Advanced

Fluorescence investigations to classify malignant laryngeal lesions in vivo.

Rydell, Roland LU ; Eker, Charlotta; Andersson-Engels, Stefan LU ; Krogdahl, Annelise; Wahlberg, Peter LU and Svanberg, Katarina LU (2008) In Head and Neck 30(4). p.419-426
Abstract
BACKGROUND:: The extent of surgical resection for malignant laryngeal lesions influences voice quality. An instrument to estimate histopathologic grading of dysplasia in vivo may spare normal tissue without increasing the risk of local failure. METHODS: Laryngeal lesions (N = 39; 21 after administration of delta-aminolevulinic acid (ALA)) were investigated with laser-induced fluorescence, and the results correlated to histopathologic grading in 4 groups: non/mild dysplasia (I), moderate dysplasia (II), severe dysplasia/cancer in situ (III), and carcinoma. RESULTS: At 337-nm excitation, there were differences in the fluorescence ratio I(431)/I(390) between groups I/III and carcinoma. Following 405-nm excitation, I(500 nm) group I differed... (More)
BACKGROUND:: The extent of surgical resection for malignant laryngeal lesions influences voice quality. An instrument to estimate histopathologic grading of dysplasia in vivo may spare normal tissue without increasing the risk of local failure. METHODS: Laryngeal lesions (N = 39; 21 after administration of delta-aminolevulinic acid (ALA)) were investigated with laser-induced fluorescence, and the results correlated to histopathologic grading in 4 groups: non/mild dysplasia (I), moderate dysplasia (II), severe dysplasia/cancer in situ (III), and carcinoma. RESULTS: At 337-nm excitation, there were differences in the fluorescence ratio I(431)/I(390) between groups I/III and carcinoma. Following 405-nm excitation, I(500 nm) group I differed significantly from group III and cancer. The sensitivity for the fluorescence method was 89%, and the specificity was 100%. CONCLUSIONS: There are differences in the in vivo tissue fluorescence between tissue with different gradings of dysplasia and carcinoma. (c) 2007 Wiley Periodicals, Inc. Head Neck, 2008. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Head and Neck
volume
30
issue
4
pages
419 - 426
publisher
John Wiley & Sons
external identifiers
  • pmid:18172880
  • wos:000254689800001
  • scopus:42549151422
ISSN
1043-3074
DOI
10.1002/hed.20719
language
English
LU publication?
yes
id
d8e4078e-fe07-48d8-999a-a8fd14e7428d (old id 1021640)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18172880?dopt=Abstract
date added to LUP
2008-02-13 15:12:22
date last changed
2017-01-01 05:17:21
@article{d8e4078e-fe07-48d8-999a-a8fd14e7428d,
  abstract     = {BACKGROUND:: The extent of surgical resection for malignant laryngeal lesions influences voice quality. An instrument to estimate histopathologic grading of dysplasia in vivo may spare normal tissue without increasing the risk of local failure. METHODS: Laryngeal lesions (N = 39; 21 after administration of delta-aminolevulinic acid (ALA)) were investigated with laser-induced fluorescence, and the results correlated to histopathologic grading in 4 groups: non/mild dysplasia (I), moderate dysplasia (II), severe dysplasia/cancer in situ (III), and carcinoma. RESULTS: At 337-nm excitation, there were differences in the fluorescence ratio I(431)/I(390) between groups I/III and carcinoma. Following 405-nm excitation, I(500 nm) group I differed significantly from group III and cancer. The sensitivity for the fluorescence method was 89%, and the specificity was 100%. CONCLUSIONS: There are differences in the in vivo tissue fluorescence between tissue with different gradings of dysplasia and carcinoma. (c) 2007 Wiley Periodicals, Inc. Head Neck, 2008.},
  author       = {Rydell, Roland and Eker, Charlotta and Andersson-Engels, Stefan and Krogdahl, Annelise and Wahlberg, Peter and Svanberg, Katarina},
  issn         = {1043-3074},
  language     = {eng},
  number       = {4},
  pages        = {419--426},
  publisher    = {John Wiley & Sons},
  series       = {Head and Neck},
  title        = {Fluorescence investigations to classify malignant laryngeal lesions in vivo.},
  url          = {http://dx.doi.org/10.1002/hed.20719},
  volume       = {30},
  year         = {2008},
}