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No detection of SV40 DNA in mesothelioma tissues from a high incidence area in Sweden.

Lundstig, Annika LU ; Dejmek, Annika LU ; Eklund, Carina LU ; Filinic, Ivo and Dillner, Joakim LU (2007) In Anticancer Research 27(6B). p.4159-4161
Abstract
Simian virus 40 (SV40), a polyoma virus of the rhesus macaque was discovered in 1960 as a contaminant of human polio vaccines produced in monkey cells. A number of studies have reported the detection of SV40 nucleotide sequences in human tumors, mainly mesotheliomas, but the reports have not been consistent. The presence of SV40 in 26 consecutive cases of malignant mesothelioma of biphasic type was investigated using a SV40 quantitative real time polymerase chain reaction (PCR) with a sensitivity of 10 copies of viral DNA per sample. All the samples were also tested for amplifiability using a real-time PCR for the beta-globin gene. Eighteen tumors were amplifiable, but none contained SV40 DNA. The results do not support an association... (More)
Simian virus 40 (SV40), a polyoma virus of the rhesus macaque was discovered in 1960 as a contaminant of human polio vaccines produced in monkey cells. A number of studies have reported the detection of SV40 nucleotide sequences in human tumors, mainly mesotheliomas, but the reports have not been consistent. The presence of SV40 in 26 consecutive cases of malignant mesothelioma of biphasic type was investigated using a SV40 quantitative real time polymerase chain reaction (PCR) with a sensitivity of 10 copies of viral DNA per sample. All the samples were also tested for amplifiability using a real-time PCR for the beta-globin gene. Eighteen tumors were amplifiable, but none contained SV40 DNA. The results do not support an association between mesothelioma and SV40. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Anticancer Research
volume
27
issue
6B
pages
4159 - 4161
publisher
International Institute of Cancer Research
external identifiers
  • pmid:18225586
  • wos:000251901700056
  • scopus:37549014837
ISSN
1791-7530
language
English
LU publication?
yes
id
0d78a721-50a6-4746-bf34-1f749f3c93cc (old id 1021018)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18225586?dopt=Abstract
date added to LUP
2008-02-13 15:28:13
date last changed
2017-10-22 04:51:40
@article{0d78a721-50a6-4746-bf34-1f749f3c93cc,
  abstract     = {Simian virus 40 (SV40), a polyoma virus of the rhesus macaque was discovered in 1960 as a contaminant of human polio vaccines produced in monkey cells. A number of studies have reported the detection of SV40 nucleotide sequences in human tumors, mainly mesotheliomas, but the reports have not been consistent. The presence of SV40 in 26 consecutive cases of malignant mesothelioma of biphasic type was investigated using a SV40 quantitative real time polymerase chain reaction (PCR) with a sensitivity of 10 copies of viral DNA per sample. All the samples were also tested for amplifiability using a real-time PCR for the beta-globin gene. Eighteen tumors were amplifiable, but none contained SV40 DNA. The results do not support an association between mesothelioma and SV40.},
  author       = {Lundstig, Annika and Dejmek, Annika and Eklund, Carina and Filinic, Ivo and Dillner, Joakim},
  issn         = {1791-7530},
  language     = {eng},
  number       = {6B},
  pages        = {4159--4161},
  publisher    = {International Institute of Cancer Research},
  series       = {Anticancer Research},
  title        = {No detection of SV40 DNA in mesothelioma tissues from a high incidence area in Sweden.},
  volume       = {27},
  year         = {2007},
}