Effect of a 3-year lifestyle intervention on telomere length in participants from PREDIMED-Plus : A randomized trial
(2023) In Clinical Nutrition 42(9). p.1581-1587- Abstract
Background & aims: Short telomeres have been observed in chronic disease patients. Identifying environmental and lifestyle factors that could reduce telomere attrition is crucial for disease prevention. The aim of this work was to determine whether weight-loss induced by an energy-reduced Mediterranean diet (erMedDiet) and physical activity (PA) could modify telomere length (TL). Methods: In 317 randomized non-smoker participants (mean age, 65.8 ± 4.98 years) with metabolic syndrome from two “Prevención con Dieta Mediterránea-Plus” (PREDIMED-Plus) trial centers, we evaluated MedDiet adherence, PA, anthropometric variables and TL at baseline and after a 3-year intervention using an intensive lifestyle program (IG) with an erMedDiet... (More)
Background & aims: Short telomeres have been observed in chronic disease patients. Identifying environmental and lifestyle factors that could reduce telomere attrition is crucial for disease prevention. The aim of this work was to determine whether weight-loss induced by an energy-reduced Mediterranean diet (erMedDiet) and physical activity (PA) could modify telomere length (TL). Methods: In 317 randomized non-smoker participants (mean age, 65.8 ± 4.98 years) with metabolic syndrome from two “Prevención con Dieta Mediterránea-Plus” (PREDIMED-Plus) trial centers, we evaluated MedDiet adherence, PA, anthropometric variables and TL at baseline and after a 3-year intervention using an intensive lifestyle program (IG) with an erMedDiet and PA or an unrestricted MedDiet without PA promotion (CG). Results: Participants in the IG displayed greater 3-year weight reductions (−3.7 ± 4 kg, P < 0.001) compared to those in the CG. No differences in TL changes between groups were observed in the cohort as a whole. However, an interaction was observed between the intervention group and sex for TL changes (pinteraction = 0.039). Women in the IG showed an increase in TL after 3-y (+0.25 ± 0.9, relative units) compared to women in the CG (−0.07 ± 1.0) (pANCOVA = 0.036), whereas no differences between groups were observed in men. Women in the IG had a lower risk of telomere shortening after the intervention (OR = 0.17, 95%CI: 0.05–0.64, p = 0.008) compared to women in the CG. Conclusions: A 3-year lifestyle intervention based on an erMedDiet and PA slowed telomere shortening in women but not in men. Trial registration: ISRCTN, ISRCTN89898870. Registered 24 July 2014- Retrospectively registered, https://www.isrctn.com/ISRCTN89898870.
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- author
- Marti, Amelia ; Fernández de la Puente, María ; Canudas, Silvia ; Zalba, Guillermo ; Razquin, Cristina ; Valle-Hita, Cristina ; Fitó, Montse ; Martínez-González, Miguel Ángel ; García-Calzón, Sonia LU and Salas-Salvadó, Jordi
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Calorie restriction, Mediterranean diet, Physical activity, Randomized controlled trial, Telomere length
- in
- Clinical Nutrition
- volume
- 42
- issue
- 9
- pages
- 7 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:37478811
- scopus:85165288007
- ISSN
- 0261-5614
- DOI
- 10.1016/j.clnu.2023.06.030
- language
- English
- LU publication?
- yes
- id
- 0ef91df6-7af0-428e-a433-926ce27d57e6
- date added to LUP
- 2023-09-01 15:27:51
- date last changed
- 2024-04-20 03:27:30
@article{0ef91df6-7af0-428e-a433-926ce27d57e6,
abstract = {{<p>Background & aims: Short telomeres have been observed in chronic disease patients. Identifying environmental and lifestyle factors that could reduce telomere attrition is crucial for disease prevention. The aim of this work was to determine whether weight-loss induced by an energy-reduced Mediterranean diet (erMedDiet) and physical activity (PA) could modify telomere length (TL). Methods: In 317 randomized non-smoker participants (mean age, 65.8 ± 4.98 years) with metabolic syndrome from two “Prevención con Dieta Mediterránea-Plus” (PREDIMED-Plus) trial centers, we evaluated MedDiet adherence, PA, anthropometric variables and TL at baseline and after a 3-year intervention using an intensive lifestyle program (IG) with an erMedDiet and PA or an unrestricted MedDiet without PA promotion (CG). Results: Participants in the IG displayed greater 3-year weight reductions (−3.7 ± 4 kg, P < 0.001) compared to those in the CG. No differences in TL changes between groups were observed in the cohort as a whole. However, an interaction was observed between the intervention group and sex for TL changes (p<sub>interaction</sub> = 0.039). Women in the IG showed an increase in TL after 3-y (+0.25 ± 0.9, relative units) compared to women in the CG (−0.07 ± 1.0) (p<sub>ANCOVA</sub> = 0.036), whereas no differences between groups were observed in men. Women in the IG had a lower risk of telomere shortening after the intervention (OR = 0.17, 95%CI: 0.05–0.64, p = 0.008) compared to women in the CG. Conclusions: A 3-year lifestyle intervention based on an erMedDiet and PA slowed telomere shortening in women but not in men. Trial registration: ISRCTN, ISRCTN89898870. Registered 24 July 2014- Retrospectively registered, https://www.isrctn.com/ISRCTN89898870.</p>}},
author = {{Marti, Amelia and Fernández de la Puente, María and Canudas, Silvia and Zalba, Guillermo and Razquin, Cristina and Valle-Hita, Cristina and Fitó, Montse and Martínez-González, Miguel Ángel and García-Calzón, Sonia and Salas-Salvadó, Jordi}},
issn = {{0261-5614}},
keywords = {{Calorie restriction; Mediterranean diet; Physical activity; Randomized controlled trial; Telomere length}},
language = {{eng}},
number = {{9}},
pages = {{1581--1587}},
publisher = {{Elsevier}},
series = {{Clinical Nutrition}},
title = {{Effect of a 3-year lifestyle intervention on telomere length in participants from PREDIMED-Plus : A randomized trial}},
url = {{http://dx.doi.org/10.1016/j.clnu.2023.06.030}},
doi = {{10.1016/j.clnu.2023.06.030}},
volume = {{42}},
year = {{2023}},
}