms (AAAs). Material and Methods: Matrix metalloproteinases 2 and 9, tissue inhibitor of MMPs (TIMP-1), serpine-1, tPa-serpine-1, and activated protein C- protein C inhibitor (APC-PCI) complex were analyzed in 353 patients with AAA grouped according to AAA size, and 219 gender- and age-matched healthy individuals. Follow-up of AAA growth for up to 7 years was possible in 178 of 353 patients. Results: At baseline, all groups of patients with AAA showed lower levels of MMP-2 and -9, and higher levels of TIMP-1, serpine-1, and t-Pa-serpine-1 than controls. Matrix metalloproteinase 2 correlated inversely and APC-PCI complex correlated directly with AAA diameter. We found no correlations between markers for proteolysis, fibrinolysis, coagulation, and yearly AAA growth. CONCLUSION: Matrix metalloproteinase 2 is lower and APC-PCI higher in patients with larger AAA, but the relevance of the markers for AAA growth is far from clarified. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aged, Aged, 80 and over, Aortic Aneurysm, Abdominal/blood, Biomarkers/blood, Blood Coagulation, Case-Control Studies, Disease Progression, Female, Fibrinolysis, Follow-Up Studies, Humans, Male, Matrix Metalloproteinase 2/blood, Matrix Metalloproteinase 9/blood, Middle Aged, Peptide Hydrolases/blood, Plasminogen Activator Inhibitor 1/blood, Prospective Studies, Protein C/metabolism, Protein C Inhibitor/blood, Sweden, Time Factors, Tissue Inhibitor of Metalloproteinase-1/blood, Tissue Plasminogen Activator/blood
in
Vascular and Endovascular Surgery
volume
44
issue
4
pages
7 pages
publisher
SAGE Publications
external identifiers
  • wos:000276803500004
  • pmid:20356864
  • scopus:77951757326
  • pmid:20356864
ISSN
1938-9116
DOI
10.1177/1538574410361971
language
English
LU publication?
yes
id
0e3a31c0-e3c2-4c1d-be1f-55f2d0d96d04 (old id 1598730)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20356864?dopt=Abstract
date added to LUP
2016-04-04 08:41:04
date last changed
2024-02-12 08:17:17
@article{0e3a31c0-e3c2-4c1d-be1f-55f2d0d96d04,
  abstract     = {{We evaluated whether matrix metalloproteinases (MMPs) 2 and 9, their inhibitors, markers for fibrinolysis, and thrombin activation are associated with diameter and growth of abdominal aortic aneurysms (AAAs). Material and Methods: Matrix metalloproteinases 2 and 9, tissue inhibitor of MMPs (TIMP-1), serpine-1, tPa-serpine-1, and activated protein C- protein C inhibitor (APC-PCI) complex were analyzed in 353 patients with AAA grouped according to AAA size, and 219 gender- and age-matched healthy individuals. Follow-up of AAA growth for up to 7 years was possible in 178 of 353 patients. Results: At baseline, all groups of patients with AAA showed lower levels of MMP-2 and -9, and higher levels of TIMP-1, serpine-1, and t-Pa-serpine-1 than controls. Matrix metalloproteinase 2 correlated inversely and APC-PCI complex correlated directly with AAA diameter. We found no correlations between markers for proteolysis, fibrinolysis, coagulation, and yearly AAA growth. CONCLUSION: Matrix metalloproteinase 2 is lower and APC-PCI higher in patients with larger AAA, but the relevance of the markers for AAA growth is far from clarified.}},
  author       = {{Flondell-Sité, Despina and Lindblad, Bengt and Kölbel, Tilo and Gottsäter, Anders}},
  issn         = {{1938-9116}},
  keywords     = {{Aged; Aged, 80 and over; Aortic Aneurysm, Abdominal/blood; Biomarkers/blood; Blood Coagulation; Case-Control Studies; Disease Progression; Female; Fibrinolysis; Follow-Up Studies; Humans; Male; Matrix Metalloproteinase 2/blood; Matrix Metalloproteinase 9/blood; Middle Aged; Peptide Hydrolases/blood; Plasminogen Activator Inhibitor 1/blood; Prospective Studies; Protein C/metabolism; Protein C Inhibitor/blood; Sweden; Time Factors; Tissue Inhibitor of Metalloproteinase-1/blood; Tissue Plasminogen Activator/blood}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{262--268}},
  publisher    = {{SAGE Publications}},
  series       = {{Vascular and Endovascular Surgery}},
  title        = {{Markers of proteolysis, fibrinolysis, and coagulation in relation to size and growth rate of abdominal aortic aneurysms.}},
  url          = {{http://dx.doi.org/10.1177/1538574410361971}},
  doi          = {{10.1177/1538574410361971}},
  volume       = {{44}},
  year         = {{2010}},
}