Laparoscopic versus open distal pancreatectomy (LAPOP) : Study protocol for a single center, nonblinded, randomized controlled trial
(2019) In Trials 20(1).- Abstract
Background: Earlier nonrandomized studies have suggested that laparoscopic distal pancreatectomy (LDP) is advantageous compared with open distal pancreatectomy (ODP) regarding hospital stay, blood loss, and recovery. Only one randomized study has been conducted showing reduced time to functional recovery after LDP compared with ODP. Methods: LAPOP is a prospective randomized, nonblinded, parallel-group, single-center superiority trial. Sixty patients with lesions in the pancreatic body or tail that are found by a multidisciplinary tumor board to need surgical resection will be randomized to receive LDP or ODP. The primary outcome variable is postoperative hospital stay, and secondary outcomes include functional recovery (defined as no... (More)
Background: Earlier nonrandomized studies have suggested that laparoscopic distal pancreatectomy (LDP) is advantageous compared with open distal pancreatectomy (ODP) regarding hospital stay, blood loss, and recovery. Only one randomized study has been conducted showing reduced time to functional recovery after LDP compared with ODP. Methods: LAPOP is a prospective randomized, nonblinded, parallel-group, single-center superiority trial. Sixty patients with lesions in the pancreatic body or tail that are found by a multidisciplinary tumor board to need surgical resection will be randomized to receive LDP or ODP. The primary outcome variable is postoperative hospital stay, and secondary outcomes include functional recovery (defined as no need for intravenous medications or fluids and as the ability of an ambulatory patient to perform activities of daily life), perioperative bleeding, complications, need for pain medication, and quality of life comparison. Discussion: The LAPOP trial will test the hypothesis that LDP reduces postoperative hospital stay compared with ODP.
(Less)
- author
- Björnsson, Bergthor ; Sandström, Per ; Larsson, Anna Lindhoff ; Hjalmarsson, Claes LU and Gasslander, Thomas
- organization
- publishing date
- 2019-06-13
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Distal pancreatectomy, Laparoscopic, Minimally invasive, Pancreatic surgery
- in
- Trials
- volume
- 20
- issue
- 1
- article number
- 356
- publisher
- BioMed Central (BMC)
- external identifiers
-
- scopus:85067291023
- pmid:31196166
- ISSN
- 1745-6215
- DOI
- 10.1186/s13063-019-3460-y
- language
- English
- LU publication?
- yes
- id
- 0ee816b3-2d4c-490c-a23d-8e1c34d6cf6a
- date added to LUP
- 2019-06-28 08:59:20
- date last changed
- 2024-03-19 15:30:26
@article{0ee816b3-2d4c-490c-a23d-8e1c34d6cf6a,
abstract = {{<p>Background: Earlier nonrandomized studies have suggested that laparoscopic distal pancreatectomy (LDP) is advantageous compared with open distal pancreatectomy (ODP) regarding hospital stay, blood loss, and recovery. Only one randomized study has been conducted showing reduced time to functional recovery after LDP compared with ODP. Methods: LAPOP is a prospective randomized, nonblinded, parallel-group, single-center superiority trial. Sixty patients with lesions in the pancreatic body or tail that are found by a multidisciplinary tumor board to need surgical resection will be randomized to receive LDP or ODP. The primary outcome variable is postoperative hospital stay, and secondary outcomes include functional recovery (defined as no need for intravenous medications or fluids and as the ability of an ambulatory patient to perform activities of daily life), perioperative bleeding, complications, need for pain medication, and quality of life comparison. Discussion: The LAPOP trial will test the hypothesis that LDP reduces postoperative hospital stay compared with ODP.</p>}},
author = {{Björnsson, Bergthor and Sandström, Per and Larsson, Anna Lindhoff and Hjalmarsson, Claes and Gasslander, Thomas}},
issn = {{1745-6215}},
keywords = {{Distal pancreatectomy; Laparoscopic; Minimally invasive; Pancreatic surgery}},
language = {{eng}},
month = {{06}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{Trials}},
title = {{Laparoscopic versus open distal pancreatectomy (LAPOP) : Study protocol for a single center, nonblinded, randomized controlled trial}},
url = {{http://dx.doi.org/10.1186/s13063-019-3460-y}},
doi = {{10.1186/s13063-019-3460-y}},
volume = {{20}},
year = {{2019}},
}