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The integrin-mediated adhesive complex in the ancestor of animals, fungi, and amoebae

Kang, Seungho ; Tice, Alexander K. ; Stairs, Courtney W. LU orcid ; Jones, Robert E. ; Lahr, Daniel J.G. and Brown, Matthew W. (2021) In Current Biology 31(14). p.3-3085
Abstract

Integrins are transmembrane receptors that activate signal transduction pathways upon extracellular matrix binding. The integrin-mediated adhesive complex (IMAC) mediates various cell physiological processes. Although the IMAC was thought to be specific to animals, in the past ten years these complexes were discovered in other lineages of Obazoa, the group containing animals, fungi, and several microbial eukaryotes. Very recently, many genomes and transcriptomes from Amoebozoa (the eukaryotic supergroup sister to Obazoa), other obazoans, orphan protist lineages, and the eukaryotes’ closest prokaryotic relatives, have become available. To increase the resolution of where and when IMAC proteins exist and have emerged, we surveyed these... (More)

Integrins are transmembrane receptors that activate signal transduction pathways upon extracellular matrix binding. The integrin-mediated adhesive complex (IMAC) mediates various cell physiological processes. Although the IMAC was thought to be specific to animals, in the past ten years these complexes were discovered in other lineages of Obazoa, the group containing animals, fungi, and several microbial eukaryotes. Very recently, many genomes and transcriptomes from Amoebozoa (the eukaryotic supergroup sister to Obazoa), other obazoans, orphan protist lineages, and the eukaryotes’ closest prokaryotic relatives, have become available. To increase the resolution of where and when IMAC proteins exist and have emerged, we surveyed these newly available genomes and transcriptomes for the presence of IMAC proteins. Our results highlight that many of these proteins appear to have evolved earlier in eukaryote evolution than previously thought and that co-option of this apparently ancient protein complex was key to the emergence of animal-type multicellularity. The role of the IMACs in amoebozoans is unknown, but they play critical adhesive roles in at least some unicellular organisms.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
amoeba, Amoebozoa, integrin, Obazoa, Opisthokonta, protein domain architecture, reductive evolution
in
Current Biology
volume
31
issue
14
pages
3 - 3085
publisher
Elsevier
external identifiers
  • scopus:85111009759
  • pmid:34077702
ISSN
0960-9822
DOI
10.1016/j.cub.2021.04.076
language
English
LU publication?
yes
additional info
Funding Information: This project was supported in part by US National Science Foundation (NSF), Division of Environmental Biology (DEB) grants 1456054 and 2100888 ( https://www.nsf.gov/ ), awarded to M.W.B. We thank Prof. Andrew J. Roger (Dalhousie University) for advanced access to Mastigamoeba balamuthi transcriptome, which was supported by grant MOP-142349 from the Canadian Institutes of Health Research , awarded to A.J. Roger. We thank the anonymous reviewers for the constructive criticism and helpful comments, leading to a better manuscript. Publisher Copyright: © 2021 Elsevier Inc. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
id
0f8590c6-25be-4fff-9e3a-d3b7adce3343
date added to LUP
2021-08-11 10:43:09
date last changed
2024-06-15 14:03:51
@article{0f8590c6-25be-4fff-9e3a-d3b7adce3343,
  abstract     = {{<p>Integrins are transmembrane receptors that activate signal transduction pathways upon extracellular matrix binding. The integrin-mediated adhesive complex (IMAC) mediates various cell physiological processes. Although the IMAC was thought to be specific to animals, in the past ten years these complexes were discovered in other lineages of Obazoa, the group containing animals, fungi, and several microbial eukaryotes. Very recently, many genomes and transcriptomes from Amoebozoa (the eukaryotic supergroup sister to Obazoa), other obazoans, orphan protist lineages, and the eukaryotes’ closest prokaryotic relatives, have become available. To increase the resolution of where and when IMAC proteins exist and have emerged, we surveyed these newly available genomes and transcriptomes for the presence of IMAC proteins. Our results highlight that many of these proteins appear to have evolved earlier in eukaryote evolution than previously thought and that co-option of this apparently ancient protein complex was key to the emergence of animal-type multicellularity. The role of the IMACs in amoebozoans is unknown, but they play critical adhesive roles in at least some unicellular organisms.</p>}},
  author       = {{Kang, Seungho and Tice, Alexander K. and Stairs, Courtney W. and Jones, Robert E. and Lahr, Daniel J.G. and Brown, Matthew W.}},
  issn         = {{0960-9822}},
  keywords     = {{amoeba; Amoebozoa; integrin; Obazoa; Opisthokonta; protein domain architecture; reductive evolution}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{14}},
  pages        = {{3--3085}},
  publisher    = {{Elsevier}},
  series       = {{Current Biology}},
  title        = {{The integrin-mediated adhesive complex in the ancestor of animals, fungi, and amoebae}},
  url          = {{http://dx.doi.org/10.1016/j.cub.2021.04.076}},
  doi          = {{10.1016/j.cub.2021.04.076}},
  volume       = {{31}},
  year         = {{2021}},
}