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Aortic diameter at age 65 in men with newly diagnosed type 2 diabetes

Taimour, Soumia LU ; Zarrouk, Moncef LU ; Holst, Jan LU ; Rosengren, Anders H. LU ; Groop, Leif LU ; Nilsson, Peter M. LU and Gottsäter, Anders LU (2017) In Scandinavian Cardiovascular Journal 51(4). p.202-206
Abstract

Objectives. Type 2 diabetes mellitus has been linked to a decreased risk for abdominal aortic aneurysm (aortic diameter ≥30 mm, AAA) development in men. The aim of this study was to evaluate if such an effect is detectable already around the time of diabetes diagnosis. Design. We cross-sectionally compared aortic diameter at ultrasound screening for AAA in 691 men aged 65 years with incipient or newly diagnosed type 2 diabetes (group A) with 18,262 65-year old control men without diabetes (group B). Results. Aortic diameter did not differ between groups (18.8[17.4–20.8] vs. 19.0[17.5–28.7] mm; p = 0.43). AAA prevalence was 2.5% in group A and 1.5% in group B (p = .010). In logistic regression taking group differences in body mass index... (More)

Objectives. Type 2 diabetes mellitus has been linked to a decreased risk for abdominal aortic aneurysm (aortic diameter ≥30 mm, AAA) development in men. The aim of this study was to evaluate if such an effect is detectable already around the time of diabetes diagnosis. Design. We cross-sectionally compared aortic diameter at ultrasound screening for AAA in 691 men aged 65 years with incipient or newly diagnosed type 2 diabetes (group A) with 18,262 65-year old control men without diabetes (group B). Results. Aortic diameter did not differ between groups (18.8[17.4–20.8] vs. 19.0[17.5–28.7] mm; p = 0.43). AAA prevalence was 2.5% in group A and 1.5% in group B (p = .010). In logistic regression taking group differences in body mass index (BMI), smoking, presence of atherosclerotic disease and hypertension into account, the difference in AAA prevalence was no longer significant (p = .15). Among men in group A, C-peptide (r = .093; p = .034), but not HbA1c (r = .060; p = .24) correlated with aortic diameter. Conclusion. Among 65 year old men aortic diameter and AAA prevalence do not differ between those with newly diagnosed type 2 diabetes and those without diabetes. Putative protective effects of type 2 diabetes mellitus against aortic dilatation and AAA development therefore probably occur later after diagnosis of diabetes.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Abdominal aortic aneurysm, aortic diameter, screening, type 2 diabetes, ultrasound
in
Scandinavian Cardiovascular Journal
volume
51
issue
4
pages
5 pages
publisher
Taylor & Francis
external identifiers
  • pmid:28434285
  • wos:000403153300004
  • scopus:85018829578
ISSN
1401-7431
DOI
10.1080/14017431.2017.1319971
language
English
LU publication?
yes
id
0f9e9acd-8d25-4d31-adf3-eb310147ebd5
date added to LUP
2017-05-29 11:14:32
date last changed
2025-01-07 14:20:39
@article{0f9e9acd-8d25-4d31-adf3-eb310147ebd5,
  abstract     = {{<p>Objectives. Type 2 diabetes mellitus has been linked to a decreased risk for abdominal aortic aneurysm (aortic diameter ≥30 mm, AAA) development in men. The aim of this study was to evaluate if such an effect is detectable already around the time of diabetes diagnosis. Design. We cross-sectionally compared aortic diameter at ultrasound screening for AAA in 691 men aged 65 years with incipient or newly diagnosed type 2 diabetes (group A) with 18,262 65-year old control men without diabetes (group B). Results. Aortic diameter did not differ between groups (18.8[17.4–20.8] vs. 19.0[17.5–28.7] mm; p = 0.43). AAA prevalence was 2.5% in group A and 1.5% in group B (p = .010). In logistic regression taking group differences in body mass index (BMI), smoking, presence of atherosclerotic disease and hypertension into account, the difference in AAA prevalence was no longer significant (p = .15). Among men in group A, C-peptide (r = .093; p = .034), but not HbA1c (r = .060; p = .24) correlated with aortic diameter. Conclusion. Among 65 year old men aortic diameter and AAA prevalence do not differ between those with newly diagnosed type 2 diabetes and those without diabetes. Putative protective effects of type 2 diabetes mellitus against aortic dilatation and AAA development therefore probably occur later after diagnosis of diabetes.</p>}},
  author       = {{Taimour, Soumia and Zarrouk, Moncef and Holst, Jan and Rosengren, Anders H. and Groop, Leif and Nilsson, Peter M. and Gottsäter, Anders}},
  issn         = {{1401-7431}},
  keywords     = {{Abdominal aortic aneurysm; aortic diameter; screening; type 2 diabetes; ultrasound}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{4}},
  pages        = {{202--206}},
  publisher    = {{Taylor & Francis}},
  series       = {{Scandinavian Cardiovascular Journal}},
  title        = {{Aortic diameter at age 65 in men with newly diagnosed type 2 diabetes}},
  url          = {{http://dx.doi.org/10.1080/14017431.2017.1319971}},
  doi          = {{10.1080/14017431.2017.1319971}},
  volume       = {{51}},
  year         = {{2017}},
}