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RIFM fragrance ingredient safety assessment, p-tolyl acetate, CAS Registry Number 140-39-6

Api, A. M. ; Belmonte, F. ; Belsito, D. ; Biserta, S. ; Botelho, D. ; Bruze, M. LU ; Burton, G. A. ; Buschmann, J. ; Cancellieri, M. A. and Dagli, M. L. , et al. (2019) In Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 134.
Abstract

The existing information supports the use of this material as described in this safety assessment. p-Tolyl acetate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog ethyl p-tolyl carbonate (CAS # 22719-81-9) show that p-tolyl acetate is not expected to be genotoxic. Data on read-across materials p-cresol (CAS # 106-44-5) and acetic acid (CAS # 64-19-7) provide a calculated MOE >100 for the repeated dose and reproductive toxicity endpoints. The skin sensitization endpoint was completed using DST for reactive materials (64 μg/cm2); exposure is below the DST. The... (More)

The existing information supports the use of this material as described in this safety assessment. p-Tolyl acetate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog ethyl p-tolyl carbonate (CAS # 22719-81-9) show that p-tolyl acetate is not expected to be genotoxic. Data on read-across materials p-cresol (CAS # 106-44-5) and acetic acid (CAS # 64-19-7) provide a calculated MOE >100 for the repeated dose and reproductive toxicity endpoints. The skin sensitization endpoint was completed using DST for reactive materials (64 μg/cm2); exposure is below the DST. The phototoxicity/photoallergenicity endpoints were evaluated based on UV spectra; p-tolyl acetate is not expected to be phototoxic/photoallergenic. The local respiratory toxicity endpoint was evaluated using the TTC for a Cramer Class I material, and the exposure to p-tolyl acetate is below the TTC (1.4 mg/day).The environmental endpoints were evaluated; p-tolyl acetate was found not to be PBT as per the IFRA Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC), are <1.

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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Developmental, and Reproductive, Environmental Safety, Genotoxicity, Local, Phototoxicity/Photoallergenicity, Repeated Dose, Respiratory Toxicity, Skin Sensitization, Toxicity
in
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
volume
134
article number
111002
publisher
Elsevier
external identifiers
  • pmid:31785315
  • scopus:85077175277
ISSN
1873-6351
DOI
10.1016/j.fct.2019.111002
language
English
LU publication?
no
id
0e776c6f-9c73-4fa2-87fb-b626d2992b61
date added to LUP
2020-01-10 14:36:17
date last changed
2022-04-18 20:10:26
@article{0e776c6f-9c73-4fa2-87fb-b626d2992b61,
  abstract     = {{<p>The existing information supports the use of this material as described in this safety assessment. p-Tolyl acetate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog ethyl p-tolyl carbonate (CAS # 22719-81-9) show that p-tolyl acetate is not expected to be genotoxic. Data on read-across materials p-cresol (CAS # 106-44-5) and acetic acid (CAS # 64-19-7) provide a calculated MOE &gt;100 for the repeated dose and reproductive toxicity endpoints. The skin sensitization endpoint was completed using DST for reactive materials (64 μg/cm2); exposure is below the DST. The phototoxicity/photoallergenicity endpoints were evaluated based on UV spectra; p-tolyl acetate is not expected to be phototoxic/photoallergenic. The local respiratory toxicity endpoint was evaluated using the TTC for a Cramer Class I material, and the exposure to p-tolyl acetate is below the TTC (1.4 mg/day).The environmental endpoints were evaluated; p-tolyl acetate was found not to be PBT as per the IFRA Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC), are &lt;1.</p>}},
  author       = {{Api, A. M. and Belmonte, F. and Belsito, D. and Biserta, S. and Botelho, D. and Bruze, M. and Burton, G. A. and Buschmann, J. and Cancellieri, M. A. and Dagli, M. L. and Date, M. and Dekant, W. and Deodhar, C. and Fryer, A. D. and Gadhia, S. and Jones, L. and Joshi, K. and Lapczynski, A. and Lavelle, M. and Liebler, D. C. and Na, M. and O'Brien, D. and Patel, A. and Penning, T. M. and Ritacco, G. and Rodriguez-Ropero, F. and Romine, J. and Sadekar, N. and Salvito, D. and Schultz, T. W. and Siddiqi, F. and Sipes, I. G. and Sullivan, G. and Thakkar, Y. and Tokura, Y. and Tsang, S.}},
  issn         = {{1873-6351}},
  keywords     = {{Developmental, and Reproductive; Environmental Safety; Genotoxicity; Local; Phototoxicity/Photoallergenicity; Repeated Dose; Respiratory Toxicity; Skin Sensitization; Toxicity}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association}},
  title        = {{RIFM fragrance ingredient safety assessment, p-tolyl acetate, CAS Registry Number 140-39-6}},
  url          = {{http://dx.doi.org/10.1016/j.fct.2019.111002}},
  doi          = {{10.1016/j.fct.2019.111002}},
  volume       = {{134}},
  year         = {{2019}},
}