No detection of SV40 DNA in mesothelioma tissues from a high incidence area in Sweden.
(2007) In Anticancer research 27(6B). p.4159-4161- Abstract
- Simian virus 40 (SV40), a polyoma virus of the rhesus macaque was discovered in 1960 as a contaminant of human polio vaccines produced in monkey cells. A number of studies have reported the detection of SV40 nucleotide sequences in human tumors, mainly mesotheliomas, but the reports have not been consistent. The presence of SV40 in 26 consecutive cases of malignant mesothelioma of biphasic type was investigated using a SV40 quantitative real time polymerase chain reaction (PCR) with a sensitivity of 10 copies of viral DNA per sample. All the samples were also tested for amplifiability using a real-time PCR for the beta-globin gene. Eighteen tumors were amplifiable, but none contained SV40 DNA. The results do not support an association... (More)
- Simian virus 40 (SV40), a polyoma virus of the rhesus macaque was discovered in 1960 as a contaminant of human polio vaccines produced in monkey cells. A number of studies have reported the detection of SV40 nucleotide sequences in human tumors, mainly mesotheliomas, but the reports have not been consistent. The presence of SV40 in 26 consecutive cases of malignant mesothelioma of biphasic type was investigated using a SV40 quantitative real time polymerase chain reaction (PCR) with a sensitivity of 10 copies of viral DNA per sample. All the samples were also tested for amplifiability using a real-time PCR for the beta-globin gene. Eighteen tumors were amplifiable, but none contained SV40 DNA. The results do not support an association between mesothelioma and SV40. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1021018
- author
- Lundstig, Annika LU ; Dejmek, Annika LU ; Eklund, Carina LU ; Filinic, Ivo and Dillner, Joakim LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Anticancer research
- volume
- 27
- issue
- 6B
- pages
- 4159 - 4161
- publisher
- International Institute of Cancer Research
- external identifiers
-
- pmid:18225586
- wos:000251901700056
- scopus:37549014837
- ISSN
- 1791-7530
- language
- English
- LU publication?
- yes
- id
- 0d78a721-50a6-4746-bf34-1f749f3c93cc (old id 1021018)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18225586?dopt=Abstract
- date added to LUP
- 2016-04-04 07:19:00
- date last changed
- 2022-03-15 06:47:32
@article{0d78a721-50a6-4746-bf34-1f749f3c93cc,
abstract = {{Simian virus 40 (SV40), a polyoma virus of the rhesus macaque was discovered in 1960 as a contaminant of human polio vaccines produced in monkey cells. A number of studies have reported the detection of SV40 nucleotide sequences in human tumors, mainly mesotheliomas, but the reports have not been consistent. The presence of SV40 in 26 consecutive cases of malignant mesothelioma of biphasic type was investigated using a SV40 quantitative real time polymerase chain reaction (PCR) with a sensitivity of 10 copies of viral DNA per sample. All the samples were also tested for amplifiability using a real-time PCR for the beta-globin gene. Eighteen tumors were amplifiable, but none contained SV40 DNA. The results do not support an association between mesothelioma and SV40.}},
author = {{Lundstig, Annika and Dejmek, Annika and Eklund, Carina and Filinic, Ivo and Dillner, Joakim}},
issn = {{1791-7530}},
language = {{eng}},
number = {{6B}},
pages = {{4159--4161}},
publisher = {{International Institute of Cancer Research}},
series = {{Anticancer research}},
title = {{No detection of SV40 DNA in mesothelioma tissues from a high incidence area in Sweden.}},
url = {{http://www.ncbi.nlm.nih.gov/pubmed/18225586?dopt=Abstract}},
volume = {{27}},
year = {{2007}},
}