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Genetic factors influencing the risk of multiple myeloma bone disease.

Johnson, D C ; Weinhold, N ; Mitchell, J ; Chen, B ; Stephens, O W ; Försti, Asta LU ; Nickel, J ; Kaiser, M ; Gregory, W A and Cairns, D , et al. (2016) In Leukemia 30. p.883-888
Abstract
A major complication of multiple myeloma (MM) is the development of osteolytic lesions, fractures and bone pain. To identify genetic variants influencing the development of MM bone disease (MBD), we analyzed MM patients of European ancestry (totalling 3774) which had been radiologically surveyed for MBD. Each patient had been genotyped for ~600 000 SNPs with genotypes for six million common variants imputed using 1000Genomes Project and UK10K as reference. We identified a locus at 8q24.12 for MBD (rs4407910, OPG/TNFRSF11B, odds ratio [OR]=1.38, P=4.09 × 10(-9)) and a promising association at 19q13.43 (rs74676832, OR=1.97, P=9.33 × 10(-7)). Our findings demonstrate that germline variation influences MBD and highlights the importance of... (More)
A major complication of multiple myeloma (MM) is the development of osteolytic lesions, fractures and bone pain. To identify genetic variants influencing the development of MM bone disease (MBD), we analyzed MM patients of European ancestry (totalling 3774) which had been radiologically surveyed for MBD. Each patient had been genotyped for ~600 000 SNPs with genotypes for six million common variants imputed using 1000Genomes Project and UK10K as reference. We identified a locus at 8q24.12 for MBD (rs4407910, OPG/TNFRSF11B, odds ratio [OR]=1.38, P=4.09 × 10(-9)) and a promising association at 19q13.43 (rs74676832, OR=1.97, P=9.33 × 10(-7)). Our findings demonstrate that germline variation influences MBD and highlights the importance of RANK/RANKL/OPG pathway in MBD development. These findings will contribute to the development of future strategies for prevention of MBD in the early precancerous phases of MM.Leukemia accepted article preview online, 16 December 2015. doi:10.1038/leu.2015.342. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Leukemia
volume
30
pages
883 - 888
publisher
Nature Publishing Group
external identifiers
  • pmid:26669972
  • scopus:84954533526
  • wos:000374123100014
  • pmid:26669972
ISSN
1476-5551
DOI
10.1038/leu.2015.342
language
English
LU publication?
yes
id
0efbc7fb-c687-4c2a-90bd-01cd095124b5 (old id 8504737)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26669972?dopt=Abstract
date added to LUP
2016-04-04 09:18:38
date last changed
2022-03-15 18:42:07
@article{0efbc7fb-c687-4c2a-90bd-01cd095124b5,
  abstract     = {{A major complication of multiple myeloma (MM) is the development of osteolytic lesions, fractures and bone pain. To identify genetic variants influencing the development of MM bone disease (MBD), we analyzed MM patients of European ancestry (totalling 3774) which had been radiologically surveyed for MBD. Each patient had been genotyped for ~600 000 SNPs with genotypes for six million common variants imputed using 1000Genomes Project and UK10K as reference. We identified a locus at 8q24.12 for MBD (rs4407910, OPG/TNFRSF11B, odds ratio [OR]=1.38, P=4.09 × 10(-9)) and a promising association at 19q13.43 (rs74676832, OR=1.97, P=9.33 × 10(-7)). Our findings demonstrate that germline variation influences MBD and highlights the importance of RANK/RANKL/OPG pathway in MBD development. These findings will contribute to the development of future strategies for prevention of MBD in the early precancerous phases of MM.Leukemia accepted article preview online, 16 December 2015. doi:10.1038/leu.2015.342.}},
  author       = {{Johnson, D C and Weinhold, N and Mitchell, J and Chen, B and Stephens, O W and Försti, Asta and Nickel, J and Kaiser, M and Gregory, W A and Cairns, D and Jackson, G H and Hoffmann, P and Noethen, M M and Hillengass, J and Bertsch, U and Barlogie, B and Davis, F E and Hemminki, Kari and Goldschmidt, H and Houlston, R S and Morgan, G J}},
  issn         = {{1476-5551}},
  language     = {{eng}},
  pages        = {{883--888}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Leukemia}},
  title        = {{Genetic factors influencing the risk of multiple myeloma bone disease.}},
  url          = {{http://dx.doi.org/10.1038/leu.2015.342}},
  doi          = {{10.1038/leu.2015.342}},
  volume       = {{30}},
  year         = {{2016}},
}