Measurement Techniques for Respiratory Tract Deposition of Airborne Nanoparticles: A Critical Review.
Löndahl, Jakob LU
; Möller, Winfried
; Pagels, Joakim
LU
; Kreyling, Wolfgang G
; Swietlicki, Erik
LU
and Schmid, Otmar
(2014)
In Journal of Aerosol Medicine and Pulmonary Drug Delivery
27(4).
p.229-254
- Abstract
- Abstract Determination of the respiratory tract deposition of airborne particles is critical for risk assessment of air pollution, inhaled drug delivery, and understanding of respiratory disease. With the advent of nanotechnology, there has been an increasing interest in the measurement of pulmonary deposition of nanoparticles because of their unique properties in inhalation toxicology and medicine. Over the last century, around 50 studies have presented experimental data on lung deposition of nanoparticles (typical diameter≤100 nm, but here≤300 nm). These data show a considerable variability, partly due to differences in the applied methodologies. In this study, we review the experimental techniques for measuring respiratory tract... (More)
- Abstract Determination of the respiratory tract deposition of airborne particles is critical for risk assessment of air pollution, inhaled drug delivery, and understanding of respiratory disease. With the advent of nanotechnology, there has been an increasing interest in the measurement of pulmonary deposition of nanoparticles because of their unique properties in inhalation toxicology and medicine. Over the last century, around 50 studies have presented experimental data on lung deposition of nanoparticles (typical diameter≤100 nm, but here≤300 nm). These data show a considerable variability, partly due to differences in the applied methodologies. In this study, we review the experimental techniques for measuring respiratory tract deposition of nano-sized particles, analyze critical experimental design aspects causing measurement uncertainties, and suggest methodologies for future studies. It is shown that, although particle detection techniques have developed with time, the overall methodology in respiratory tract deposition experiments has not seen similar progress. Available experience from previous research has often not been incorporated, and some methodological design aspects that were overlooked in 30-70% of all studies may have biased the experimental data. This has contributed to a significant uncertainty on the absolute value of the lung deposition fraction of nanoparticles. We estimate the impact of the design aspects on obtained data, discuss solutions to minimize errors, and highlight gaps in the available experimental set of data. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4143063
- author
- Löndahl, Jakob
LU
; Möller, Winfried
; Pagels, Joakim
LU
; Kreyling, Wolfgang G
; Swietlicki, Erik
LU
and Schmid, Otmar
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- aerosol, engineered nanoparticles, dosimetry, health, inhalation, NSAM, ultrafine particles, pulmonary, lung deposition
- in
- Journal of Aerosol Medicine and Pulmonary Drug Delivery
- volume
- 27
- issue
- 4
- pages
- 229 - 254
- publisher
- Mary Ann Liebert, Inc.
- external identifiers
-
- pmid:24151837
- wos:000340520400082
- scopus:84905443848
- ISSN
- 1941-2703
- DOI
- 10.1089/jamp.2013.1044
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Nuclear Physics (Faculty of Technology) (011013007), Ergonomics and Aerosol Technology (011025002)
- id
- 0faba5ba-7ae3-466b-8da0-feb9c5b22c8d (old id 4143063)
- date added to LUP
- 2016-04-01 10:46:20
- date last changed
- 2023-11-10 04:38:20
@article{0faba5ba-7ae3-466b-8da0-feb9c5b22c8d,
abstract = {{Abstract Determination of the respiratory tract deposition of airborne particles is critical for risk assessment of air pollution, inhaled drug delivery, and understanding of respiratory disease. With the advent of nanotechnology, there has been an increasing interest in the measurement of pulmonary deposition of nanoparticles because of their unique properties in inhalation toxicology and medicine. Over the last century, around 50 studies have presented experimental data on lung deposition of nanoparticles (typical diameter≤100 nm, but here≤300 nm). These data show a considerable variability, partly due to differences in the applied methodologies. In this study, we review the experimental techniques for measuring respiratory tract deposition of nano-sized particles, analyze critical experimental design aspects causing measurement uncertainties, and suggest methodologies for future studies. It is shown that, although particle detection techniques have developed with time, the overall methodology in respiratory tract deposition experiments has not seen similar progress. Available experience from previous research has often not been incorporated, and some methodological design aspects that were overlooked in 30-70% of all studies may have biased the experimental data. This has contributed to a significant uncertainty on the absolute value of the lung deposition fraction of nanoparticles. We estimate the impact of the design aspects on obtained data, discuss solutions to minimize errors, and highlight gaps in the available experimental set of data.}},
author = {{Löndahl, Jakob and Möller, Winfried and Pagels, Joakim and Kreyling, Wolfgang G and Swietlicki, Erik and Schmid, Otmar}},
issn = {{1941-2703}},
keywords = {{aerosol; engineered nanoparticles; dosimetry; health; inhalation; NSAM; ultrafine particles; pulmonary; lung deposition}},
language = {{eng}},
number = {{4}},
pages = {{229--254}},
publisher = {{Mary Ann Liebert, Inc.}},
series = {{Journal of Aerosol Medicine and Pulmonary Drug Delivery}},
title = {{Measurement Techniques for Respiratory Tract Deposition of Airborne Nanoparticles: A Critical Review.}},
url = {{https://lup.lub.lu.se/search/files/2119137/4457812.pdf}},
doi = {{10.1089/jamp.2013.1044}},
volume = {{27}},
year = {{2014}},
}