Molecular information on the dissolution of polydisperse polymers: Mixtures of long and short poly(ethylene oxide)
(2005) In The Journal of Physical Chemistry Part B 109(23). p.11530-11537- Abstract
- A systematic study of the dissolution of dry, polydisperse polyethylene oxide) (PEO) samples, obtained from mixtures of low-molecular-weight and high-molecular-weight PEO, was made. During the dissolution process, the individual release of the low-and high-molecular-weight fractions was monitored. The highmolecular-weight/low-molecular-weight ratio controls the release rate, and the fraction of high-molecular-weight polymers dominates the effect on the overall release rate in mixed PEO tablets. Both fractions are released at the same rate during the main part of the dissolution process; however, during the initial dissolution period a fractionation occurs. The release rate is not a unique function of the average molecular weight of the... (More)
- A systematic study of the dissolution of dry, polydisperse polyethylene oxide) (PEO) samples, obtained from mixtures of low-molecular-weight and high-molecular-weight PEO, was made. During the dissolution process, the individual release of the low-and high-molecular-weight fractions was monitored. The highmolecular-weight/low-molecular-weight ratio controls the release rate, and the fraction of high-molecular-weight polymers dominates the effect on the overall release rate in mixed PEO tablets. Both fractions are released at the same rate during the main part of the dissolution process; however, during the initial dissolution period a fractionation occurs. The release rate is not a unique function of the average molecular weight of the polymer, but also depends on the polydispersity. By contrast, the average dimension of a polymer coil, as given by the intrinsic viscosity, gives a good prediction of the release rate irrespective of the polydispersity or details of the molecular weight distribution. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/157428
- author
- Körner, Anna LU ; Larsson, A ; Piculell, Lennart LU and Wittgren, B
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The Journal of Physical Chemistry Part B
- volume
- 109
- issue
- 23
- pages
- 11530 - 11537
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- wos:000229751800020
- scopus:21644452768
- ISSN
- 1520-5207
- DOI
- 10.1021/jp044332s
- language
- English
- LU publication?
- yes
- id
- 0f539163-297f-4759-9f1f-c23633dc8b9b (old id 157428)
- date added to LUP
- 2016-04-01 15:33:56
- date last changed
- 2022-03-07 00:14:16
@article{0f539163-297f-4759-9f1f-c23633dc8b9b, abstract = {{A systematic study of the dissolution of dry, polydisperse polyethylene oxide) (PEO) samples, obtained from mixtures of low-molecular-weight and high-molecular-weight PEO, was made. During the dissolution process, the individual release of the low-and high-molecular-weight fractions was monitored. The highmolecular-weight/low-molecular-weight ratio controls the release rate, and the fraction of high-molecular-weight polymers dominates the effect on the overall release rate in mixed PEO tablets. Both fractions are released at the same rate during the main part of the dissolution process; however, during the initial dissolution period a fractionation occurs. The release rate is not a unique function of the average molecular weight of the polymer, but also depends on the polydispersity. By contrast, the average dimension of a polymer coil, as given by the intrinsic viscosity, gives a good prediction of the release rate irrespective of the polydispersity or details of the molecular weight distribution.}}, author = {{Körner, Anna and Larsson, A and Piculell, Lennart and Wittgren, B}}, issn = {{1520-5207}}, language = {{eng}}, number = {{23}}, pages = {{11530--11537}}, publisher = {{The American Chemical Society (ACS)}}, series = {{The Journal of Physical Chemistry Part B}}, title = {{Molecular information on the dissolution of polydisperse polymers: Mixtures of long and short poly(ethylene oxide)}}, url = {{http://dx.doi.org/10.1021/jp044332s}}, doi = {{10.1021/jp044332s}}, volume = {{109}}, year = {{2005}}, }