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Combined lifestyle factors and the risk of LADA and type 2 diabetes – Results from a Swedish population-based case-control study

Herzog, Katharina ; Ahlqvist, Emma LU ; Alfredsson, Lars ; Groop, Leif LU ; Hjort, Rebecka ; Löfvenborg, Josefin E. ; Tuomi, Tiinamaija LU orcid and Carlsson, Sofia (2021) In Diabetes Research and Clinical Practice 174.
Abstract

Aims: We investigated the risk of latent autoimmune diabetes in adults (LADA) and type 2 diabetes in relation to a healthy lifestyle, the proportion of patients attributable to an unhealthy lifestyle, and the influence of family history of diabetes (FHD) and genetic susceptibility. Methods: The population-based study included incident LADA (n = 571), type 2 diabetes (n = 1962), and matched controls (n = 2217). A healthy lifestyle was defined by BMI < 25 kg/m2, moderate-to-high physical activity, a healthy diet, no smoking, and moderate alcohol consumption. We estimated odds ratios (OR) with 95% confidence intervals (CIs) adjusted for age, sex, education, and FHD. Results: Compared to a poor/moderate lifestyle, a healthy... (More)

Aims: We investigated the risk of latent autoimmune diabetes in adults (LADA) and type 2 diabetes in relation to a healthy lifestyle, the proportion of patients attributable to an unhealthy lifestyle, and the influence of family history of diabetes (FHD) and genetic susceptibility. Methods: The population-based study included incident LADA (n = 571), type 2 diabetes (n = 1962), and matched controls (n = 2217). A healthy lifestyle was defined by BMI < 25 kg/m2, moderate-to-high physical activity, a healthy diet, no smoking, and moderate alcohol consumption. We estimated odds ratios (OR) with 95% confidence intervals (CIs) adjusted for age, sex, education, and FHD. Results: Compared to a poor/moderate lifestyle, a healthy lifestyle was associated with a reduced risk of LADA (OR 0.51, CI 0.34–0.77) and type 2 diabetes (OR 0.09, CI 0.05–0.15). A healthy lifestyle conferred a reduced risk irrespective of FHD and high-risk HLA genotypes. Having a BMI < 25 kg/m2 conferred the largest risk reduction for both LADA (OR 0.54, CI 0.43–0.66) and type 2 diabetes (OR 0.12, CI 0.10–0.15) out of the individual items. Conclusion: People with a healthy lifestyle, especially a healthy body weight, have a reduced risk of LADA including those with genetic susceptibility to diabetes.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Autoimmune diabetes, LADA, Lifestyle, Type 2 diabetes, ANDIS, diabetes
in
Diabetes Research and Clinical Practice
volume
174
article number
108760
publisher
Elsevier
external identifiers
  • pmid:33744376
  • scopus:85102858922
ISSN
0168-8227
DOI
10.1016/j.diabres.2021.108760
language
English
LU publication?
yes
id
0f08da2d-65ee-479f-83dc-01400ddac941
date added to LUP
2021-03-30 13:37:10
date last changed
2025-02-23 10:00:37
@article{0f08da2d-65ee-479f-83dc-01400ddac941,
  abstract     = {{<p>Aims: We investigated the risk of latent autoimmune diabetes in adults (LADA) and type 2 diabetes in relation to a healthy lifestyle, the proportion of patients attributable to an unhealthy lifestyle, and the influence of family history of diabetes (FHD) and genetic susceptibility. Methods: The population-based study included incident LADA (n = 571), type 2 diabetes (n = 1962), and matched controls (n = 2217). A healthy lifestyle was defined by BMI &lt; 25 kg/m<sup>2</sup>, moderate-to-high physical activity, a healthy diet, no smoking, and moderate alcohol consumption. We estimated odds ratios (OR) with 95% confidence intervals (CIs) adjusted for age, sex, education, and FHD. Results: Compared to a poor/moderate lifestyle, a healthy lifestyle was associated with a reduced risk of LADA (OR 0.51, CI 0.34–0.77) and type 2 diabetes (OR 0.09, CI 0.05–0.15). A healthy lifestyle conferred a reduced risk irrespective of FHD and high-risk HLA genotypes. Having a BMI &lt; 25 kg/m<sup>2</sup> conferred the largest risk reduction for both LADA (OR 0.54, CI 0.43–0.66) and type 2 diabetes (OR 0.12, CI 0.10–0.15) out of the individual items. Conclusion: People with a healthy lifestyle, especially a healthy body weight, have a reduced risk of LADA including those with genetic susceptibility to diabetes.</p>}},
  author       = {{Herzog, Katharina and Ahlqvist, Emma and Alfredsson, Lars and Groop, Leif and Hjort, Rebecka and Löfvenborg, Josefin E. and Tuomi, Tiinamaija and Carlsson, Sofia}},
  issn         = {{0168-8227}},
  keywords     = {{Autoimmune diabetes; LADA; Lifestyle; Type 2 diabetes; ANDIS; diabetes}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Diabetes Research and Clinical Practice}},
  title        = {{Combined lifestyle factors and the risk of LADA and type 2 diabetes – Results from a Swedish population-based case-control study}},
  url          = {{http://dx.doi.org/10.1016/j.diabres.2021.108760}},
  doi          = {{10.1016/j.diabres.2021.108760}},
  volume       = {{174}},
  year         = {{2021}},
}