Advanced

A microcalorimetric study of water vapor sorption on morphine sulphate

Markova, N and Wadsö, Lars LU (1999) In Journal of Thermal Analysis and Calorimetry 57(1). p.133-137
Abstract
Water vapor sorption on morphine sulphate was studied in a twin double sorption microcalorimeter at 25°C. The vapor sorption isotherm and the differential heats of sorption were determined simultaneously from dry condition to a water activity of 0.99. Two well resolved hydration steps were obtained on the sorption isotherm at water activities of 0.01 and 0.22 corresponding to the formation of dihydrate and pentahydrate of morphine sulphate. They were accompanied by constant values of the differential heats of sorption: –24 kJ mol–1(H2O) for the dihydrate formation and –10 kJ mol–1(H2O) for the pentahydrate formation.

The calorimetrically obtained sorption isotherms were compared with the results of Karl Fisher titrations of... (More)
Water vapor sorption on morphine sulphate was studied in a twin double sorption microcalorimeter at 25°C. The vapor sorption isotherm and the differential heats of sorption were determined simultaneously from dry condition to a water activity of 0.99. Two well resolved hydration steps were obtained on the sorption isotherm at water activities of 0.01 and 0.22 corresponding to the formation of dihydrate and pentahydrate of morphine sulphate. They were accompanied by constant values of the differential heats of sorption: –24 kJ mol–1(H2O) for the dihydrate formation and –10 kJ mol–1(H2O) for the pentahydrate formation.

The calorimetrically obtained sorption isotherms were compared with the results of Karl Fisher titrations of morphine sulphate samples equilibrated at different water activities. The appearance of a liquid phase in the morphine sulphate at high water activities is discussed on the basis of the obtained differential heats of sorption and measured heat capacities of morphine sulphate at different water activities. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Thermal Analysis and Calorimetry
volume
57
issue
1
pages
133 - 137
publisher
Akademiai Kiado
external identifiers
  • scopus:0032595515
ISSN
1588-2926
DOI
10.1023/A:1010166013177
language
English
LU publication?
yes
id
0a1a70bb-8e81-4078-81c5-03fa4716fdca (old id 1034495)
date added to LUP
2008-02-19 09:00:38
date last changed
2017-01-01 05:17:47
@article{0a1a70bb-8e81-4078-81c5-03fa4716fdca,
  abstract     = {Water vapor sorption on morphine sulphate was studied in a twin double sorption microcalorimeter at 25°C. The vapor sorption isotherm and the differential heats of sorption were determined simultaneously from dry condition to a water activity of 0.99. Two well resolved hydration steps were obtained on the sorption isotherm at water activities of 0.01 and 0.22 corresponding to the formation of dihydrate and pentahydrate of morphine sulphate. They were accompanied by constant values of the differential heats of sorption: –24 kJ mol–1(H2O) for the dihydrate formation and –10 kJ mol–1(H2O) for the pentahydrate formation.<br/><br>
The calorimetrically obtained sorption isotherms were compared with the results of Karl Fisher titrations of morphine sulphate samples equilibrated at different water activities. The appearance of a liquid phase in the morphine sulphate at high water activities is discussed on the basis of the obtained differential heats of sorption and measured heat capacities of morphine sulphate at different water activities.},
  author       = {Markova, N and Wadsö, Lars},
  issn         = {1588-2926},
  language     = {eng},
  number       = {1},
  pages        = {133--137},
  publisher    = {Akademiai Kiado},
  series       = {Journal of Thermal Analysis and Calorimetry},
  title        = {A microcalorimetric study of water vapor sorption on morphine sulphate},
  url          = {http://dx.doi.org/10.1023/A:1010166013177},
  volume       = {57},
  year         = {1999},
}