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Prevalence of Celiac Disease Autoimmunity in Ethiopian Pregnant Women: A Cross Sectional Study from the Oromia region

Gudeta, Adugna Negussie LU ; Brundin, Charlotte LU ; Muleta Feyissa, Daba ; Balcha, Taye Tolera LU and Agardh, Daniel LU (2019) In International Journal of Celiac Disease 7(3). p.74-77
Abstract
Celiac disease is a chronic small bowel disease induced by ingestion of gluten in genetically susceptible individuals affecting 1% among Caucasians in the Western world. The prevalence of celiac disease is still unknown in most developing countries, especially in Africa which suffer from lack of resources to perform screening of the general population. The aim of this study was to determine the prevalence of celiac disease autoimmunity in women undergoing antenatal care in selected Ethiopian health institutes. A total of 1942 pregnant women were included at median 25 (range 15-45) years of age who were attending antenatal care at 14 health centers of Central and South-East Oromia regional state of Ethiopia. Serum samples were analyzed for... (More)
Celiac disease is a chronic small bowel disease induced by ingestion of gluten in genetically susceptible individuals affecting 1% among Caucasians in the Western world. The prevalence of celiac disease is still unknown in most developing countries, especially in Africa which suffer from lack of resources to perform screening of the general population. The aim of this study was to determine the prevalence of celiac disease autoimmunity in women undergoing antenatal care in selected Ethiopian health institutes. A total of 1942 pregnant women were included at median 25 (range 15-45) years of age who were attending antenatal care at 14 health centers of Central and South-East Oromia regional state of Ethiopia. Serum samples were analyzed for both IgA and IgG autoantibodies against tissue transglutaminase (tTG) using radioligand binding assays. Celiac disease autoimmunity defined as testing positive for both of IgA-tTG and IgG-tTG. In all, 4 of 1942 (0.2%) were positive for IgG-tTG of whom one participant (0.05%) was positive for both IgA-tTG and IgG-tTG and defined as having celiac disease autoimmunity. Based on these results, it was concluded that celiac disease autoimmunity is expected to be less common among the female adult Ethiopian population compared with the expected prevalence in Caucasians. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Celiac Disease
volume
7
issue
3
pages
74 - 77
publisher
Science and Education Publishing
DOI
10.12691/ijcd-7-3-1
language
English
LU publication?
yes
id
0eaf8b14-81ae-4b52-9d54-09b5ecbabadf
date added to LUP
2021-12-09 15:08:43
date last changed
2021-12-10 09:34:28
@article{0eaf8b14-81ae-4b52-9d54-09b5ecbabadf,
  abstract     = {{Celiac disease is a chronic small bowel disease induced by ingestion of gluten in genetically susceptible individuals affecting 1% among Caucasians in the Western world. The prevalence of celiac disease is still unknown in most developing countries, especially in Africa which suffer from lack of resources to perform screening of the general population. The aim of this study was to determine the prevalence of celiac disease autoimmunity in women undergoing antenatal care in selected Ethiopian health institutes. A total of 1942 pregnant women were included at median 25 (range 15-45) years of age who were attending antenatal care at 14 health centers of Central and South-East Oromia regional state of Ethiopia. Serum samples were analyzed for both IgA and IgG autoantibodies against tissue transglutaminase (tTG) using radioligand binding assays. Celiac disease autoimmunity defined as testing positive for both of IgA-tTG and IgG-tTG. In all, 4 of 1942 (0.2%) were positive for IgG-tTG of whom one participant (0.05%) was positive for both IgA-tTG and IgG-tTG and defined as having celiac disease autoimmunity. Based on these results, it was concluded that celiac disease autoimmunity is expected to be less common among the female adult Ethiopian population compared with the expected prevalence in Caucasians.}},
  author       = {{Gudeta, Adugna Negussie and Brundin, Charlotte and Muleta Feyissa, Daba and Balcha, Taye Tolera and Agardh, Daniel}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{74--77}},
  publisher    = {{Science and Education Publishing}},
  series       = {{International Journal of Celiac Disease}},
  title        = {{Prevalence of Celiac Disease Autoimmunity in Ethiopian Pregnant Women: A Cross Sectional Study from the Oromia region}},
  url          = {{http://dx.doi.org/10.12691/ijcd-7-3-1}},
  doi          = {{10.12691/ijcd-7-3-1}},
  volume       = {{7}},
  year         = {{2019}},
}