Positional cloning of ncf1- a piece in the puzzle of arthritis genetics.
(2003) In Scandinavian Journal of Immunology 58(2). p.155-164- Abstract
- Positional cloning of susceptibility genes in complex diseases like rheumatoid arthritis in humans is hampered by aspects like genetic heterogeneity and environmental variations, while genetic studies in animal models contain several advantages. With animal models, the environment can be controlled, the genetic complexity of the disease is minimized and the disease onset can be predicted, which simplify diagnosis and characterization. We use pristane-induced arthritis in rats to investigate the inheritance of arthritis. Until now, we have identified 15 loci that significantly predispose rats to the development of arthritis. One of these arthritis loci has been isolated and confirmed to be caused by a polymorphism in the Ncf1 gene. In this... (More)
- Positional cloning of susceptibility genes in complex diseases like rheumatoid arthritis in humans is hampered by aspects like genetic heterogeneity and environmental variations, while genetic studies in animal models contain several advantages. With animal models, the environment can be controlled, the genetic complexity of the disease is minimized and the disease onset can be predicted, which simplify diagnosis and characterization. We use pristane-induced arthritis in rats to investigate the inheritance of arthritis. Until now, we have identified 15 loci that significantly predispose rats to the development of arthritis. One of these arthritis loci has been isolated and confirmed to be caused by a polymorphism in the Ncf1 gene. In this review, we outline the methods used to identify Ncf1 as one single susceptibility gene in a complex puzzle of inherited factors that render susceptibility to a complex autoimmune disorder like arthritis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/116456
- author
- Olofsson, Peter LU and Holmdahl, Rikard LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scandinavian Journal of Immunology
- volume
- 58
- issue
- 2
- pages
- 155 - 164
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:12869136
- wos:000184268800005
- scopus:0041846819
- ISSN
- 1365-3083
- DOI
- 10.1046/j.1365-3083.2003.01293.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Medical Inflammation Research (013212019)
- id
- 0f86df60-ac68-4aac-a7a2-446c16b1dfed (old id 116456)
- date added to LUP
- 2016-04-01 15:23:38
- date last changed
- 2022-01-28 05:05:15
@article{0f86df60-ac68-4aac-a7a2-446c16b1dfed,
abstract = {{Positional cloning of susceptibility genes in complex diseases like rheumatoid arthritis in humans is hampered by aspects like genetic heterogeneity and environmental variations, while genetic studies in animal models contain several advantages. With animal models, the environment can be controlled, the genetic complexity of the disease is minimized and the disease onset can be predicted, which simplify diagnosis and characterization. We use pristane-induced arthritis in rats to investigate the inheritance of arthritis. Until now, we have identified 15 loci that significantly predispose rats to the development of arthritis. One of these arthritis loci has been isolated and confirmed to be caused by a polymorphism in the Ncf1 gene. In this review, we outline the methods used to identify Ncf1 as one single susceptibility gene in a complex puzzle of inherited factors that render susceptibility to a complex autoimmune disorder like arthritis.}},
author = {{Olofsson, Peter and Holmdahl, Rikard}},
issn = {{1365-3083}},
language = {{eng}},
number = {{2}},
pages = {{155--164}},
publisher = {{Wiley-Blackwell}},
series = {{Scandinavian Journal of Immunology}},
title = {{Positional cloning of ncf1- a piece in the puzzle of arthritis genetics.}},
url = {{https://lup.lub.lu.se/search/files/4382703/623836.pdf}},
doi = {{10.1046/j.1365-3083.2003.01293.x}},
volume = {{58}},
year = {{2003}},
}