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Intra-tumour IgA1 is common in cancer and is correlated with poor prognosis in bladder cancer.

Welinder, Charlotte LU ; Jirström, Karin LU orcid ; Lehn, Sophie LU ; Nodin, Björn LU ; Marko-Varga, György LU ; Blixt, Ola ; Danielsson, Lena LU and Jansson, Bo LU (2016) In Heliyon 2(8).
Abstract

A high frequency of IgA1-positive tumour cells was found in tissue micro-arrays of oesophagus, colon, testis, lung, breast, bladder and ovarian cancer. IgA1 was observed in the cytoplasm and the plasma membrane. A correlation was found between intra-tumour IgA1 and poor overall survival in a large cohort of bladder cancer patients (n = 99, p = 0.011, log-rank test). The number of IgA1-positive tumour cells was also found to be higher in female than male bladder cancer patients. The presence of IgA1 was confirmed in formalin-fixed paraffin-embedded ovarian carcinoma samples using LC-MS/MS analysis. Uptake of IgA1 was also observed in breast cancer and melanoma cell lines when cultivated in the presence of serum from healthy individuals,... (More)

A high frequency of IgA1-positive tumour cells was found in tissue micro-arrays of oesophagus, colon, testis, lung, breast, bladder and ovarian cancer. IgA1 was observed in the cytoplasm and the plasma membrane. A correlation was found between intra-tumour IgA1 and poor overall survival in a large cohort of bladder cancer patients (n = 99, p = 0.011, log-rank test). The number of IgA1-positive tumour cells was also found to be higher in female than male bladder cancer patients. The presence of IgA1 was confirmed in formalin-fixed paraffin-embedded ovarian carcinoma samples using LC-MS/MS analysis. Uptake of IgA1 was also observed in breast cancer and melanoma cell lines when cultivated in the presence of serum from healthy individuals, indicating a possible origin of the IgA1 antibodies in cancer cells.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Medicine
in
Heliyon
volume
2
issue
8
article number
e00143
publisher
Elsevier
external identifiers
  • pmid:27579449
  • scopus:84989232417
ISSN
2405-8440
DOI
10.1016/j.heliyon.2016.e00143
language
English
LU publication?
yes
id
0f6f9126-bf15-4a91-8859-a335f75ec95a
date added to LUP
2017-02-16 15:45:06
date last changed
2025-01-21 10:58:56
@article{0f6f9126-bf15-4a91-8859-a335f75ec95a,
  abstract     = {{<p>A high frequency of IgA1-positive tumour cells was found in tissue micro-arrays of oesophagus, colon, testis, lung, breast, bladder and ovarian cancer. IgA1 was observed in the cytoplasm and the plasma membrane. A correlation was found between intra-tumour IgA1 and poor overall survival in a large cohort of bladder cancer patients (n = 99, p = 0.011, log-rank test). The number of IgA1-positive tumour cells was also found to be higher in female than male bladder cancer patients. The presence of IgA1 was confirmed in formalin-fixed paraffin-embedded ovarian carcinoma samples using LC-MS/MS analysis. Uptake of IgA1 was also observed in breast cancer and melanoma cell lines when cultivated in the presence of serum from healthy individuals, indicating a possible origin of the IgA1 antibodies in cancer cells.</p>}},
  author       = {{Welinder, Charlotte and Jirström, Karin and Lehn, Sophie and Nodin, Björn and Marko-Varga, György and Blixt, Ola and Danielsson, Lena and Jansson, Bo}},
  issn         = {{2405-8440}},
  keywords     = {{Medicine}},
  language     = {{eng}},
  number       = {{8}},
  publisher    = {{Elsevier}},
  series       = {{Heliyon}},
  title        = {{Intra-tumour IgA1 is common in cancer and is correlated with poor prognosis in bladder cancer.}},
  url          = {{http://dx.doi.org/10.1016/j.heliyon.2016.e00143}},
  doi          = {{10.1016/j.heliyon.2016.e00143}},
  volume       = {{2}},
  year         = {{2016}},
}