Hepcidin discriminates sepsis from other critical illness at admission to intensive care
Olinder, Jon LU ; Börjesson, Alex ; Norrman, Jakob ; West, Tobias ; Carlström, Joakim ; Gustafsson, Alexander ; Annborn, Martin LU ; Herwald, Heiko LU
and Rydén, Cecilia
LU
(2022)
In Scientific Reports
12.
p.1-16
- Abstract
Initial differential diagnosis and prognosis for patients admitted to intensive care with suspected sepsis remain arduous. Hepcidin has emerged as a potential biomarker for sepsis. Here we report data on the relevance of levels of hepcidin versus other biomarkers as a diagnostic and prognostic tool for sepsis. 164 adult patients admitted to the intensive care unit (ICU) within 24 h upon arrival to the hospital were included. Blood samples collected daily for seven consecutive days and hepcidin levels, heparin binding protein (HBP) levels and standard biomarkers were determined. Blood cultures were initiated at inclusion. Clinical scores were evaluated daily and mortality after 28- and 180-days was recorded. One hundred of the patients... (More)
Initial differential diagnosis and prognosis for patients admitted to intensive care with suspected sepsis remain arduous. Hepcidin has emerged as a potential biomarker for sepsis. Here we report data on the relevance of levels of hepcidin versus other biomarkers as a diagnostic and prognostic tool for sepsis. 164 adult patients admitted to the intensive care unit (ICU) within 24 h upon arrival to the hospital were included. Blood samples collected daily for seven consecutive days and hepcidin levels, heparin binding protein (HBP) levels and standard biomarkers were determined. Blood cultures were initiated at inclusion. Clinical scores were evaluated daily and mortality after 28- and 180-days was recorded. One hundred of the patients were found to fulfil the criteria for sepsis whereas 64 did not. Hepcidin levels at admission were significantly higher in the septic than in the non-septic patients. In septic patients hepcidin levels declined significantly already at 24 h followed by a steady decline. A significant negative correlation was observed between hepcidin levels and SAPS 3 in patients with sepsis. Hepcidin levels at inclusion were significantly higher among septic patients that survived 180-days and predicted mortality. Our data show that hepcidin levels are indicative of sepsis in patients admitted to the ICU and has a prognostic value for mortality.
(Less)
- author
- Olinder, Jon
LU
; Börjesson, Alex
; Norrman, Jakob
; West, Tobias
; Carlström, Joakim
; Gustafsson, Alexander
; Annborn, Martin
LU
; Herwald, Heiko
LU
and Rydén, Cecilia
LU
- organization
- publishing date
- 2022-09-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scientific Reports
- volume
- 12
- article number
- 14857
- pages
- 1 - 16
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:36050405
- scopus:85137120149
- ISSN
- 2045-2322
- DOI
- 10.1038/s41598-022-18826-0
- language
- English
- LU publication?
- yes
- additional info
- © 2022. The Author(s).
- id
- 0f4489f6-6fce-46e4-8e73-d6f5c6cc9010
- date added to LUP
- 2022-09-05 08:42:29
- date last changed
- 2024-06-13 14:40:58
@article{0f4489f6-6fce-46e4-8e73-d6f5c6cc9010,
abstract = {{<p>Initial differential diagnosis and prognosis for patients admitted to intensive care with suspected sepsis remain arduous. Hepcidin has emerged as a potential biomarker for sepsis. Here we report data on the relevance of levels of hepcidin versus other biomarkers as a diagnostic and prognostic tool for sepsis. 164 adult patients admitted to the intensive care unit (ICU) within 24 h upon arrival to the hospital were included. Blood samples collected daily for seven consecutive days and hepcidin levels, heparin binding protein (HBP) levels and standard biomarkers were determined. Blood cultures were initiated at inclusion. Clinical scores were evaluated daily and mortality after 28- and 180-days was recorded. One hundred of the patients were found to fulfil the criteria for sepsis whereas 64 did not. Hepcidin levels at admission were significantly higher in the septic than in the non-septic patients. In septic patients hepcidin levels declined significantly already at 24 h followed by a steady decline. A significant negative correlation was observed between hepcidin levels and SAPS 3 in patients with sepsis. Hepcidin levels at inclusion were significantly higher among septic patients that survived 180-days and predicted mortality. Our data show that hepcidin levels are indicative of sepsis in patients admitted to the ICU and has a prognostic value for mortality.</p>}},
author = {{Olinder, Jon and Börjesson, Alex and Norrman, Jakob and West, Tobias and Carlström, Joakim and Gustafsson, Alexander and Annborn, Martin and Herwald, Heiko and Rydén, Cecilia}},
issn = {{2045-2322}},
language = {{eng}},
month = {{09}},
pages = {{1--16}},
publisher = {{Nature Publishing Group}},
series = {{Scientific Reports}},
title = {{Hepcidin discriminates sepsis from other critical illness at admission to intensive care}},
url = {{http://dx.doi.org/10.1038/s41598-022-18826-0}},
doi = {{10.1038/s41598-022-18826-0}},
volume = {{12}},
year = {{2022}},
}