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Contractile properties of lymphatics from the human lower leg

Sjöberg, Trygve LU and Steen, Stig LU (1991) In Lymphology 24(1). p.16-21
Abstract
Lower leg lymphatics, taken from seven volunteers, were investigated in vitro. Isometric contractions were induced by noradrenaline, 5-hydroxytryptamine (5-HT), prostaglandin F2 alpha (PGF2 alpha), and the thromboxane A2 (TXA2)-mimetic U-44069. Noradrenaline induced phasic contractions in 6 of 7 segments. The amplitude of the contractions were up to 100% of a previous K+ (124mM)-induced contraction and the frequency at 10(-6)M of noradrenaline was 5-13 min-1. These contractions were unaffected by propranolol (10(-6)M), but they were abolished by phentolamine (10(-6)M). Noradrenaline had an Emax (tonic contraction) of 7% of the K+ (124mM) contraction (n = 7) and the pEC50-value was 6.9 (n = 3). The corresponding values for 5-HT were 21% (n... (More)
Lower leg lymphatics, taken from seven volunteers, were investigated in vitro. Isometric contractions were induced by noradrenaline, 5-hydroxytryptamine (5-HT), prostaglandin F2 alpha (PGF2 alpha), and the thromboxane A2 (TXA2)-mimetic U-44069. Noradrenaline induced phasic contractions in 6 of 7 segments. The amplitude of the contractions were up to 100% of a previous K+ (124mM)-induced contraction and the frequency at 10(-6)M of noradrenaline was 5-13 min-1. These contractions were unaffected by propranolol (10(-6)M), but they were abolished by phentolamine (10(-6)M). Noradrenaline had an Emax (tonic contraction) of 7% of the K+ (124mM) contraction (n = 7) and the pEC50-value was 6.9 (n = 3). The corresponding values for 5-HT were 21% (n = 5) and 6.4 (n = 3). PGF2 alpha elicited contractions in all segments investigated (Emax = 87%, pEC50 = 5.8, n = 5). U-44069 had high contractile capacity and potency in all investigated segments (Emax = 137%, pEC50 = 8.9, n = 7). Phasic contractions were elicited also by 5-HT, PGF2 alpha and U-44069. Compared to earlier studies of human peripheral lymphatics, these results show that there are regional differences in susceptibility to these vasoactive agents. (Less)
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author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Lymphology
volume
24
issue
1
pages
16 - 21
publisher
International Society of Lymphology
external identifiers
  • pmid:1646914
  • scopus:0025906826
ISSN
0024-7766
language
English
LU publication?
yes
id
0fea5719-cc69-4736-8dca-dbad236d34eb (old id 1106079)
date added to LUP
2016-04-01 16:38:09
date last changed
2021-09-26 03:20:26
@article{0fea5719-cc69-4736-8dca-dbad236d34eb,
  abstract     = {{Lower leg lymphatics, taken from seven volunteers, were investigated in vitro. Isometric contractions were induced by noradrenaline, 5-hydroxytryptamine (5-HT), prostaglandin F2 alpha (PGF2 alpha), and the thromboxane A2 (TXA2)-mimetic U-44069. Noradrenaline induced phasic contractions in 6 of 7 segments. The amplitude of the contractions were up to 100% of a previous K+ (124mM)-induced contraction and the frequency at 10(-6)M of noradrenaline was 5-13 min-1. These contractions were unaffected by propranolol (10(-6)M), but they were abolished by phentolamine (10(-6)M). Noradrenaline had an Emax (tonic contraction) of 7% of the K+ (124mM) contraction (n = 7) and the pEC50-value was 6.9 (n = 3). The corresponding values for 5-HT were 21% (n = 5) and 6.4 (n = 3). PGF2 alpha elicited contractions in all segments investigated (Emax = 87%, pEC50 = 5.8, n = 5). U-44069 had high contractile capacity and potency in all investigated segments (Emax = 137%, pEC50 = 8.9, n = 7). Phasic contractions were elicited also by 5-HT, PGF2 alpha and U-44069. Compared to earlier studies of human peripheral lymphatics, these results show that there are regional differences in susceptibility to these vasoactive agents.}},
  author       = {{Sjöberg, Trygve and Steen, Stig}},
  issn         = {{0024-7766}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{16--21}},
  publisher    = {{International Society of Lymphology}},
  series       = {{Lymphology}},
  title        = {{Contractile properties of lymphatics from the human lower leg}},
  volume       = {{24}},
  year         = {{1991}},
}