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Molecular information on the dissolution of polydisperse polymers: Mixtures of long and short poly(ethylene oxide)

Körner, Anna LU ; Larsson, A ; Piculell, Lennart LU and Wittgren, B (2005) In The Journal of Physical Chemistry Part B 109(23). p.11530-11537
Abstract
A systematic study of the dissolution of dry, polydisperse polyethylene oxide) (PEO) samples, obtained from mixtures of low-molecular-weight and high-molecular-weight PEO, was made. During the dissolution process, the individual release of the low-and high-molecular-weight fractions was monitored. The highmolecular-weight/low-molecular-weight ratio controls the release rate, and the fraction of high-molecular-weight polymers dominates the effect on the overall release rate in mixed PEO tablets. Both fractions are released at the same rate during the main part of the dissolution process; however, during the initial dissolution period a fractionation occurs. The release rate is not a unique function of the average molecular weight of the... (More)
A systematic study of the dissolution of dry, polydisperse polyethylene oxide) (PEO) samples, obtained from mixtures of low-molecular-weight and high-molecular-weight PEO, was made. During the dissolution process, the individual release of the low-and high-molecular-weight fractions was monitored. The highmolecular-weight/low-molecular-weight ratio controls the release rate, and the fraction of high-molecular-weight polymers dominates the effect on the overall release rate in mixed PEO tablets. Both fractions are released at the same rate during the main part of the dissolution process; however, during the initial dissolution period a fractionation occurs. The release rate is not a unique function of the average molecular weight of the polymer, but also depends on the polydispersity. By contrast, the average dimension of a polymer coil, as given by the intrinsic viscosity, gives a good prediction of the release rate irrespective of the polydispersity or details of the molecular weight distribution. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The Journal of Physical Chemistry Part B
volume
109
issue
23
pages
11530 - 11537
publisher
The American Chemical Society (ACS)
external identifiers
  • wos:000229751800020
  • scopus:21644452768
ISSN
1520-5207
DOI
10.1021/jp044332s
language
English
LU publication?
yes
id
0f539163-297f-4759-9f1f-c23633dc8b9b (old id 157428)
date added to LUP
2016-04-01 15:33:56
date last changed
2022-03-07 00:14:16
@article{0f539163-297f-4759-9f1f-c23633dc8b9b,
  abstract     = {{A systematic study of the dissolution of dry, polydisperse polyethylene oxide) (PEO) samples, obtained from mixtures of low-molecular-weight and high-molecular-weight PEO, was made. During the dissolution process, the individual release of the low-and high-molecular-weight fractions was monitored. The highmolecular-weight/low-molecular-weight ratio controls the release rate, and the fraction of high-molecular-weight polymers dominates the effect on the overall release rate in mixed PEO tablets. Both fractions are released at the same rate during the main part of the dissolution process; however, during the initial dissolution period a fractionation occurs. The release rate is not a unique function of the average molecular weight of the polymer, but also depends on the polydispersity. By contrast, the average dimension of a polymer coil, as given by the intrinsic viscosity, gives a good prediction of the release rate irrespective of the polydispersity or details of the molecular weight distribution.}},
  author       = {{Körner, Anna and Larsson, A and Piculell, Lennart and Wittgren, B}},
  issn         = {{1520-5207}},
  language     = {{eng}},
  number       = {{23}},
  pages        = {{11530--11537}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{The Journal of Physical Chemistry Part B}},
  title        = {{Molecular information on the dissolution of polydisperse polymers: Mixtures of long and short poly(ethylene oxide)}},
  url          = {{http://dx.doi.org/10.1021/jp044332s}},
  doi          = {{10.1021/jp044332s}},
  volume       = {{109}},
  year         = {{2005}},
}