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A scintillation camera technique for measurements of the reticuloendothelial function -Comparison of different methods for measuring RES function

Rydén, Stefan ; Strand, Sven Erik LU ; Palmer, John LU ; Stenram, Unne LU ; Hafström, Larsolof and Persson, Bertil LU orcid (1982) In European Journal Of Nuclear Medicine 7. p.16-21
Abstract

A highly standardized 99mTc-sulphur colloid was used to evaluate reticuloendothelial system (RES)-function in the normal rat and after RE blockade by gelatin (Haemaccel). Activity distribution in the animals was measured with a scintillation camera technique. Total uptake of activity in the liver was estimated. From the time-activity curves over the liver, the phagocytic index (kphag) was evaluated. Estimation of the uptake rate of the labelled colloid into the liver and into other parts of the RES was also performed using a twocompartment model. Different methods of evaluation of RE function were compared. It was shown that for a proper estimation of the RE function, the whole uptake curve must be considered.... (More)

A highly standardized 99mTc-sulphur colloid was used to evaluate reticuloendothelial system (RES)-function in the normal rat and after RE blockade by gelatin (Haemaccel). Activity distribution in the animals was measured with a scintillation camera technique. Total uptake of activity in the liver was estimated. From the time-activity curves over the liver, the phagocytic index (kphag) was evaluated. Estimation of the uptake rate of the labelled colloid into the liver and into other parts of the RES was also performed using a twocompartment model. Different methods of evaluation of RE function were compared. It was shown that for a proper estimation of the RE function, the whole uptake curve must be considered. Gelatin (Haemaccel) significantly reduced the total colloid uptake by the liver. The colloid uptake rate into the liver was also significantly reduced. Liver specimens after colloid injection were examined by light and electron microscopy showing vacuolation of hepatocytes and sinusoidal cells probably due to pinocytosis. The technique described enables functional studies of the RES. It has the advantage of noninvasive registrations and is based on the same technical facilities as used for routine liver scintigraphy.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal Of Nuclear Medicine
volume
7
pages
16 - 21
publisher
Springer
external identifiers
  • scopus:0020081623
  • pmid:7060599
ISSN
0340-6997
DOI
10.1007/BF00275239
language
English
LU publication?
yes
id
0f005c1d-4d55-4ce8-89b5-cc2c8af6fa67
date added to LUP
2020-08-15 17:13:49
date last changed
2024-01-02 17:00:51
@article{0f005c1d-4d55-4ce8-89b5-cc2c8af6fa67,
  abstract     = {{<p>A highly standardized <sup>99m</sup>Tc-sulphur colloid was used to evaluate reticuloendothelial system (RES)-function in the normal rat and after RE blockade by gelatin (Haemaccel). Activity distribution in the animals was measured with a scintillation camera technique. Total uptake of activity in the liver was estimated. From the time-activity curves over the liver, the phagocytic index (k<sub>phag</sub>) was evaluated. Estimation of the uptake rate of the labelled colloid into the liver and into other parts of the RES was also performed using a twocompartment model. Different methods of evaluation of RE function were compared. It was shown that for a proper estimation of the RE function, the whole uptake curve must be considered. Gelatin (Haemaccel) significantly reduced the total colloid uptake by the liver. The colloid uptake rate into the liver was also significantly reduced. Liver specimens after colloid injection were examined by light and electron microscopy showing vacuolation of hepatocytes and sinusoidal cells probably due to pinocytosis. The technique described enables functional studies of the RES. It has the advantage of noninvasive registrations and is based on the same technical facilities as used for routine liver scintigraphy.</p>}},
  author       = {{Rydén, Stefan and Strand, Sven Erik and Palmer, John and Stenram, Unne and Hafström, Larsolof and Persson, Bertil}},
  issn         = {{0340-6997}},
  language     = {{eng}},
  pages        = {{16--21}},
  publisher    = {{Springer}},
  series       = {{European Journal Of Nuclear Medicine}},
  title        = {{A scintillation camera technique for measurements of the reticuloendothelial function -Comparison of different methods for measuring RES function}},
  url          = {{http://dx.doi.org/10.1007/BF00275239}},
  doi          = {{10.1007/BF00275239}},
  volume       = {{7}},
  year         = {{1982}},
}